Results 1 to 10 of about 50,676 (143)
Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]
mBio, 2019 Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Melissa Cruz-Acuña +2 more
doaj +4 more sources
Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells [PDF]
Frontiers in Immunology, 2017 Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity.
Federico Battisti +16 more
doaj +4 more sources
A Bumpy Ride of Mycobacterial Phagosome Maturation: Roleplay of Coronin1 Through Cofilin1 and cAMP
Frontiers in Immunology, 2021 Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils marshal an essential role in eliminating intracellular microorganisms.
Saradindu Saha +5 more
doaj +1 more source
Biology, 2021 Lyme disease is the most common vector-borne illness in North America and Europe. Its causative agents are spirochetes of the Borrelia burgdorferi sensu latu complex.
Philipp Woitzik, Stefan Linder
doaj +1 more source
The SecA2 pathway of Mycobacterium tuberculosis exports effectors that work in concert to arrest phagosome and autophagosome maturation. [PDF]
PLoS Pathogens, 2018 To subvert host defenses, Mycobacterium tuberculosis (Mtb) avoids being delivered to degradative phagolysosomes in macrophages by arresting the normal host process of phagosome maturation.
Katelyn E Zulauf +2 more
doaj +1 more source
Better Together: Current Insights Into Phagosome-Lysosome Fusion
Frontiers in Immunology, 2021 Following phagocytosis, the nascent phagosome undergoes maturation to become a phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill and digest engulfed microbes, cells, and debris.
Jenny A. Nguyen +3 more
doaj +1 more source
Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages [PDF]
, 2008 This study provides the proof of principle that probing the host and the microbe transcriptomes simultaneously is a valuable means to accessing unique information on host pathogen interactions.
A Kolb-Maurer +86 more
core +15 more sources
Frontiers in Cellular and Infection Microbiology, 2023 Tuberculosis (TB) is an infectious disease caused by the bacteria of the Mycobaterium tuberculosis (Mtb) complex. The modulation of the lipid metabolism has been implicated in the immune response regulation, including the formation of lipid droplets (LD ...
Patrícia Elaine de Almeida +5 more
doaj +1 more source
eLife, 2022 Autophagosomes are double-membrane intracellular vesicles that degrade protein aggregates, intracellular organelles, and other cellular components.
Omar Peña-Ramos +6 more
doaj +1 more source
Scientific Reports, 2020 Effective phagocytosis is crucial for host defense against pathogens. Macrophages entrap pathogens into a phagosome and subsequently acidic lysosomes fuse to the phagosome.
Hiroyuki Tabata +4 more
doaj +1 more source