Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling. [PDF]
PLoS ONEProhibitin 1 (PHB1) and prohibitin 2 (PHB2) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. They are ubiquitously expressed and implicated in the regulation of cell proliferation, migration,
Mei Li +9 more
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PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway [PDF]
Open Life SciencesFibrosis is the primary cause of retinal detachment and visual decline. Here, we investigated the role of Prohibitin 2 (PHB2) in modulating fibrosis in ARPE-19 cells stimulated by transforming growth factor (TGF)-β2.
Chen Feng, Cai Xiaoxiao, Yu Ying
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Prohibitin 2 ameliorates cisplatin-induced acute kidney injury by modulating mitochondrial homeostasis [PDF]
Frontiers in PhysiologyAcute kidney injury (AKI), associated with a major health burden globally, is frequently caused by nephrotoxic agents, specifically cisplatin. Prohibitin (PHB) 2, a highly conserved mitochondrial protein localized at the inner mitochondrial membrane, is ...
Qi Zhang +4 more
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Role of PHB2 as a potential biomarker in pan-cancer: a multi-database analysis [PDF]
Scientific ReportsProhibitin2 (PHB2) is a mitochondrial endosomal protein that is closely linked to tumors; however, its specific molecular role remains unclear. Therefore, this study investigates the role of PHB2 in cancer.
Jingxin Zhang
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Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock. [PDF]
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
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PHB2 mitigates intervertebral disc degeneration by modulating mitophagy to inhibit necroptosis in nucleus pulposus cells [PDF]
iScienceSummary: Intervertebral disc degeneration involves loss of nucleus pulposus (NP) cells driven by inflammatory and mitochondrial stress-related death pathways.
Zhenyu Zhu +6 more
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PHB1 and PHB2 positively regulate IFN-β production by targeting MAVS in ducks [PDF]
Poultry SciencePHB1 and PHB2, two subunits of the mitochondrial prohibitin complex, are critical regulators of antiviral innate immunity. Ducks, as natural reservoirs for RNA viruses, exhibit unique antiviral mechanisms.
Jinlu Liu +5 more
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Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control [PDF]
Clinical and Translational MedicineBackground The induction of mitochondrial quality control (MQC) mechanisms is essential for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during periods of stress.
Jun Tao +5 more
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Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis [PDF]
Nature CommunicationsThe spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely
Tianyi Ding +10 more
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Krüppel like factor 7 regulates mitochondrial dynamics balance in myocardial infarction [PDF]
Communications BiologyTargeting the balance of mitochondrial fission and fusion can effectively alleviate the cardiac energy supply efficiency, to restore cardiac systolic dysfunction and reduce mortality.
Cao Wang +12 more
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