Results 51 to 60 of about 1,976 (189)

Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress [PDF]

, 2022
journal ...
Akaike Takaaki, Akiyama Masahiro, Anzai Naohiko, Aoki Hanako, Furumoto Yuka, Kumagai Yoshito, Nishida Motohiro, Nishimura Akiyuki, Nishiyama Kazuhiro, Shinkai Yasuhiro, Unoki Takamitsu, Warabi Eiji   +11 more
core   +1 more source

Thiosulfonate‐Derived BODIPY “Stick and Glue” Strategy for Fluorescent Thiol Labeling

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
We present a powerful photochemical strategy for converting disulfide bonds into stable thioether linkages via a [1,2]‐sigmatropic rearrangement. By integrating this reaction into traditional methanethiosulfonate‐based thiol labeling, we enable light‐triggered stabilization of peptide and protein conjugates with enhanced robustness and versatility ...
Lucie Šálková, David Dunlop, B. Buse Tütüncü, Zdeněk Knejzlík, Tomáš Slanina   +4 more
wiley   +2 more sources

The reactive species interactome: evolutionary emergence, biological significance, and opportunities for redox metabolomics and personalized medicine [PDF]

, 2017
SIGNIFICANCE: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not administration of antioxidants is ineffective, suggesting our current understanding of the underlying ...
Alan A. Jackson, Andreas Pasch, Anne Koning, Borsook H, Christopher L. Bianco, David A. Wink, Dhanakoti SN, Gunter G.C. Kuhnle, Harry van Goor, Holmes FL, Horowitz JH, Jon M. Fukuto, Kenneth R. Olson, Martin Feelisch, Miriam M. Cortese-Krott, Moncada S, Peter Nagy, Pizzarello S, Sherman H, Storch KJ, Ueland PM, Wakabayashi Y, Windmueller HG, Windmueller HG, Wootton S, Wächtershäuser G   +25 more
core   +2 more sources

3-Mercaptopyruvate sulfur transferase is a protein persulfidase [PDF]

, 2023
Protein S-persulfidation (P-SSH) is recognized as a common posttranslational modification. It occurs under basal conditions and is often observed to be elevated under stress conditions. However, the mechanism(s) by which proteins are persulfidated inside
Barayeu, Uladzimir, Dick, Tobias P., Glatt, Sebastian, Luzarowski, Marcin, Pedre, Brandán, Schilling, Danny, Sokołowski, Mikołaj, Talwar, Deepti   +7 more
core   +3 more sources

Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

Antioxidants, 2022
Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous
Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose   +11 more
doaj   +1 more source

Thioredoxin Profiling of Multiple Thioredoxin-Like Proteins in Staphylococcus aureus

Frontiers in Microbiology, 2018
Hydrogen sulfide (H2S) is thought to signal through protein S-sulfuration (persulfidation; S-sulfhydration) in both mammalian systems and bacteria. We previously profiled proteome S-sulfuration in Staphylococcus aureus (S.
Hui Peng, Hui Peng, Yixiang Zhang, Yixiang Zhang, Jonathan C. Trinidad, Jonathan C. Trinidad, David P. Giedroc, David P. Giedroc   +7 more
doaj   +1 more source

Nitrosylation of nitric-oxide-sensing regulatory proteins containing [4Fe-4S] clusters gives rise to multiple iron-nitrosyl complexes [PDF]

, 2016
The reaction of protein-bound iron–sulfur (Fe-S) clusters with nitric oxide (NO) plays key roles in NO-mediated toxicity and signaling. Elucidation of the mechanism of the reaction of NO with DNA regulatory proteins that contain Fe-S clusters has been ...
Alp, Ercan E., Crack, Jason C., Cramer, Stephen P., Hu, Michael Y., Hutchings, Matthew I., Kamali, Saeed, Le Brun, Nick E., Oganesyan, Vasily S., Prior, Christopher, Serrano, Pauline N., Thomson, Andrew J., Wang, Hongxin, Yoda, Yoshitaka, Zhao, Jiyong   +13 more
core   +2 more sources

Using resonance synchronous spectroscopy to characterize the reactivity and electrophilicity of biologically relevant sulfane sulfur

Redox Biology, 2019
Sulfane sulfur is common inside cells, playing both regulatory and antioxidant roles. However, there are unresolved issues about its chemistry and biochemistry.
Huanjie Li, Huaiwei Liu, Zhigang Chen, Rui Zhao, Qingda Wang, Mingxue Ran, Yongzhen Xia, Xin Hu, Jihua Liu, Ming Xian, Luying Xun   +10 more
doaj   +1 more source

NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function [PDF]

, 2015
The Rrf2 family transcription factor NsrR controls expression of genes in a wide range of bacteria in response to nitric oxide (NO). The precise form of the NO-sensing module of NsrR is the subject of controversy because NsrR proteins containing either ...
Al-Bassam, Mahmoud, Crack, Jason, Cramer, Stephen, Dodd, Erin, Hamilton, Christopher, Holland, Ashley, Hutchings, Matthew, Johnson, Michael, Kamali, Saeed, Knowles, Felicity, Le Brun, Nick, Munnoch, John Tyson, Thomson, Andrew   +12 more
core   +1 more source

Biochemical properties of Paracoccus denitrificans FnrP:Reactions with molecular oxygen and nitric oxide [PDF]

, 2016
In Paracoccus denitrificans, three CRP/FNR family regulatory proteins, NarR, NnrR and FnrP, control the switch between aerobic and anaerobic (denitrification) respiration.
A Volbeda, A Yan, AJ Jervis, Andrew J. Thomson, AS Fleischhacker, B Weiss, B Zhang, CP Tseng, CT Przysiecki, CV Popescu, D Ralt, DJ Richardson, DJ Shaw, DM Bates, F Sievers, G Sawers, H Beinert, H Reents, J Crack, J Edwards, J Green, Jason C. Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Crack, JC Drapier, L Bergaust, LJ Moore, LR Bakken, M Matsui, Matthew I. Hutchings, MC Broillet, MF Otten, MI Hutchings, MI Hutchings, MM Bradford, N Filenko, Nick E. Le Brun, NJ Watmough, P Bouchal, PJ Kiley, R Bruckdorfer, R Veldman, RJ Spanning Van, RJ Spanning van, SA Ibrahim, SB Melville, ST Pullan, VR Sutton, WG Zumft, YM Kwon, YY Lee   +57 more
core   +1 more source