Results 31 to 40 of about 50,774 (237)
The Capsule of
mSphere, 2018 Phagosomal acidification is a critical cellular mechanism for the inhibition and killing of ingested microbes by phagocytic cells. The acidic environment activates microbicidal proteins and creates an unfavorable environment for the growth of many ...
Carlos M. De Leon-Rodriguez +4 more
doaj +1 more source
Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response [PDF]
, 2018 Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms.
Hanson, Phyllis I +7 more
core +2 more sources
SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]
, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F +8 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Phagocytosis, a critical early event in the microbicidal response of neutrophils, is now appreciated to serve multiple functions in a variety of cell types. Professional phagocytes play a central role in innate immunity by eliminating pathogenic bacteria,
Justin J. Lim +4 more
doaj +1 more source
trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
eLife, 2022 The phagocytic receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Whether appropriate levels of CED-1 are maintained for executing the engulfment function remains unknown ...
Lei Yuan +4 more
doaj +1 more source
Analysis of phagosomal proteomes: From latex‐bead to bacterial phagosomes [PDF]
PROTEOMICS, 2010 Abstract Phagosomal proteome characterization has contributed significantly to the understanding of host–pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead‐containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast,
Qingbo, Li +4 more
openaire +2 more sources
Histoplasma Responses to Nutritional Immunity Imposed by Macrophage Activation
Journal of Fungi, 2019 The fungal pathogen Histoplasma capsulatum resides within the phagosome of host phagocytic cells. Within this intracellular compartment, Histoplasma yeast replication requires the acquisition of several essential nutrients, including metal ions.
Peter J. Brechting, Chad A. Rappleye
doaj +1 more source
Frontiers in Immunology, 2021 Phagocytosis is a receptor-mediated process used by cells to engulf a wide variety of particulates, including microorganisms and apoptotic cells. Many of the proteins involved in this highly orchestrated process are post-translationally modified with ...
Charneal L. Dixon +7 more
doaj +1 more source
Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis [PDF]
, 2017 Acknowledgements: The authors would like to acknowledge Fraser P. Coxon and Ian Ganley for providing LC3-GFP-mCherry BMDMs. M.S.G. was supported by an FEMS research grant and F.L.v.d.V.
Alonso, M Fernanda +8 more
core +2 more sources
Endosomal and Phagosomal SNAREs [PDF]
Physiological Reviews, 2018 The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport.
Ilse Dingjan +5 more
openaire +4 more sources