Results 111 to 120 of about 30,268 (263)
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Person-centred psychometrics and cognitive style: moving from variables to a person-centred approach
, 2016 Cognitive style refers to the way in which we prefer to think and process information. Within the framework of individual differences, cognitive style has much to offer with regards to our understanding of how people think.
Costello, Shane +1 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Development of a multidimensional instrument of person-environment fit: The Perceived Person-Environment Fit Scale (PPEFS) [PDF]
, 2016 This research identifies four challenges in the field of person–environment fit (PE fit): the multidimensionality of PE fit, the integration of fit theories, the simultaneous effects of the multiple dimensions, and the function of the dimensions.
Chuang, Aichia +1 more
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
, 2015 경쟁이 더욱 치열해진 오늘날의 경영환경 속에서 조직의 경쟁력 확보를 위하여 조직의 핵심자원으로 인식되고 있는 우수한 인적자원의 확보와 유지 및 관리가 기업성패의 중요한 요인 중 하나로 대두되었다. 오늘날의 인적자원의 특성은 무조건 일에 매진하기 보다는 일과 삶의 균형을 추구하고, 일을 통해 자아성취나 개인적 가치들을 추구하고자 하는 경향을 띠고 있다.
송민영
core
Asia Pacific Journal of Health ManagementThe interplay between professional commitments and personal life has become an important point to ponder over, particularly within the diverse socio-economic landscape of Pan-Asian countries.
Ilavarasan Rajendran +4 more
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source