Results 51 to 60 of about 4,788 (163)
The Role of Prohibitin-2 in Diseases
Frontiers in Bioscience-Landmark, 2023 Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis.
Fang Liu +3 more
doaj +1 more source
Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells [PDF]
Nature Communications, 2013 The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3-PHB2 complex has a crucial role in the modulation of oestrogen/ERα signalling in breast cancer cells.
Yoshimaru, Tetsuro +15 more
openaire +2 more sources
Prohibitin and mitochondrial biology [PDF]
, 2009 8 pages, 2 figures.--PMID: 19733482 [PubMed]Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2.
Artal-Sanz, Marta +1 more
core +1 more source
Expression of PHB2 in Rat Brain Cortex Following Traumatic Brain Injury [PDF]
International Journal of Molecular Sciences, 2014 Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2. PHB2 is present in various cellular compartments including the nucleus and mitochondria.
Xu, Ting +5 more
openaire +2 more sources
Rutin attenuates oxidative stress via PHB2-mediated mitophagy in MPP + - induced SH-SY5Y cells
Neurotoxicity Research, 2022 Abstract Background and Purpose Oxidative stress plays a crucial role in the occurrence and development of Parkinson's disease (PD). Rutin, a natural botanical ingredient, has been shown to have antioxidant properties. This study aimed to investigate the neuroprotective effect and mechanism of rutin in PD.
Xiaoyi, Lai +5 more
openaire +2 more sources
Network rewiring is an important mechanism of gene essentiality change. [PDF]
, 2012 Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the ...
Bowie, James U +4 more
core +1 more source
SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. [PDF]
, 2016 Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested.
Andrade, Bruno +7 more
core +7 more sources
PLoS ONE, 2014 BackgroundThe pluripotent state of embryonic stem (ES) cells is controlled by a network of specific transcription factors. Recent studies also suggested the significant contribution of mitochondria on the regulation of pluripotent stem cells.
Megumi Kowno +19 more
doaj +1 more source
Genetic basis of human circadian rhythm disorders. [PDF]
, 2013 Circadian rhythm disorders constitute a group of phenotypes that usually present as altered sleep-wake schedules. Until a human genetics approach was applied to investigate these traits, the genetic components regulating human circadian rhythm and sleep ...
Fu, Ying-Hui +3 more
core +2 more sources
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
doaj +1 more source