Results 131 to 140 of about 8,721 (232)

PHGDH Inhibitor CBR‐5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β‐Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib [PDF]

, 2022
Xiaocui Zhang, Meige Sun, Yisheng Jiao, Bei Lin, Qing Yang   +4 more
openalex   +1 more source

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells

Biochemistry and Biophysics Reports, 2019
Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is ...
Madelaine C. Brearley, Congcong Li, Zoe C.T.R. Daniel, Paul T. Loughna, Tim Parr, John M. Brameld   +5 more
doaj   +1 more source

MP51-05 PHGDH CAN BE A THERAPEUTIC TARGET IN BLADDER CANCER [PDF]

, 2019
Yoichi Osako, Hirofumi Yoshino, Masaya Yonemori, Shuichi Tatarano, Hideki Enokida, Masayuki Nakagawa   +5 more
openalex   +1 more source

Data from RETRACTED: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

, 2023
Debangshu Samanta, Youngrok Park, Shaida A. Andrabi, Laura M. Shelton, Daniele M. Gilkes, Gregg L. Semenza   +5 more
openalex   +1 more source

FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma

Nature Communications
Cancer cells are often addicted to serine synthesis to support growth. How serine synthesis is regulated in cancer is not well understood. We recently demonstrated protein arginine methyltransferase 1 (PRMT1) is upregulated in hepatocellular carcinoma ...
Li Luo, Xingyun Wu, Jiawu Fan, Lixia Dong, Mao Wang, Yan Zeng, Sijia Li, Wenyong Yang, Jingwen Jiang, Kui Wang   +9 more
doaj   +1 more source

Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition

, 2020
Mai Q. Nguyen, Jessica L.F. Teh, Timothy J. Purwin, Inna Chervoneva, Michael A. Davies, Katherine L. Nathanson, Phil F. Cheng, Mitchell P. Levesque, Reinhard Dummer, Andrew E. Aplin   +9 more
openalex   +2 more sources

Faculty Opinions recommendation of Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism.

, 2019
Hans van Beek
openalex   +2 more sources

UEG Week 2025 Moderated Posters

United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
wiley   +1 more source

YY2/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis

, 2023
Juan Li, Xinxin Luo, Mankun Wei, Zhuolin Li, Yanjun Li, Hezhao Zhao, Makoto Miyagishi, Vivi Kasim, Shourong Wu   +8 more
openalex   +1 more source

PO-267 PHGDH and PSAT confer metabolic vulnerability to IDH2-driven reprogramming in breast cancer [PDF]

, 2018
Georgina D. Barnabas, Michael Selitrennik, Michal Harel, J.S. Lee, Yair Pozniak, Livnat Jerby Arnon, Eyal Gottlieb, Eytan Ruppin, Tamar Geiger   +8 more
openalex   +1 more source