Results 41 to 50 of about 290,324 (267)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A study of the psychological mechanisms of job burnout: implications of person–job fit and person–organization fit

Frontiers in Psychology
Job burnout and work pressure are pivotal concerns in human resource management and workplace mental health, profoundly impacting organizational sustainability and individual well-being. Grounded in the person–environment fit theory, this empirical study
Panpan Zeng, Panpan Zeng, Xiaoli Hu
doaj   +1 more source

ملاءمة الفرد-بيئة العمل: المفهوم، الأهميّة، المستويات، والآثار.. دراسة وصفية [PDF]

المجلة العربية للإدارة
تتمركز دراسات ملاءمة الفرد-بيئة العمل حول ضرورة بناء واستدامة الملاءمة الجيدة بين الأفراد وهذه البيئة. ومع أنّ هذا المجال الحديث من الدراسات يعدُّ مجالاً مركزيّاً في الأدبيات الغربيّة، إلا أنّه ما زالت الأدبيات العربيّة تعاني من نقصٍ واضحٍ تنظيرا ...
عبدالله مداري الحربي
doaj   +1 more source

PRO-Fit: A personalized fitness assistant framework

International Conferences on Software Engineering and Knowledge Engineering, 2016
The advancements in wearable technology, where embedded accelerometers, gyroscopes and other sensors enable the users to actively monitor their activity have made it easier for individuals to pursue a healthy lifestyle. However, most of the existing applications expect continuous feedback from the end users and fail to engage those who have busy ...
Saumil Dharia, Vijesh Jain, Jvalant Patel, Jainikkumar Vora, Shaurya Chawla, Magdalini Eirinaki   +5 more
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Use of Full Hierarchy Consistency Index to Assess Response Consistency

International Journal of Assessment Tools in Education, 2018
Measurement models need to properly delineatethe real aspect of examinees’ response processes for measurement accuracypurposes. To avoid invalid inferences, fit of examinees’ response data to themodel is studied through person-fitstatistics.
Lokman Akbay, Mustafa Kılınç
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Relationship between Perceived Fit of Nurses and Organizational Citizenship Behavior in Shiraz Hospitals

Journal of Research Development in Nursing and Midwifery, 2014
Background and Objective: This study aimed to investigate the relationship between perceived fit of nurses and organizational citizenship behavior. Material and Methods: The statistical population of this correlational study was all nurses of Shiraz ...
Abdozahra Naami, Farideh Ensafdaran, Nasir Dastan, Mohammad Babamiri   +3 more
doaj