Results 31 to 40 of about 73,738 (335)
Identification of highly selective covalent inhibitors by phage display
Nature Biotechnology, 2020 Molecules that covalently bind macromolecular targets have found widespread applications as activity-based probes and as irreversibly binding drugs. However, the general reactivity of the electrophiles needed for covalent bond formation makes control of ...
Shiyu Chen +5 more
semanticscholar +1 more source
Fv antibodies to aflatoxin B1 derived from a pre-immunized antibody phage display library system [PDF]
, 2002 The production and characterization of recombinant antibodies to aflatoxin B[SUB1] (AFB[SUB1]), a potent mycotoxin and carcinogen is described. The antibody fragments produced were then applied for use in a surface plasmon resonance-based biosensor ...
Daly, Stephen J. +6 more
core +1 more source
Microbiology Spectrum, 2015 ABSTRACT Despite the availability of antimicrobial drugs, the continued development of microbial resistance—established through escape mutations and the emergence of resistant strains—limits their clinical utility. The discovery of novel, therapeutic, monoclonal antibodies (mAbs) offers viable clinical alternatives in the ...
Jared, Sheehan, Wayne A, Marasco
openaire +2 more sources
Identification of Calpain Substrates by ORF Phage Display
Molecules, 2011 Substrate identification is the key to defining molecular pathways or cellular processes regulated by proteases. Although phage display with random peptide libraries has been used to analyze substrate specificity of proteases, it is difficult to deduce ...
Wei Li +2 more
doaj +1 more source
Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA) [PDF]
, 2013 The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage
Shen, Duanwen +15 more
core +1 more source
Molecules, 2021 Mycotoxins, the small size secondary metabolites of fungi, have posed a threat to the safety of medicine, food and public health. Therefore, it is essential to create sensitive and effective determination of mycotoxins.
Wei Sun, Yan Zhang, Zhigang Ju
doaj +1 more source
Frameshifting in the P6 cDNA Phage Display System
Molecules, 2010 Phage display is a powerful technique that enables easy identification of targets for any type of ligand. Targets are displayed at the phage surface as a fusion protein to one of the phage coat proteins.
Veerle Somers +3 more
doaj +1 more source
Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and Therapy
Molecules, 2011 Twenty years after its development, antibody phage display using filamentous bacteriophage represents the most successful in vitro antibody selection technology.
Michael Hust +4 more
doaj +1 more source
bioRxiv, 2020 In vivo phage display is widely used for identification of organ- or disease-specific homing peptides. However, the current in vivo phage biopanning approaches fail to assess biodistribution of specific peptide phages across tissues during the screen ...
K. Pleiko +5 more
semanticscholar +1 more source
Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies
Вавиловский журнал генетики и селекции, 2021 Combinatorial biology methods offer a good solution for targeting interactions of specific molecules by a high-throughput screening and are widely used for drug development, diagnostics, identification of novel monoclonal antibodies, search for linear ...
A. N. Chikaev +3 more
doaj +1 more source