Results 41 to 50 of about 4,768 (180)
Formononetin Inhibits Hepatic I/R‐Induced Injury through Regulating PHB2/PINK1/Parkin Pathway
Oxidative Medicine and Cellular Longevity, 2022 Formononetin (FN), an isoflavone compound mainly isolated from soy and red clover, had showed its anti‐inflammation, antioxidative effects in some degenerative diseases and cholestasis. However, the role of FN in protecting ischemia/reperfusion‐ (I/R‐) induced liver injury and the possible mechanism were unclear.
Zhongying Ma +10 more
openaire +2 more sources
Pathogens, 2020 Prohibitin 2 (PHB2), an inner mitochondrial membrane (IMM) protein, has recently been identified as a novel receptor involved in parkin-mediated mitophagy.
Francesca De Falco +5 more
doaj +1 more source
Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells [PDF]
Nature Communications, 2013 The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3-PHB2 complex has a crucial role in the modulation of oestrogen/ERα signalling in breast cancer cells.
Yoshimaru, Tetsuro +15 more
openaire +2 more sources
Prohibitin and mitochondrial biology [PDF]
, 2009 8 pages, 2 figures.--PMID: 19733482 [PubMed]Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2.
Artal-Sanz, Marta +1 more
core +1 more source
Expression of PHB2 in Rat Brain Cortex Following Traumatic Brain Injury [PDF]
International Journal of Molecular Sciences, 2014 Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2. PHB2 is present in various cellular compartments including the nucleus and mitochondria.
Xu, Ting +5 more
openaire +2 more sources
Rutin attenuates oxidative stress via PHB2-mediated mitophagy in MPP + - induced SH-SY5Y cells
Neurotoxicity Research, 2022 Abstract Background and Purpose Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. This study aimed to investigate the neuroprotective effect and mechanism of rutin in PD.
Xiaoyi, Lai +5 more
openaire +2 more sources
Network rewiring is an important mechanism of gene essentiality change. [PDF]
, 2012 Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the ...
Bowie, James U +4 more
core +1 more source
Genetic basis of human circadian rhythm disorders. [PDF]
, 2013 Circadian rhythm disorders constitute a group of phenotypes that usually present as altered sleep-wake schedules. Until a human genetics approach was applied to investigate these traits, the genetic components regulating human circadian rhythm and sleep ...
Fu, Ying-Hui +3 more
core +2 more sources
SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. [PDF]
, 2016 Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested.
Andrade, Bruno +7 more
core +7 more sources
Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. [PDF]
, 2013 IntroductionThe purpose of this study is to identify target proteins that may play important functional roles in oral cancer stem-like cells (CSCs) using mass spectrometry-based quantitative proteomics.MethodsSphere-formation assays were performed on ...
Feng, Sizhe +3 more
core +1 more source