Results 91 to 100 of about 4,788 (163)

Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics

International Journal of Medical Sciences
This study aims to elucidate the roles of Phosphoglycerate Mutase Family Member 5 (Pgam5) and Prohibitin 2 (Phb2) in the context of hyperglycemia-induced myocardial dysfunction, a critical aspect of diabetic cardiomyopathy. The research employed primary cardiomyocytes, which were then subjected to hyperglycemia treatment to mimic diabetic conditions ...
Chen, Yingzhen, Huang, Jungang, Zhou, Hao, Lin, Jianguo, Tao, Jun   +4 more
openaire   +2 more sources

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects

Journal of Experimental & Clinical Cancer Research, 2019
Background Diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas accounting for approximately a third of non-Hodgkin lymphomas. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and ...
Hafidha Bentayeb, Marine Aitamer, Barbara Petit, Lydie Dubanet, Sabria Elderwish, Laurent Désaubry, Armand de Gramont, Eric Raymond, Agnès Olivrie, Julie Abraham, Marie-Odile Jauberteau, Danielle Troutaud   +11 more
doaj   +1 more source

Author Correction: Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy. [PDF]

Acta Pharmacol Sin
Wang L, Tang XQ, Shi Y, Li HM, Meng ZY, Chen H, Li XH, Chen YC, Liu H, Hong Y, Xu HH, Liu L, Zhao L, Han WN, Liu X, Zhang Y.   +15 more
europepmc   +2 more sources

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells

Journal of Dairy Science
: Mitochondrial dysfunction has been reported to occur in the mammary gland of dairy cows suffering from ketosis. Prohibitin 2 (PHB2) plays a crucial role in regulating mitophagy, which clears impaired mitochondria to maintain normal mitochondrial ...
Guojin Li, Liguang Cao, Kai Liu, Yifei Dong, Zifeng Yang, Jianchun Luo, Wenrui Gao, Lin Lei, Yuxiang Song, Xiliang Du, Xinwei Li, Wenwen Gao, Guowen Liu   +12 more
doaj   +1 more source

Role of prohibitins for proteolysis in yeast and murine mitochondria [PDF]

, 2006
Prohibitins, Phb1 and Phb2, are evolutionary conserved proteins with diverse cellular localization and different functions. In yeast, prohibitins form a high molecular weight complex in the inner mitochondrial membrane which physically interacts with the
Metodiev, Metodi Dimitrov
core  

On the role of bioactive sphingolipids and their metabolizing enzymes in cancer [PDF]

, 2017
Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas ...
Ahmed, Dilruba
core   +1 more source

Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma [PDF]

, 2015
ollicular adenoma is a type of benign and encapsulated nodule in the thyroid gland, but some adenomas have the potential to progress to follicular carcinoma. Therefore, it is important to monitor the state and progress of follicular adenoma in the clinic
Chen, Shaoxiong, Lai, Xianyin
core  

Breast cancer prognosis predicted by nuclear receptor-coregulator networks [PDF]

, 2014
Although molecular signatures based on transcript expression in breast cancer samples have provided new insights into breast cancer classification and prognosis, there are acknowledged limitations in current signatures. To provide rational, pathway-based
Clarke, Christine L., Clyne, Colin, Doan, Tram B., Eriksson, Natalie A., Fuller, Peter J., Funder, John W., Graham, Dinny, Kuczek, Elizabeth S., Leedman, Peter J., Muscat, George E. O., Simpson, Evan R., Tilley, Wayne D.   +11 more
core   +1 more source

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.

PLoS Genetics, 2012
Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Langer   +7 more
doaj   +1 more source

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Scientific Reports, 2017
Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-
Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka, Toyomasa Katagiri   +10 more
doaj   +1 more source