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Overcoming Bacteriophage Resistance in Phage Therapy
2023Antibiotic resistance among pathogenic bacteria is one of the most severe global challenges. It is predicted that over ten million lives will be lost annually by 2050. Phage therapy is a promising alternative to antibiotics. However, the ease of development of phage resistance during therapy is a concern.
Laanto Elina, Laanto Elina
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Interference resistant mutants of phage f1
Virology, 1982Abstract We have isolated and characterized a type of viable mutant (IR) of bacteriophage f1 that is resistant to interference by DI particles. Two mutations in a gene (II) that controls phage replication are required for the full IR phenotype. One of these mutations by itself confers a semi-IR character; the other amplifies its phenotype but is ...
V, Enea, N D, Zinder
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Journal of Virology
Phage therapy is a promising approach to treat infections caused by drug-resistant Stenotrophomonas maltophilia (S. maltophilia) . However, the rapid development of phage resistance has hindered the therapeutic application of phages. In vitro evolutionary studies of bacteria–phage co-cultures
Pengjun Han +3 more
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Phage therapy is a promising approach to treat infections caused by drug-resistant Stenotrophomonas maltophilia (S. maltophilia) . However, the rapid development of phage resistance has hindered the therapeutic application of phages. In vitro evolutionary studies of bacteria–phage co-cultures
Pengjun Han +3 more
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Phage resistance in lactic acid bacteria
Biochimie, 1988The interactions between lactic acid bacteria and their phages are commercially significant. Current research has focused on the elucidation of the mechanisms and genetics of phage resistance. Phage resistance genes have been linked to plasmid DNA for Streptococcus lactis and Streptococcus cremoris, and preliminary studies suggest the operation of ...
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Transformation of phage-resistance inBacillus subtilis
Experientia, 1969Mit Hilfe von extrahierter DNS wurde der genetische «Marker» der Phagenresistenz auf phagensensible Bakterien ubertragen.
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Studies on a smooth phage resistant variant of Brucella abortus II. Mechanism of phage resistance.
British journal of experimental pathology, 1976The properties of a smooth phage resistant variant of Brucella abortus were studied in an attempt to determine the mechanism of phage resistance. This strain was fully capable of adsorbing phage but penetration, and hence replication, did not occur.
M J, Corbel, J A, Morris
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Antibiotic Resistance in the Patient With Cancer: Escalating Challenges and Paths Forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, David E Greenberg
exaly
Investigation of a phage resistant
MGG Molecular & General Genetics, 1996Steve Grkovic, H. K. Mahanty
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Phage resistance in Haemophilus influenzae
Biochemical and Biophysical Research Communications, 1968openaire +2 more sources