Results 171 to 180 of about 8,013 (194)

Multi-Omics Analysis and Real-World Data Validation of Serine Metabolism-Related Genes in Colorectal Cancer. [PDF]

J Cell Mol Med
Li A, Wu Q, Xu Y, Gu Y, Wang X, Liu J, Wang Y, Xie J, Fu X, Li Y.   +9 more
europepmc   +1 more source

Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zhao YH, Ning JH, Zhang X, Qu R, Lv CC, Zhang YZ.   +5 more
europepmc   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study. [PDF]

Epilepsia
Thevissen K, Ny A, Copmans D, Tits J, Kamata K, Gielis E, Longin K, Sourbron J, Thergarajan P, Tan TH, Ali I, Jones NC, O'Brien TJ, Monif M, Semple BD, Germeys C, Frizzi B, Minniti V, Perrone S, Linster CL, Elia I, Van Den Bosch L, Cammue BPA, Voet A, Lagae L, de Witte P.   +25 more
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ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis. [PDF]

Cell Biosci
Zhu J, Ren S, Yi Y, Wu Z, Lin H, Shan G, Huang X, Pan B, Hu Z, Sui Q, Zhan C, Wang S, Liang J.   +12 more
europepmc   +1 more source

Nutrient requirements of organ-specific metastasis in breast cancer. [PDF]

Nature
Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Ramesh DL, Honeder SE, Kumar AS, Wu M, Hansen JA, Shevzov-Zebrun A, Rashan EH, Eghbalian KM, Sivanand S, Barbeau AM, Riedmayr LM, Duquette M, Ali A, Henning N, Trojan SE, Waite M, Kunchok T, Nakano MA, Gourgue F, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG.   +32 more
europepmc   +1 more source

Species-specific serine metabolism differentially controls natural killer cell functions. [PDF]

Nat Metab
Li JH, Feng Q, Ball AB, Lee CD, Wallerius ML, Bormin JG, Kapelczak ED, Armstrong WR, Hermans L, Krall A, Matulionis N, TeSlaa T, Christofk HR, Divakaruni AS, O'Sullivan TE.   +14 more
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Metabolic reprogramming in bone metastasis of human cancers. [PDF]

Front Cell Dev Biol
Li T, Wang Z, Yang H, Kang Y.
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Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer. [PDF]

Front Oncol
Yang L, Li Z, Wang M, Xiong X, Zhang S, Man Z, Dong C, Fu L.   +7 more
europepmc   +1 more source

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Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors

Cellular and Molecular Life Sciences, 2021
The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated promising tumor-suppressing activities. However, the enzyme properties of PHGDH are not well understood and the discovery of PHGDH inhibitors is still in its infancy.
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao, Qingxiang Sun   +8 more
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Abstract 3014: PHGDH- A therapeutic vulnerability in melanoma

Cancer Research, 2022
Abstract Recurrently amplified oncogenes may represent melanoma vulnerabilities that can be exploited for therapy. The genomic locus containing the Phosphoglycerate Dehydrogenase (PHGDH) gene at chromosome 1p12 is frequently amplified in melanoma.
Neel N. Jasani, Florian Karreth
openaire   +1 more source