Results 101 to 110 of about 4,768 (180)

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease [PDF]

, 2014
It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes.
Kataoka, Masaharu, Wang, Da-Zhi
core   +2 more sources

Advances and Deep Insights Into Lactylation: Essential Roles in Cellular Regulation and Disease Association

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation is an important novel post‐translational modification (PTM) that can affect protein structure and function, playing a crucial role in signal transduction, gene expression and cellular metabolism.
Tong Pan, Can‐can Du, Ying‐jian Zhang, Zhen‐long Liu   +3 more
wiley   +1 more source

Prohibitin (PHB) expression is associated with aggressiveness in DLBCL and flavagline-mediated inhibition of cytoplasmic PHB functions induces anti-tumor effects

Journal of Experimental & Clinical Cancer Research, 2019
Background Diffuse large B-cell lymphomas (DLBCLs) are aggressive lymphomas accounting for approximately a third of non-Hodgkin lymphomas. Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are scaffold proteins that promote mitochondria homeostasis and ...
Hafidha Bentayeb, Marine Aitamer, Barbara Petit, Lydie Dubanet, Sabria Elderwish, Laurent Désaubry, Armand de Gramont, Eric Raymond, Agnès Olivrie, Julie Abraham, Marie-Odile Jauberteau, Danielle Troutaud   +11 more
doaj   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source

Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells

Journal of Dairy Science
: Mitochondrial dysfunction has been reported to occur in the mammary gland of dairy cows suffering from ketosis. Prohibitin 2 (PHB2) plays a crucial role in regulating mitophagy, which clears impaired mitochondria to maintain normal mitochondrial ...
Guojin Li, Liguang Cao, Kai Liu, Yifei Dong, Zifeng Yang, Jianchun Luo, Wenrui Gao, Lin Lei, Yuxiang Song, Xiliang Du, Xinwei Li, Wenwen Gao, Guowen Liu   +12 more
doaj   +1 more source

Role of prohibitins for proteolysis in yeast and murine mitochondria [PDF]

, 2006
Prohibitins, Phb1 and Phb2, are evolutionary conserved proteins with diverse cellular localization and different functions. In yeast, prohibitins form a high molecular weight complex in the inner mitochondrial membrane which physically interacts with the
Metodiev, Metodi Dimitrov
core  

Epithelial Atg5 Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During Pseudomonas Infection

MedComm, Volume 6, Issue 7, July 2025.
This work illuminates the essential role of epithelial ATG5 in defending against P. aeruginosa. Atg5 deficiency impairs bacterial clearance and aggravates inflammation via AKT/PI3K/NF‐κB, inflammasome activation, and pyroptosis. Mechanistically, impaired mitophagy intensifies mitochondrial damage.
Junyi Wang, Lei Zhang, Yingying Liu, Yao Liu, Anying Xiong, Qin Ran, Xiang He, Vincent Kam Wai Wong, Colin Combs, Guoping Li, Min Wu   +10 more
wiley   +1 more source

Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics

International Journal of Medical Sciences
This study aims to elucidate the roles of Phosphoglycerate Mutase Family Member 5 (Pgam5) and Prohibitin 2 (Phb2) in the context of hyperglycemia-induced myocardial dysfunction, a critical aspect of diabetic cardiomyopathy. The research employed primary cardiomyocytes, which were then subjected to hyperglycemia treatment to mimic diabetic conditions ...
Chen, Yingzhen, Huang, Jungang, Zhou, Hao, Lin, Jianguo, Tao, Jun   +4 more
openaire   +2 more sources

Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. [PDF]

, 2016
Published onlineJournal ArticleReviewSince its emergence in the 1990s, White Spot Disease (WSD) has had major economic and societal impact in the crustacean aquaculture sector.
Bateman, KS, Bickley, LK, Santos, EM, Stentiford, GD, Tyler, CR, van Aerle, R, Verbruggen, B   +6 more
core   +2 more sources