Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors [PDF]
STAR Protocols, 2022 Summary: Hydrogen sulfide (H2S) and downstream reactive sulfur species (RSS), including organic persulfides, protect bacterial cells against diverse oxidative stressors.
Joseph N. Fakhoury +2 more
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Possible molecular basis of the biochemical effects of cysteine-derived persulfides [PDF]
Frontiers in Molecular Biosciences, 2022 Persulfides (RSSH/RSS−) are species closely related to thiols (RSH/RS−) and hydrogen sulfide (H2S/HS−), and can be formed in biological systems in both low and high molecular weight cysteine-containing compounds.
Ernesto Cuevasanta +15 more
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How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology [PDF]
Redox Biology, 2023 In an attempt to understand the cellular mechanisms of H2S signalling, recent research has focused on supersulfide (i.e., alkyl and inorganic hydropersulfide) formation and subsequent reactivity.
Christopher H. Switzer
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Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism [PDF]
Antioxidants, 2023 Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals.
Qamarul Hafiz Zainol Abidin +13 more
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Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors [PDF]
Frontiers in PhysiologyReactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi +6 more
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N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells [PDF]
Cells, 2019 Hydrogen sulfide (H2S) is an endogenously produced signaling molecule. The enzymes 3-mercaptopyruvate sulfurtransferase (MST), partly localized in mitochondria, and the inner mitochondrial membrane-associated sulfide:quinone oxidoreductase (SQR), besides
Karim Zuhra +8 more
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Reactive Sulfur Species and Protein Persulfidation: An Emerging Redox Axis in Human Health and Disease [PDF]
Current Issues in Molecular BiologyReactive sulfur species (RSS)—hydrogen sulfide (H2S), low-molecular-weight persulfides/polysulfides and protein persulfidation—constitute a third redox axis alongside ROS and RNS.
Celia María Curieses Andrés +5 more
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Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples [PDF]
Nature CommunicationsH2S reversibly modifies low molecular weight (LMWSH) and protein (PrSH) thiols to form persulfides (RSS−) and polysulfides (RS(S)nS−) for antioxidant defence and regulation of activity.
Jan Lj. Miljkovic +12 more
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Cysteine-based redox regulation and signalling in plants [PDF]
Frontiers in Plant Science, 2013 Living organisms are subjected to oxidative stress conditions which are characterized by the production of reactive oxygen (ROS), nitrogen (RNS) and sulfur (RSS) species.
Jérémy eCouturier +3 more
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Dual Roles of Reducing Systems in Protein Persulfidation and Depersulfidation [PDF]
AntioxidantsThe oxidative modification of specific cysteine residues to persulfides is thought to be the main way by which hydrogen sulfide (H2S) exerts its biological and signaling functions. Therefore, protein persulfidation represents an important thiol-switching
Zhichao Liu +2 more
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