Results 81 to 90 of about 4,768 (180)

Mammalian mitophagy – from in vitro molecules to in vivo models [PDF]

, 2017
The autophagic turnover of mitochondria, termed mitophagy, is thought to play an essential role in not only maintaining the health of the mitochondrial network, but also that of the cell and organism as a whole. We have come a long way in identifying the
Ganley, Ian G., McWilliams, Thomas G., Rodger, Catherine E.   +2 more
core   +2 more sources

LINC00478-derived novel cytoplasmic lncRNA LacRNA stabilizes PHB2 and suppresses breast cancer metastasis via repressing MYC targets

Journal of Translational Medicine, 2023
Background Metastasis is the predominant cause of mortality in patients with breast cancer. Long noncoding RNAs (lncRNAs) have been shown to drive important phenotypes in tumors, including invasion and metastasis.
Rong Guo, Yonghui Su, Qi Zhang, Bingqiu Xiu, Sheng Huang, Weiru Chi, Liyi Zhang, Lun Li, Jianjing Hou, Jia Wang, Jiajian Chen, Yayun Chi, Jingyan Xue, Jiong Wu   +13 more
doaj   +1 more source

Die höchsten Oxidationsstufen der Seltenerdelemente und die Probleme mit den Praseodym(+5)‐Verbindungen

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
Alle Seltenerdelemente bilden bekanntlich tri‐ und auch di‐valente Verbindungen. Wenige tetra‐valente Verbindungen sind auch bekannt; kürzlich wurden die ersten Moleküle und Kristalle mit Praseodym(+5) synthetisiert. Der hier definierte atomare Ionisations‐Quotient IQ legt nahe, dass Ln(+4)‐Verbindungen mit geeigneten Liganden für fast alle 4f‐Elemente
Lian‐Wei Ye, Wilhelm Hans Eugen Schwarz, Jun Li   +2 more
wiley   +1 more source

Non-polyadenylated transcription in embryonic stem cells reveals novel non-coding RNA related to pluripotency and differentiation [PDF]

, 2013
The transcriptional landscape in embryonic stem cells (ESCs) and during ESC differentiation has received considerable attention, albeit mostly confined to the polyadenylated fraction of RNA, whereas the non-polyadenylated (NPA) fraction remained largely ...
Duttagupta, R., Gingeras, T. R., Harikumar, A., Livyatan, I., Meshorer, E., Nissim-Rafinia, M.   +5 more
core   +1 more source

The Highest Oxidation States of the Rare‐Earth Elements and the Challenge of Praseodymium(+5) Compounds

Angewandte Chemie International Edition, Volume 65, Issue 1, 2 January 2026.
Rare Earth Elements are known to form tri‐ and also di‐valent compounds. A few tetra‐valent compounds are also known, and recently the first molecules and crystals with Praseodymium(+5) were synthesized. By defining the atomic Ionization Quotient IQ, Ln(+4) compounds with suitable ligands appear possible for almost all 4f elements, while Pr(+5) may ...
Lian‐Wei Ye, W.H.Eugen Schwarz, Jun Li
wiley   +1 more source

Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley   +1 more source

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa [PDF]

, 2018
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
A Criollo, A Hamacher-Brady, A Hamacher-Brady, A Rita Di, A Rita Di, A Rozenknop, A Sali, A Sprenger, A Stolz, A Tanaka, AY Abramov, B Richter, C Margreitter, D Knight, DW Choi, EM Valente, F Strappazzon, F Strappazzon, F Strappazzon, F Strappazzon, G Ashrafi, G Xu, GA Khoury, GP Leboucher, H Sandoval, H Tomita, H Zhou, I Matic, I Novak, J Kitchen, JJ Lemasters, JL Parsons, JM Heo, K Sugawara, K Yamano, L Liu, LA Kane, M Campanella, M Karbowski, M Laforge, M Lazarou, M Pasi, M Pilli, M Tiberti, M Tiberti, MJ Abraham, MP Williamson, N Bakkar, N Shembade, NC Chan, P Bjelkmar, P Wild, Q Zhong, RK Dagda, S Inoue, S Piana, T Kitada, T Murakawa, T Tatsuta, TN Nguyen, V Cianfanelli, VV Rogov, VV Rogov, VV Rogov, W Zhang, Y Chen, Y Ichimura, Y Wei, Y Xue, Y Yuan, Y Zhu   +70 more
core   +4 more sources

MicroRNA-24-3p alleviates cardiac fibrosis by suppressing cardiac fibroblasts mitophagy via downregulating PHB2

Pharmacological Research, 2022
Cardiac fibrosis is a pathological process of multiple cardiovascular diseases, which may lead to heart failure. Studies have shown that microRNAs (miRNAs) play critical roles in regulating mitophagy and cardiac fibrosis. We found that miR-24-3p expression was significantly downregulated in transverse aortic constriction (TAC) mice and cardiac ...
Yue Zhang, Zhiying Wang, Dingming Lan, Jingjing Zhao, Lexun Wang, Xiaoqi Shao, Dongwei Wang, Kaili Wu, Mengxian Sun, Xueying Huang, Meiling Yan, Haihai Liang, Xianglu Rong, Hongtao Diao, Jiao Guo   +14 more
openaire   +3 more sources

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen, Jinsi Chen, Li Huang, Xingqiang Lai, Kai Xia, Qiying Lu, Bingbing Xie, Yinong Huang, Yuan Qiu, Tao Wang, Jianqi Feng, Yuanjun Guan, Siyao Che, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? [PDF]

, 2012
Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS).
Chen, GW, Chen, H, Martin-DeLeon, PA, O, WS, Ou, JX, Shi, HJ, Wang, MJ, Wu, JP   +7 more
core   +1 more source