Results 11 to 20 of about 4,768 (180)

Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer

Cells, 2023
Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi, Lillie Lamont, Evelyn Liu, Sarina D. Murray, Xiangbing Meng, Shujie Yang   +5 more
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PRKN regulates inner mitochondrial membrane PHB2 during mitophagy

Autophagy Reports, 2023
PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and ...
Shan Sun, Hongfeng Wang, Qilian Ma, Ningning Li, Mian Cao, Kin Yip Tam, Zheng Ying   +6 more
doaj   +3 more sources

Oxidative stress suppresses PHB2‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway

Journal of Diabetes Investigation
Aims/Introduction Mitochondrial damage caused by oxidative stress is a main driver of pancreatic β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus.
Shan Liu, Rui Zhang, Lan Zhang, Aige Yang, Yuqing Guo, Lei Jiang, Huijuan Wang, Shunjiang Xu, Huimin Zhou   +8 more
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PHB2 affects the virulence of Vip3Aa to Sf9 cells through internalization and mitochondrial stability

Virulence, 2022
The vegetative insecticidal proteins (Vip3A) secreted by some Bacillus thuringiensis (Bt) strains during vegetative growth are regarded as a new generation of insecticidal toxins. Like insecticidal crystal proteins, they are also used in transgenic crops
Baoju An, Yizhuo Zhang, Xuelian Li, Xiaoyue Hou, Bing Yan, Jun Cai   +5 more
doaj   +3 more sources

PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation

Cell Death and Disease, 2023
The alteration of cellular energy metabolism is a hallmark of colorectal cancer (CRC). Accumulating evidence has suggested oxidative phosphorylation (OXPHOS) is upregulated to meet the demand for energy in tumor initiation and development.
Lin Ren, Li Meng, Jing Gao, Mingdian Lu, Chengyu Guo, Yunyun Li, Ziye Rong, Yan Ye   +7 more
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PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance

Research, 2022
Disruption of the mitochondrial quality surveillance (MQS) system contributes to mitochondrial dysfunction in diabetic cardiomyopathy (DCM). In this study, we observed that cardiac expression of phosphoglycerate mutase 5 (PGAM5), a mitochondrial Ser/Thr ...
Rongjun Zou, Jun Tao, Jie He, Chaojie Wang, Songtao Tan, Yu Xia, Xing Chang, Ruibing Li, Ge Wang, Hao Zhou, Xiaoping Fan   +10 more
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Nrf2/PHB2 alleviates mitochondrial damage and protects against Staphylococcus aureus‐induced acute lung injury

MedComm, 2023
Staphylococcus aureus (SA) is a major cause of sepsis, leading to acute lung injury (ALI) characterized by inflammation and oxidative stress. However, the role of the Nrf2/PHB2 pathway in SA‐induced ALI (SA‐ALI) remains unclear.
Si‐Hao Jin, Jiao‐Jiao Sun, Gang Liu, Li‐Juan Shen, Yuan Weng, Jin‐You Li, Min Chen, Ying‐Ying Wang, Zhi‐Qi Gao, Feng‐Juan Jiang, Sheng‐Peng Li, Dan Chen, Qing‐Feng Pang, Ya‐Xian Wu, Zhi‐Qiang Wang   +14 more
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Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection [PDF]

Viruses, 2020
Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children’s health.
Weitao Su, Shan Huang, Huimin Zhu, Bao Zhang, Xianbo Wu   +4 more
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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

Neural Regeneration Research, 2023
Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson's disease, but the regulatory mechanism remains elusive. Prohibitin-2 (PHB2) is a newly discovered autophagy receptor in the mitochondrial inner membrane, and ...
Yongjiang Zhang, Shiyi Yin, Run Song, Xiaoyi Lai, Mengmeng Shen, Jiannan Wu, Junqiang Yan   +6 more
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Upregulation of TIPE1 in tubular epithelial cell aggravates diabetic nephropathy by disrupting PHB2 mediated mitophagy

Redox Biology, 2022
Renal tubular epithelial cells (RTECs) are one of the most mitochondria-rich cell types, and are thus vulnerable to mitochondrial dysregulation, which is defined as a pivotal event in tubular damage in diabetic nephropathy (DN).
Lei Liu, Fang Bai, Hui Song, Rong Xiao, Yuzhen Wang, Huimin Yang, Xiaolei Ren, Shuangjie Li, Lifen Gao, Chunhong Ma, Xiangdong Yang, Xiaohong Liang   +11 more
doaj   +3 more sources