Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling. [PDF]
PLoS ONEProhibitin 1 (PHB1) and prohibitin 2 (PHB2) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. They are ubiquitously expressed and implicated in the regulation of cell proliferation, migration,
Mei Li +9 more
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PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway [PDF]
Open Life SciencesFibrosis is the primary cause of retinal detachment and visual decline. Here, we investigated the role of Prohibitin 2 (PHB2) in modulating fibrosis in ARPE-19 cells stimulated by transforming growth factor (TGF)-β2.
Chen Feng, Cai Xiaoxiao, Yu Ying
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PRKN regulates inner mitochondrial membrane PHB2 during mitophagy
Autophagy Reports, 2023 PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and ...
Shan Sun +6 more
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Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
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Prohibitin 2 ameliorates cisplatin-induced acute kidney injury by modulating mitochondrial homeostasis [PDF]
Frontiers in PhysiologyAcute kidney injury (AKI), associated with a major health burden globally, is frequently caused by nephrotoxic agents, specifically cisplatin. Prohibitin (PHB) 2, a highly conserved mitochondrial protein localized at the inner mitochondrial membrane, is ...
Qi Zhang +4 more
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Oxidative stress suppresses PHB2‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway
Journal of Diabetes InvestigationAims/Introduction Mitochondrial damage caused by oxidative stress is a main driver of pancreatic β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus.
Shan Liu +8 more
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PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4 [PDF]
Redox BiologyBackground: Aortic aneurysm/dissection (AAD) is a catastrophic vascular emergency with limited therapeutic options and poorly understood molecular underpinnings.
Shengjun Xiong +10 more
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Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells [PDF]
Communications BiologyAurora kinase A/AURKA is a serine/threonine kinase frequently overexpressed in cancer. Recent discoveries pointed to subcellular pools of AURKA, including at mitochondria.
Amel Djehal +7 more
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Role of PHB2 as a potential biomarker in pan-cancer: a multi-database analysis [PDF]
Scientific ReportsProhibitin2 (PHB2) is a mitochondrial endosomal protein that is closely linked to tumors; however, its specific molecular role remains unclear. Therefore, this study investigates the role of PHB2 in cancer.
Jingxin Zhang
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Virulence, 2022 The vegetative insecticidal proteins (Vip3A) secreted by some Bacillus thuringiensis (Bt) strains during vegetative growth are regarded as a new generation of insecticidal toxins. Like insecticidal crystal proteins, they are also used in transgenic crops
Baoju An +5 more
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