Results 121 to 130 of about 8,290 (226)
eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs [PDF]
, 2017 Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli.
Fijalkowska, Daria +5 more
core +1 more source
Decoding Key Nodes in the Metabolism of Cancer Cells: Sugar & Spice and All Things Nice [PDF]
, 2012 In the past 5 years, a convergence of studies has resulted in a broad appreciation in the cancer research community that reprogramming of cellular metabolism may be more central to cancer than appreciated in the past 30 years.
Cantley, Lewis C., Shaw, Reuben J.
core +2 more sources
RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma. [PDF]
Adv Sci (Weinh)AbstractChemoresistance represents a major challenge for osteosarcoma treatment. Despite the improved knowledge of cancer biology, the core determinants of cisplatin (DDP) resistance in osteosarcoma remain unclear and deserve further exploration. Here, RFWD3 is identified as a key regulator of DDP sensitivity in osteosarcoma using a genome‐wide CRISPR ...
Zhang W +6 more
europepmc +4 more sources
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. [PDF]
, 2017 After influenza infection, lineage-negative epithelial progenitors (LNEPs) exhibit a binary response to reconstitute epithelial barriers: activating a Notch-dependent ΔNp63/cytokeratin 5 (Krt5) remodelling program or differentiating into alveolar type II
Brumwell, Alexis N +13 more
core +1 more source
Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect
Molecular & Cellular Oncology, 2017 Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously ...
Jeff C. Kremer, Brian A. Van Tine
doaj +1 more source
PHGDH is required for germinal center formation and is a therapeutic target in MYC -driven lymphoma [PDF]
, 2021 Annalisa D’Avola +15 more
openalex +1 more source