Results 11 to 20 of about 1,976 (189)

Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity [PDF]

Redox Biology
Unfolded protein response (UPR) is activated in cells under endoplasmic reticulum (ER) stress. One sensor protein involved in this response is PERK, which is activated through its redox-dependent oligomerization.
Shin Koike, Hideo Kimura, Yuki Ogasawara
doaj   +2 more sources

Acidity and nucleophilic reactivity of glutathione persulfide [PDF]

Journal of Biological Chemistry, 2020
Persulfides (RSSH/RSS2) participate in sulfur trafficking and metabolic processes, and are proposed to mediate the signaling effects of hydrogen sulfide (H2S). Despite their growing relevance, their chemical properties are poorly understood.
Alvarez, Beatriz, Benchoam, Dayana, Cuevasanta, Ernesto, Estrin, Dario Ariel, Ferrer-Sueta, Gerardo, Grassano, Juan S., Mastrogiovanni, Mauricio, Möller, Matías N., Semelak, Jonathan Alexis, Trujillo, Madia, Zeida Camacho, Ari Fernando   +10 more
core   +7 more sources

Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress [PDF]

Redox Biology
Acute inflammatory responses often involve the production of reactive oxygen and nitrogen species by innate immune cells, particularly macrophages. How activated macrophages protect themselves in the face of oxidative-inflammatory stress remains a long ...
Talal Salti, Ilana Braunstein, Yael Haimovich, Tamar Ziv, Moran Benhar   +4 more
doaj   +2 more sources

Reaction of peroxynitrite with thiols, hydrogen sulfide and persulfides [PDF]

Redox Biochemistry and Chemistry
Three decades of research on the biochemistry of peroxynitrite (ONOOH/ONOO−) have established that this stealthy oxidant is formed in biological systems, and that its main targets are carbon dioxide (CO2), metalloproteins and thiols (RSH).
Madia Trujillo, Ernesto Cuevasanta, Lucía Turell, Dayana Benchoam, Gerardo Ferrer-Sueta, Ari Zeida, Celia Quijano, Sebastián Carballal, Rafael Radi, Beatriz Alvarez   +9 more
doaj   +3 more sources

New role for thioredoxins in plants: Implication of TRXo1 in protein depersulfidation [PDF]

Redox Biology
Persulfidation, a posttranslational modification of cysteines to persulfides, is the best characterized molecular mechanism of H2S signaling. This study is focused on new functions for thioredoxins (TRXs) in plants beyond those of thiol disulfide (S–S ...
Sabrina De Brasi-Velasco, Angeles Aroca, Luis C. Romero, Cecilia Gotor, Francisca Sevilla, Ana Jiménez   +5 more
doaj   +2 more sources

Synthetic Motifs for Understanding Lewis Acid Interactions with Persulfides and Thioselenides. [PDF]

Angew Chem Int Ed Engl
Using isolated dichalcogenides as precursors, we report the synthesis, characterization, and reactivity of Zn persulfide and thioselenide complexes. 77Se NMR shows distinct impacts to electronic structure and reactivity between different thioselenides coordinated to different Lewis acids.
Li K, Sattler AJ, Zakharov LN, Pluth MD.
europepmc   +3 more sources

Cation Vacancies Enable Anion Redox in Li Cathodes. [PDF]

J Am Chem Soc
Conventional Li-ion battery intercalation cathodes leverage charge compensation that is formally associated with redox on the transition metal. Employing the anions in the charge compensation mechanism, so-called anion redox, can yield higher capacities ...
Kim SS, Kitchaev DA, Patheria ES, Morrell CT, Qian MD, Andrews JL, Yan Q, Ko ST, Luo J, Melot BC, Van der Ven A, See KA.   +11 more
europepmc   +3 more sources

Emerging Chemical Biology of Protein Persulfidation. [PDF]

Antioxid Redox Signal, 2023
Significance: Protein persulfidation (the formation of RSSH), an evolutionarily conserved oxidative posttranslational modification in which thiol groups in cysteine residues are converted into persulfides, has emerged as one of the main mechanisms through which hydrogen sulfide (H2S) conveys its signaling.
Vignane T, Filipovic MR.
europepmc   +3 more sources

Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Angewandte Chemie, 2022
AbstractProtein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur bond for subsequent detection by mass spectrometry.
Danny Schilling, Uladzimir Barayeu, Raphael R. Steimbach, Deepti Talwar, Aubry K. Miller, Tobias P. Dick   +5 more
openaire   +2 more sources

Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics

Frontiers in Microbiology, 2023
A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack.
Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Yosuke Maeda, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike, Tomohiro Sawa   +17 more
doaj   +1 more source