Results 31 to 40 of about 4,768 (180)

PHB2/prohibitin 2: An inner membrane mitophagy receptor [PDF]

Cell Research, 2017
Mitophagy, the selective autophagic elimination of mitochondria, is a conserved cellular process critical for maintaining normal cellular physiology, and defects in this process are associated with certain pathophysiologies. In a recently published paper, Wei et al. describe their discovery of a hitherto unexplored mechanism of marking mitochondria for
Vikramjit, Lahiri, Daniel J, Klionsky
openaire   +2 more sources

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Nature Communications, 2022
AbstractFerroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a variety of diseases. Currently, a majority of known ferroptosis inhibitors belong to either antioxidants or iron-chelators. Here we report a new ferroptosis inhibitor,
Wei Yang, Bo Mu, Jing You, Chenyu Tian, Huachao Bin, Zhiqiang Xu, Liting Zhang, Ronggang Ma, Ming Wu, Guo Zhang, Chong Huang, Linli Li, Zhenhua Shao, Lunzhi Dai, Laurent Désaubry, Shengyong Yang   +15 more
openaire   +5 more sources

PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer

Theranostics, 2021
Background: Lung cancer has the highest mortality rate among cancers worldwide, with non-small cell lung cancer (NSCLC) the most common type. Increasing evidence shows that PHB2 is highly expressed in other cancer types; however, the effects of PHB2 in NSCLC are currently poorly understood.
Wu, Bin, Chang, Ning, Xi, Hangtian, Xiong, Jie, Zhou, Ying, Wu, Yingtong, Wu, Shuo, Wang, Ning, Yi, Hongyu, Song, Yun, Chen, Lihua, Zhang, Jian   +11 more
openaire   +2 more sources

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling

Antioxidants, 2023
Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang, Yeqing Zheng, Gaowa Bao, Wenzhuo Ma, Bing Han, Hongwen Shi, Zhenghang Zhao   +6 more
doaj   +1 more source

Knockdown of prohibitin 2 promotes apoptosis in non-small cell lung cancer cell line A549 [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were
ZHANG Jing, YANG Zigeng, WEI Hongmei, NING Haihong, XUE Xixi, JIN Ling, WU Bin
doaj   +1 more source

Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens [PDF]

Oncogene, 2004
Early diagnosis of cancer is crucial for successful treatment. Noninvasive assays for detecting tumor-derived antigens in serum and other bodily fluids have the potential to screen healthy individuals for hitherto undetected cancers. Very few such assays have been successfully developed, in part because identifying potential target antigens remains a ...
Mengwasser, J., Piau, A., Schlag, P., Sleeman, J. P.   +3 more
openaire   +3 more sources

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
doaj   +1 more source

LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis. [PDF]

Gut
Li H, Song M, Hylemon PB, Zhou H.
europepmc   +3 more sources

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo, Jae-Hyun Park, Jung-Won Kim, Meng-Lay Lin, Miki Akiyama, Tatsuhiko Tsunoda, Tomomi Ueki, Toshihiko Nishidate, Toyomasa Katagiri, Yataro Daigo, Yusuke Nakamura   +10 more
core   +2 more sources

Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]

, 2017
Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui, Chandel, Navdeep S, DeBerardinis, Ralph J, Dickerson, Kathryn E, Gu, Zhimin, Hu, Zeping, Li, Dan, Li, Mushan, Liu, Xin, Ni, Min, Shao, Zhen, Signer, Robert AJ, Weinberg, Samuel E, Xu, Jian, Zhang, Yuannyu, Zhou, Feng   +15 more
core   +1 more source