PLoS ONE, 2014 BackgroundThe pluripotent state of embryonic stem (ES) cells is controlled by a network of specific transcription factors. Recent studies also suggested the significant contribution of mitochondria on the regulation of pluripotent stem cells.
Megumi Kowno +19 more
doaj +1 more source
Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes [PDF]
, 2014 BACKGROUND: Identification of novel genetic risk factors is imperative for a better understanding of B lymphomagenesis and for the development of novel therapeutic strategies.
Carissa R Moore +6 more
core +1 more source
Inhibitors of Pyruvate Carboxylase [PDF]
, 2010 This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase.
Attwood, Paul V. +2 more
core +2 more sources
PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106–126 via PINK1/Parkin-Dependent Mitophagy
International Journal of Molecular Sciences, 2023 Prion diseases are a group of neurodegenerative diseases characterized by mitochondrial dysfunction and neuronal death. Mitophagy is a selective form of macroautophagy that clears injured mitochondria. Prohibitin 2 (PHB2) has been identified as a novel inner membrane mitophagy receptor that mediates mitophagy.
Zheng, Xiaohui +7 more
openaire +2 more sources
A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation [PDF]
, 2016 We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines.
Albericio Palomera, Fernando +15 more
core +1 more source
Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion [PDF]
, 2009 Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes. Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the fusion of mammalian mitochondria.
David C. Chan +5 more
core +2 more sources
The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]
, 2020 Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core +1 more source
Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]
, 2017 Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia +4 more
core +2 more sources
Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: role of synaptic mitochondria [PDF]
, 2017 Tau protein in dendrites and synapses has been recently implicated in synaptic degeneration and neuronal malfunction. Chronic stress, awell-known inducer of neuronal/synaptic atrophy, triggers hyperphosphorylation of Tau protein and cognitive deficits.
Atlante +17 more
core +1 more source
ASURA (PHB2) Is Required for Kinetochore Assembly and Subsequent Chromosome Congression
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2011 ASURA (PHB2) knockdown has been known to cause premature loss of sister chromatid cohesion, and disrupt the localization of several outer plate proteins to the kinetochore. As a result, cells are arrested at mitotic phase and chromosomes fail to congress to the metaphase plate. In this study, we further clarified the mechanism underlying ASURA function
Lee, Mei Hann +5 more
openaire +3 more sources