Results 11 to 20 of about 50,774 (237)

Phagosomal transport depends strongly on phagosome size [PDF]

Scientific Reports, 2017
AbstractMacrophages internalize pathogens for intracellular degradation. An important part of this process is the phagosomal transport from the cell periphery to the perinuclear region. Biochemical factors are known to influence the fate of phagosomes. Here, we show that the size of phagosomes also has a strong influence on their transport.
Keller, S., Berghoff, K., Kress, H.
openaire   +4 more sources

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction [PDF]

, 2015
Date of Acceptance: 02/02/2015 Copyright © 2015, American Society for Microbiology.
Bain, Judith M, Erwig, Lars-Peter, Gow, Neil A R, Lyall, Natalie, Okai, Blessing   +4 more
core   +6 more sources

The phagosome proteome: insight into phagosome functions. [PDF]

The Journal of cell biology, 2001
Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins.
J, Garin, R, Diez, S, Kieffer, J F, Dermine, S, Duclos, E, Gagnon, R, Sadoul, C, Rondeau, M, Desjardins   +8 more
openaire   +2 more sources

TRPC6 channel translocation into phagosomal membrane augments phagosomal function [PDF]

Proceedings of the National Academy of Sciences, 2015
SignificanceHistorically, pulmonary infections treated with antibiotics killed bacteria while selecting for the unintended development of pathogenic resistance. One strategy to circumvent antibiotic resistance in pulmonary infection involves targeting the host phagosome and augmenting its function.
Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.   +19 more
openaire   +3 more sources

Mycobacterium tuberculosis phagosome [PDF]

Molecular Microbiology, 1999
The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells.
Deretic, Vojo, Fratti, R. A.
openaire   +3 more sources

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [PDF]

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Aebischer, Toni, Blackburn, Clare, Brand, Janko, Brinkmann, Volker, Hoffmann, Kirstin, Lippuner, Christoph, Paape, Daniel, Paterou, Athina, Richardson, Melville, Smith, Andrew   +9 more
core   +1 more source

Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell [PDF]

, 2013
PubMed ID: 23592993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Castaneda-Garcia, A Di, A Kumar, AL Radtke, AM Cooper, BE Steinberg, BP Cormack, CE Barry 3rd, CM Sassetti, D Wagner, David G. Russell, DE Voth, DG Russell, DG Russell, H Barriere, H Ohno, HC Mwandumba, HD Park, J Rengarajan, JC Antoine, JL Flynn, K Pethe, K von Bargen, KH Rohde, LE Via, MI Voskuil, ND Sonawane, ND Sonawane, Neelima Sukumar, P Carroll, P Golby, PM Haggie, RB Abramovitch, RJ North, RM Yates, Robert B. Abramovitch, S Sturgill-Koszycki, S Sturgill-Koszycki, SB Walters, Shumin Tan, SM Payne, T Soldati, T Stauber, Tanya Parish, TB Reddy, UE Schaible, V Faundez, W Epstein, William R. Bishai   +48 more
core   +8 more sources

Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

Frontiers in Immunology, 2021
The membrane attack complex (MAC) of the complement system and Perforin-1 are well characterized innate immune effectors. MAC is composed of C9 and other complement proteins that target the envelope of gram-negative bacteria.
Leidy C. Merselis, Zachary P. Rivas, George P. Munson   +2 more
doaj   +1 more source

Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]

, 1996
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD, Gustavsson, M, Majeed, M, Sanan, DA, Stendahl, O, Zimmerli, S   +5 more
core   +2 more sources