Results 21 to 30 of about 4,768 (180)

High glucose- or AGE-induced oxidative stress inhibits hippocampal neuronal mitophagy through the Keap1–Nrf2–PHB2 pathway in diabetic encephalopathy [PDF]

Scientific Reports
Diabetic encephalopathy (DE) is a severe complication of diabetes, but its pathogenesis remains unclear. This study aimed to investigate the roles and underlying mechanisms of high glucose (HG)- and advanced glycosylation end product (AGE)-induced ...
Shan Xu, Zhaoyu Gao, Lei Jiang, Jiazheng Li, Yushi Qin, Di Zhang, Pei Tian, Wanchang Wang, Nan Zhang, Rui Zhang, Shunjiang Xu   +10 more
doaj   +2 more sources

Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway

iScience
Summary: Despite advances in treatment, myocardial infarction remains the leading cause of heart failure and death worldwide, and the restoration of coronary blood flow can also cause heart damage.
Jun Zhang, Yongjian Zhao, Lin Yan, Mingyue Tan, Yifeng Jin, Yunfei Yin, Lianhua Han, Xiao Ma, Yimin Li, Tianke Yang, Tingbo Jiang, Hongxia Li   +11 more
doaj   +3 more sources

Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy [PDF]

Journal of Advanced Research
Introduction: Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. Objectives: This study highlights the potential of Astragaloside IV(AS) in the treatment of septic cardiomyopathy and provides a reference ...
Junyan Wang, Xiangyi Pu, Haowen Zhuang, Zhijiang Guo, Mengyuan Wang, Huaihong Yang, Chun Li, Xing Chang   +7 more
doaj   +2 more sources

Identification and characterization of a novel small viral peptide (VSP59) encoded by Bombyx mori cypovirus (BmCPV) that negatively regulates viral replication [PDF]

Microbiology Spectrum
Bombyx mori cypovirus (BmCPV), a member of the Reoviridae family, is a well-established research model for double-stranded RNA (dsRNA) viruses with segmented genomes. Despite its small genome size, the coding potential of BmCPV remains largely unexplored.
Manman Cao, Qunnan Qiu, Xing Zhang, Wenxue Zhang, Zeen Shen, Chang Ma, Min Zhu, Jun Pan, Xingyu Tong, Guangli Cao, Chengliang Gong, Xiaolong Hu   +11 more
doaj   +2 more sources

Disruption of Mitochondrial Dynamics and Integrity Drives Divergent Metabolic Flexibility and Resilience in Podocytes. [PDF]

FASEB J
We investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Özel C, Reitmeier KM, Kieckhöfer E, Abualia K, Nguyen-Minh D, Matin M, Hagmann H, Coward RJM, Brähler S, Antczak P, Schermer B, Benzing T, Giavalisco P, Brinkkoetter PT.   +13 more
europepmc   +2 more sources

PHB2 ameliorates Doxorubicin-induced cardiomyopathy through interaction with NDUFV2 and restoration of mitochondrial complex I function

Redox Biology, 2023
Background: Doxorubicin (DOX) is among the most widely employed antitumor agents, although its clinical applications have been largely hindered by severe cardiotoxicity.
Mingjie Yang, Miyesaier Abudureyimu, Xiang Wang, Yuan Zhou, Yingmei Zhang, Jun Ren   +5 more
doaj   +1 more source

Defining functional classes of Barth syndrome mutation in humans [PDF]

, 2016
The X-linked disease Barth syndrome (BTHS) is caused by mutations in TAZ; TAZ is the main determinant of the final acyl chain composition of the mitochondrial-specific phospholipid, cardiolipin.
Claypool, Steven M., Galbraith, Laura, Gottlieb, Eyal, Herndon, Jenny, Koehler, Carla M., Lu, Ya-Lin, Lu, Ya-Wen, Luyf, Angela, McCaffery, J.Michael, Pras-Raves, Mia, Van Kampen, Antoine, Vaz, Frederic M., Vervaart, Martin   +12 more
core   +12 more sources

BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells. [PDF]

PLoS ONE, 2015
We recently reported that brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) binds Prohibitin 2 (PHB2) in cytoplasm, thereby causing a loss of function of the PHB2 tumor suppressor in the nuclei of breast cancer cells.
Nam-Hee Kim, Tetsuro Yoshimaru, Yi-An Chen, Taisuke Matsuo, Masato Komatsu, Yasuo Miyoshi, Eiji Tanaka, Mitsunori Sasa, Kenji Mizuguchi, Toyomasa Katagiri   +9 more
doaj   +1 more source

Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference

Frontiers in Microbiology, 2023
PE_PGRS30 belongs to the PE_PGRS protein family and is characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. PE_PGRS30 is a virulence factor of Mycobacterium tuberculosis that induces macrophage cell
Kazunori Matsumura, Satoshi Takaki, Teruo Kirikae   +2 more
doaj   +1 more source

PHB2 Protects Sister-Chromatid Cohesion in Mitosis [PDF]

Current Biology, 2007
Cohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1-4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5].
Takata, Hideaki, Matsunaga, Sachihiro, Morimoto, Akihiro, Ma, Nan, Kurihara, Daisuke, Ono-Maniwa, Rika, Nakagawa, Masatoshi, Azuma, Takachika, Uchiyama, Susumu, Fukui, Kiichi   +9 more
openaire   +2 more sources