Results 111 to 120 of about 4,768 (180)

On the role of bioactive sphingolipids and their metabolizing enzymes in cancer [PDF]

, 2017
Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas ...
Ahmed, Dilruba
core   +1 more source

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.

PLoS Genetics, 2012
Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Langer   +7 more
doaj   +1 more source

Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma [PDF]

, 2015
ollicular adenoma is a type of benign and encapsulated nodule in the thyroid gland, but some adenomas have the potential to progress to follicular carcinoma. Therefore, it is important to monitor the state and progress of follicular adenoma in the clinic
Chen, Shaoxiong, Lai, Xianyin
core  

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

Scientific Reports, 2017
Estradiol (E2) and the oestrogen receptor-alpha (ERα) signalling pathway play pivotal roles in the proliferative activity of breast cancer cells. Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-
Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka, Toyomasa Katagiri   +10 more
doaj   +1 more source

Breast cancer prognosis predicted by nuclear receptor-coregulator networks [PDF]

, 2014
Although molecular signatures based on transcript expression in breast cancer samples have provided new insights into breast cancer classification and prognosis, there are acknowledged limitations in current signatures. To provide rational, pathway-based
Clarke, Christine L., Clyne, Colin, Doan, Tram B., Eriksson, Natalie A., Fuller, Peter J., Funder, John W., Graham, Dinny, Kuczek, Elizabeth S., Leedman, Peter J., Muscat, George E. O., Simpson, Evan R., Tilley, Wayne D.   +11 more
core   +1 more source

Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiolipin dissociation in hepatocellular carcinoma

Redox Biology
Hepatocellular carcinoma (HCC) displays mitochondrial dysfunction characterized by disrupted redox homeostasis and cristae disorganization, yet the underlying molecular mechanisms are unclear.
Zhehua Shao, Xinnuo Yang, Binben Wang, Xuwen Wang, Duoduo Zhao, Bingchen Liu, Jinliang Nan   +6 more
doaj   +1 more source

Author Correction: Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy. [PDF]

Acta Pharmacol Sin
Wang L, Tang XQ, Shi Y, Li HM, Meng ZY, Chen H, Li XH, Chen YC, Liu H, Hong Y, Xu HH, Liu L, Zhao L, Han WN, Liu X, Zhang Y.   +15 more
europepmc   +2 more sources

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Cancer Communications, Volume 45, Issue 7, Page 722-727, July 2025.
Lea Järke, Saskia Weber‐Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer   +15 more
wiley   +1 more source

Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases

Cells, 2019
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria.
Anna Signorile, Giuseppe Sgaramella, Francesco Bellomo, Domenico De Rasmo   +3 more
doaj   +1 more source

GOLPH3 promotes glioma progression by enhancing PHB2-mediated autophagy.

American journal of cancer research
Due to the hypoxia and nutrient deficiency microenvironment, malignant glioma exhibits high autophagy activity and autophagy plays a significant role in the occurrence and development of glioma. However, the potential molecular mechanism of autophagy in glioma remains unknown. In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3),
Kai, Wang, Yanhua, Qi, Xu, Wang, Yushuai, Liu, Min, Zhao, Ding, Zhou, Yu, Zhang, Yan, Wang, Rutong, Yu, Xiuping, Zhou   +9 more
openaire   +1 more source