Results 121 to 130 of about 8,721 (232)

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy.

Cell Metabolism, 2023
Duo Zhang, A. Li, Guanghui Hu, Menggui Huang, Fan Yang, Lin Zhang, K. Wellen, Xiaowei Xu, Crystal S. Conn, W. Zou, M. Kahn, Seth D. Rhoades, A. Weljie, Serge Y. Fuchs, N. Amankulor, D. Yoshor, Jiangbin Ye, C. Koumenis, Y. Gong, Yi Fan   +19 more
semanticscholar   +1 more source

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK [PDF]

, 2017
葡萄糖是生物中最基本、最主要的营养物质，它不仅是机体能量的主要来源，也是生物质合成的主要原料。因此，葡萄糖的水平对于生物体是极其重要的。然而，在生活中，体内葡萄糖水平的波动是十分常见的，这是因为我们不可能每时每刻都在摄入葡萄糖：睡一大觉、剧烈运动几个小时或者太忙了没时间吃饭，都会引起葡萄糖水平的显著下降。这时，机体能够触发一套有效的过程应对这类“不利情况”，其中最为关键的就是激活“代谢的核心调节”——AMPK。在葡萄糖水平下降时，被激活的AMPK能够迅速启动脂肪、蛋白质的分解代谢，关闭它们的合成代谢 ...
A Sols, AJ Morris, Alexander Gray, AW Kao, B Xiao, B Xiao, C Ritterson Lew, CG Langendorf, Chen-Song Zhang, CS Zhang, D Carling, D. Grahame Hardie, F Rago, FA Ran, FA Ross, G Kroemer, GR Steinberg, H Hu, Hai-Long Piao, Huiyong Yin, IP Salt, Jin-Wei Feng, Jiwen Cui, JS Oakhill, JW Dennis, KH Choi, L Alvarez-Erviti, M Forgac, M Lu, M Lu, M Lu, Mengqi Li, Mingjiang Zhu, MM Mihaylova, MR El-Maghrabi, PM Kelley, SA Hawley, Sheng-Cai Lin, Shu-Yong Lin, Simon A. Hawley, SV Costes, Teng Ma, Terytty Yang Li, TY Li, VP Houde, WA Wilson, Y Zhao, YL Zhang, Yu-Qing Wu, Yue Zong, Zhichao Wang, Zhiyun Ye   +51 more
core   +2 more sources

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma.

Journal of Clinical Investigation
comprehensive characterization of the role of the serine synthesis pathway in germinal center B cells lymphomas derived from these cells. We demonstrate that upregulation of a functional serine synthesis cell activation the center reaction.
A. D'Avola, Nathalie M. Legrave, Mylène Tajan, P. Chakravarty, Ryan L. Shearer, Hamish W. King, Katarina Kluckova, Eric C Cheung, A. Clear, Arief Gunawan, Lingling Zhang, Louisa K James, J. MacRae, John G. Gribben, D. Calado, K. Vousden, J. Riches   +16 more
semanticscholar   +1 more source

Decoding Key Nodes in the Metabolism of Cancer Cells: Sugar & Spice and All Things Nice [PDF]

, 2012
In the past 5 years, a convergence of studies has resulted in a broad appreciation in the cancer research community that reprogramming of cellular metabolism may be more central to cancer than appreciated in the past 30 years.
Cantley, Lewis C., Shaw, Reuben J.
core   +2 more sources

MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability

bioRxiv
Overexpression of PHGDH, the rate-limiting enzyme in the serine synthesis pathway, promotes melanomagenesis, melanoma cell proliferation, and survival of metastases in serine-low environments such as the brain.
Neel Jasani, Xiaonan Xu, Benjamin Posorske, Yumi Kim, Olga Vera, Kenneth Y. Tsai, G. DeNicola, F. Karreth   +7 more
semanticscholar   +1 more source

Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression. [PDF]

, 2015
To investigate metabolic changes during cellular transformation, we used a 1H NMR based metabolite-metabolite correlation analysis (MMCA) method, which permits analysis of homeostatic mechanisms in cells at the steady state, in an inducible cell ...
Griffiths, John R, Jauhiainen, Alexandra, Madhu, Basetti, Menon, Suraj, Narita, Masako, Narita, Masashi, Stubbs, Marion, Tavaré, Simon   +7 more
core   +2 more sources

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect

Molecular & Cellular Oncology, 2017
Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj   +1 more source

Differential expression of PHGDH in pancreatic cancer.

, 2023
Shahan Mamoor
openalex   +2 more sources

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]

, 2017
After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N, Chapman, Harold A, Driver, Ian H, Gotts, Jeffrey E, Jackson, Julia R, Kim, Thomas, Lee, Dong-Kee, Matthay, Michael A, Shannon, John M, Tan, Victor, Vaughan, Andrew E, Wei, Ying, Xi, Ying, Xu, Jianming   +13 more
core   +1 more source

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Nature, 2022
Matteo Rossi, P. Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, A. Vandekeere, Alejandro M. Cuadros, J. Fernández-García, Carla Riera-Domingo, C. Jauset, M. Planque, H. F. Alkan, David Nittner, D. Zuo, Lindsay A. Broadfield, S. Parik, A. A. Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, S. Teoh, A. Aurora, Panagiotis Karras, Ines Vermeire, D. Broekaert, Joke Van Elsen, M. Knott, M. Orth, S. Demeyer, G. Eelen, L. Dobrolecki, A. Bassez, T. Brussel, K. Sotlar, M. Lewis, H. Bartsch, M. Wuhrer, P. Veelen, P. Carmeliet, J. Cools, S. Morrison, J. Marine, D. Lambrechts, M. Mazzone, G. Hannon, Sophia Y. Lunt, T. Grünewald, Morag Park, J. Rheenen, S. Fendt   +50 more
semanticscholar   +1 more source