Results 81 to 90 of about 4,788 (163)

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa [PDF]

, 2018
The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
A Criollo, A Hamacher-Brady, A Hamacher-Brady, A Rita Di, A Rita Di, A Rozenknop, A Sali, A Sprenger, A Stolz, A Tanaka, AY Abramov, B Richter, C Margreitter, D Knight, DW Choi, EM Valente, F Strappazzon, F Strappazzon, F Strappazzon, F Strappazzon, G Ashrafi, G Xu, GA Khoury, GP Leboucher, H Sandoval, H Tomita, H Zhou, I Matic, I Novak, J Kitchen, JJ Lemasters, JL Parsons, JM Heo, K Sugawara, K Yamano, L Liu, LA Kane, M Campanella, M Karbowski, M Laforge, M Lazarou, M Pasi, M Pilli, M Tiberti, M Tiberti, MJ Abraham, MP Williamson, N Bakkar, N Shembade, NC Chan, P Bjelkmar, P Wild, Q Zhong, RK Dagda, S Inoue, S Piana, T Kitada, T Murakawa, T Tatsuta, TN Nguyen, V Cianfanelli, VV Rogov, VV Rogov, VV Rogov, W Zhang, Y Chen, Y Ichimura, Y Wei, Y Xue, Y Yuan, Y Zhu   +70 more
core   +4 more sources

PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis [PDF]

Autophagy, 2019
Mitophagy, which is a conserved cellular process for selectively removing damaged or unwanted mitochondria, is critical for mitochondrial quality control and the maintenance of normal cellular physiology. However, the precise mechanisms underlying mitophagy remain largely unknown.
Chaojun Yan, Longlong Gong, Li Chen, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Désaubry, Zhiyin Song   +7 more
openaire   +2 more sources

Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease [PDF]

, 2014
It has been recognized for decades that proteins, which are encoded by our genome and produced via transcription and translation steps, are building blocks that play vital roles in almost all biological processes.
Kataoka, Masaharu, Wang, Da-Zhi
core   +2 more sources

Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility? [PDF]

, 2012
Prohibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS).
Chen, GW, Chen, H, Martin-DeLeon, PA, O, WS, Ou, JX, Shi, HJ, Wang, MJ, Wu, JP   +7 more
core   +1 more source

Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin‐2 dephosphorylation and impairing mitochondrial quality control

Clinical and Translational Medicine
Background The induction of mitochondrial quality control (MQC) mechanisms is essential for the re‐establishment of mitochondrial homeostasis and cellular bioenergetics during periods of stress.
Jun Tao, Junxiong Qiu, Junmeng Zheng, Ruibing Li, Xing Chang, Qingyong He   +5 more
doaj   +1 more source

Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure

EMBO Molecular Medicine, 2015
Mitochondrial dysfunction and alterations in energy metabolism have been implicated in a variety of human diseases. Mitochondrial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin‐2 (
Christina Ising, Sybille Koehler, Sebastian Brähler, Carsten Merkwirth, Martin Höhne, Olivier R Baris, Henning Hagmann, Martin Kann, Francesca Fabretti, Claudia Dafinger, Wilhelm Bloch, Bernhard Schermer, Andreas Linkermann, Jens C Brüning, Christine E Kurschat, Roman‐Ulrich Müller, Rudolf J Wiesner, Thomas Langer, Thomas Benzing, Paul Thomas Brinkkoetter   +19 more
doaj   +1 more source

PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

Biomedicines, 2020
Multiple sclerosis (MS) is an autoimmune disease in which activated lymphocytes affect the central nervous system. Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been reported ...
Domenico De Rasmo, Anna Ferretta, Silvia Russo, Maddalena Ruggieri, Piergiorgio Lasorella, Damiano Paolicelli, Maria Trojano, Anna Signorile   +7 more
doaj   +1 more source

Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. [PDF]

, 2016
Published onlineJournal ArticleReviewSince its emergence in the 1990s, White Spot Disease (WSD) has had major economic and societal impact in the crustacean aquaculture sector.
Bateman, KS, Bickley, LK, Santos, EM, Stentiford, GD, Tyler, CR, van Aerle, R, Verbruggen, B   +6 more
core   +2 more sources

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major

Parasites & Vectors, 2018
Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos, Ana Karina Ibarrola-Vannucci, Isabel Díaz-Lozano, José Luis Ramírez, A. Osuna   +4 more
doaj   +1 more source

LncRNAs: the bridge linking RNA and colorectal cancer. [PDF]

, 2016
Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control ...
Chen, Yi, Deng, Xiangbing, Feng, Min, Lau, Bonnie, Lau, Wayne Bond, Le, Xiaobing, Lei, Lingzi, Luo, Zhongyue, Wang, Chenlu, Wei, Yuquan, Xu, Lian, Xuan, Yu, Yang, Huiliang, Yang, Qilian, Yang, Yanfei, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Shengtao   +18 more
core   +4 more sources