Results 121 to 130 of about 8,013 (194)

Phosphoglycerate dehydrogenase (PHGDH) [PDF]

Science-Business eXchange, 2011
openaire   +3 more sources

MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury

Cell Discovery
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant clinical challenge in both diagnosis and treatment.
Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang   +6 more
doaj   +1 more source

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science
AbstractChemoresistance represents a major challenge for osteosarcoma treatment. Despite the improved knowledge of cancer biology, the core determinants of cisplatin (DDP) resistance in osteosarcoma remain unclear and deserve further exploration. Here, RFWD3 is identified as a key regulator of DDP sensitivity in osteosarcoma using a genome‐wide CRISPR ...
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
openaire   +3 more sources

FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma

Nature Communications
Cancer cells are often addicted to serine synthesis to support growth. How serine synthesis is regulated in cancer is not well understood. We recently demonstrated protein arginine methyltransferase 1 (PRMT1) is upregulated in hepatocellular carcinoma ...
Li Luo, Xingyun Wu, Jiawu Fan, Lixia Dong, Mao Wang, Yan Zeng, Sijia Li, Wenyong Yang, Jingwen Jiang, Kui Wang   +9 more
doaj   +1 more source

PHGDH Gene [PDF]

, 2020
openaire   +1 more source

PHGDH wt Allele [PDF]

, 2020
openaire   +1 more source

Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH

mBio
Classical swine fever virus (CSFV), an obligate intracellular pathogen, hijacks cellular metabolism to evade immune surveillance and facilitate its replication. The precise mechanisms by which CSFV modulates immune metabolism remain largely unknown.
Xiaowen Li, Yaoyao Huang, Xueyi Liu, Lihong Zhang, Xinyan Wang, Feifan Zhao, Linke Zou, Keke Wu, Wenxian Chen, Yuwei Qin, Sen Zeng, Bingke Li, Yintao He, Yiwan Song, Zhaoyao Li, Jindai Fan, Mingqiu Zhao, Lin Yi, Hongxing Ding, Shuangqi Fan, Jinding Chen   +20 more
doaj   +1 more source

ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis

Cell Death and Disease
Argininosuccinate synthase (ASS1), a critical enzyme in the urea cycle, acts as a tumor suppressor in many cancers. To date, the anticancer mechanism of ASS1 has not been fully elucidated. Here, we found that phosphoglycerate dehydrogenase (PHGDH), a key
Wensong Luo, Zizheng Zou, Yuan Nie, Junli Luo, Zhengnan Ming, Xiyuan Hu, Tiao Luo, Min Ouyang, Mingquan Liu, Huicheng Tang, Yuanzhu Xie, Kunjian Peng, Ling Chen, Jiang Zhou, Zhiyong Luo   +14 more
doaj   +1 more source

Identification of novel PHGDH inhibitors based on computational investigation: an all-in-one combination strategy to develop potential anti-cancer candidates

Frontiers in Pharmacology
ObjectiveBiological studies have elucidated that phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway in humans that is abnormally expressed in numerous cancers. Inhibition of the PHGDH activity is thought to
Yujing Xu, Zhe Yang, Jinrong Yang, Chunchun Gan, Nan Qin, Xiaopeng Wei   +5 more
doaj   +1 more source

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway

International Journal of General Medicine
Yuhai Zou,1,* Dongdong Li,1,* Ge Guan,1 Wenting Liu2 1Department of Cardiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, People’s Republic of China; 2Department of Otorhinolaryngology, Guangzhou First People’s ...
Zou Y, Li D, Guan G, Liu W
doaj