Results 1 to 10 of about 2,610 (113)

Physiological plasticity in zebra finch color varieties mitigates DNA damage under oxidative stress [PDF]

iScience
Summary: Melanins are fundamental vertebrate pigments. Pheomelanin synthesis utilizes cysteine, a precursor for the antioxidant glutathione. Sustained pheomelanin synthesis may thus reduce cysteine availability for antioxidant defenses, resulting in a ...
Cristiana I. Marques, Sol Rodríguez-Martínez, Pedro Miguel Araújo, Sandra Afonso, Mohammed Zougagh, Ángel Ríos, Miguel Carneiro, Ismael Galván   +7 more
doaj   +2 more sources

Blocking ASIP to Protect MC1R Signaling and Mitigate Melanoma Risk: An In Silico Study [PDF]

Pharmaceuticals
Background: Melanin protects skin and hair from the effects of ultraviolet (UV) radiation damage, which contributes to all forms of skin cancer, including melanoma.
Farah Maarfi, Mohammed Cherkaoui, Sana Afreen, Mohd Yasir Khan   +3 more
doaj   +2 more sources

Molecular insights into region-specific sexual dichromatism: Comparative transcriptome analysis of red cheek pigmentation in zebra finches. [PDF]

PLoS Genetics
Feathers, the primary skin appendage covering the avian body, undergo dynamic phenotypic changes throughout a bird's life. Males and females of the same species can exhibit sexually dichromatic plumage colors which play a critical role in mating choice ...
Gee-Way Lin, Chih-Kuan Chen, Ting-Xin Jiang, Ya-Chen Liang, Pin-Chi Tang, Ping Wu, Randall B Widelitz, Chih-Feng Chen, Cheng-Ming Chuong   +8 more
doaj   +2 more sources

Analysis of femoroacetabular impingement by a triade of label-free optical spectroscopy techniques [PDF]

Communications Biology
Understanding the biochemical mechanisms of hip joint diseases remains challenging. Femoroacetabular impingement (FAI) is a condition where developmental deformities of the hip joint reduce mobility and cause tissue damage, with characteristic red ...
Martin Hohmann, Lucas Kreiss, Faramarz Dehghani, Dongqin Ni, Max Gmelch, Oliver Friedrich, Lorenz Büchler, Michael Schmidt   +7 more
doaj   +2 more sources

Evaluation of guinea fowls by genetic markers of plumage color [PDF]

BIO Web of Conferences, 2023
The work was carried out at LLC “Genofond” of the Moscow region on gray-speckled, Zagorsk white-breasted, blue and cream guinea fowls of the VNITIP selection.
Roiter Ykov, Degtyareva Olga
doaj   +1 more source

Five genetic variants explain over 70% of hair coat pheomelanin intensity variation in purebred and mixed breed domestic dogs.

PLoS ONE, 2021
In mammals, the pigment molecule pheomelanin confers red and yellow color to hair, and the intensity of this coloration is caused by variation in the amount of pheomelanin.
Andrea J Slavney, Takeshi Kawakami, Meghan K Jensen, Thomas C Nelson, Aaron J Sams, Adam R Boyko   +5 more
doaj   +1 more source

Differential Induction of Reactive Oxygen Species and Expression of Antioxidant Enzymes in Human Melanocytes Correlate with Melanin Content: Implications on the Response to Solar UV and Melanoma Susceptibility

Antioxidants, 2022
Constitutive pigmentation determines the response to sun exposure and the risk for melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes, we compared the effects of constitutive pigmentation on their antioxidant response
Parth R. Upadhyay, Renny J. Starner, Viki B. Swope, Kazumasa Wakamatsu, Shosuke Ito, Zalfa A. Abdel-Malek   +5 more
doaj   +1 more source

Spiny mice modulate eumelanin to pheomelanin ratio to achieve cryptic coloration in "evolution canyon," Israel. [PDF]

PLoS ONE, 2010
Coat coloration in mammals is an explicit adaptation through natural selection. Camouflaging with the environment is the foremost evolutionary drive in explaining overall coloration. Decades of enquiries on this topic have been limited to repetitive coat
Natarajan Singaravelan, Tomas Pavlicek, Alex Beharav, Kazumasa Wakamatsu, Shosuke Ito, Eviatar Nevo   +5 more
doaj   +1 more source

A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken.

PLoS Genetics, 2023
The biochemical pathway regulating the synthesis of yellow/red pheomelanin is less well characterized than the synthesis of black/brown eumelanin. Inhibitor of gold (IG phenotype) is a plumage colour variant in chicken that provides an opportunity to ...
Huijuan Bi, Jonas Tranell, Dawn C Harper, Weifeng Lin, Jingyi Li, Anders R Hellström, Mårten Larsson, Carl-Johan Rubin, Chao Wang, Shumaila Sayyab, Susanne Kerje, Bertrand Bed'hom, David Gourichon, Shosuke Ito, Kazumasa Wakamatsu, Michèle Tixier-Boichard, Michael S Marks, Daniel Globisch, Leif Andersson   +18 more
doaj   +1 more source

Metabolic Basis and Clinical Evidence for Skin Lightening Effects of Thiol Compounds

Antioxidants, 2022
Melanin pigment is a major factor in determining the color of the skin, and its abnormal increase or decrease can cause serious pigmentation disorders.
Yong Chool Boo
doaj   +1 more source