PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer
Theranostics, 2021 Background: Lung cancer has the highest mortality rate among cancers worldwide, with non-small cell lung cancer (NSCLC) the most common type. Increasing evidence shows that PHB2 is highly expressed in other cancer types; however, the effects of PHB2 in NSCLC are currently poorly understood.
Wu, Bin +11 more
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LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis. [PDF]
GutLi H, Song M, Hylemon PB, Zhou H.
europepmc +3 more sources
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2
Life Science Alliance, 2021 The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Giulia Bertolin +6 more
doaj +1 more source
Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens [PDF]
Oncogene, 2004 Early diagnosis of cancer is crucial for successful treatment. Noninvasive assays for detecting tumor-derived antigens in serum and other bodily fluids have the potential to screen healthy individuals for hitherto undetected cancers. Very few such assays have been successfully developed, in part because identifying potential target antigens remains a ...
Mengwasser, J. +3 more
openaire +3 more sources
Knockdown of prohibitin 2 promotes apoptosis in non-small cell lung cancer cell line A549 [PDF]
Jichu yixue yu linchuang, 2023 Objective To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were
ZHANG Jing, YANG Zigeng, WEI Hongmei, NING Haihong, XUE Xixi, JIN Ling, WU Bin
doaj +1 more source
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. [PDF]
, 2017 Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype.
Cao, Hui +15 more
core +1 more source
Antioxidants, 2023 Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang +6 more
doaj +1 more source
Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]
, 2009 Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo +10 more
core +2 more sources
Formononetin Inhibits Hepatic I/R‐Induced Injury through Regulating PHB2/PINK1/Parkin Pathway
Oxidative Medicine and Cellular Longevity, 2022 Formononetin (FN), an isoflavone compound mainly isolated from soy and red clover, had showed its anti‐inflammation, antioxidative effects in some degenerative diseases and cholestasis. However, the role of FN in protecting ischemia/reperfusion‐ (I/R‐) induced liver injury and the possible mechanism were unclear.
Zhongying Ma +10 more
openaire +2 more sources
Pathogens, 2020 Prohibitin 2 (PHB2), an inner mitochondrial membrane (IMM) protein, has recently been identified as a novel receptor involved in parkin-mediated mitophagy.
Francesca De Falco +5 more
doaj +1 more source