Results 21 to 30 of about 154,752 (304)

Exploring the potential of AgNPs in modulating the PI3K/AKT/mTOR pathway via miR-133a regulation in MCF-7 breast cancer cells [PDF]

Nanomedicine Journal
Objective(s): Breast cancer is the most common malignancy in women. MiRNAs modulate the PI3K/AKT/mTOR (PAM) pathway, functioning as either tumor suppressors or oncogenes. This research explores the impact of AgNPs on breast cancer cells while emphasizing
Mohammadjavad Hossein Tehrani, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Zeinab Barartabar, Somayeh Aslani   +4 more
doaj   +1 more source

The multifaceted roles of PI3Kγ in hypertension, vascular biology, and inflammation [PDF]

, 2016
PI3Kγ is a multifaceted protein, crucially involved in cardiovascular and immune systems. Several studies described the biological and physiological functions of this enzyme in the regulation of cardiovascular system, while others stressed its role in ...
Carnevale, Daniela, Lembo, Giuseppe, Perrotta, Marialuisa   +2 more
core   +2 more sources

Association of Genetic Variations in The PIK3-AKT-mTOR Pathway with Endometriosis Susceptibility: A Preliminary Case-Control Study [PDF]

International Journal of Fertility and Sterility
Background: Endometriosis is a complex, heterogeneous disease with several genetic and non-genetic pathogenic fac­tors. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway may influence both ...
Rahele Ghasemian Moghadam, Forough Forghani, Danial Jahantigh, Saeedeh Ghazaey Zidanloo, Mahnaz Rezaei, Mohsen Taheri   +5 more
doaj   +1 more source

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Catapano, AL, Chiozzotto, D, Falasca, M, Maffucci, T, Mavrommati, I, Norata, GD, Pineiro, R, Tibolla, G, Wheeler, AP   +8 more
core   +10 more sources

Phosphatidylinositol 3-Kinase Regulates Thymic Exit [PDF]

The Journal of Immunology, 2005
Abstract To understand the role of PI3K during T cell development, we generated transgenic mice expressing the N terminus of the PI3K catalytic subunit (p110ABD; ABD, adaptor binding domain) in thymocytes. Expression of p110ABD activates endogenous p110 and results in the accumulation of mature single-positive CD3highheat-stable Aglow ...
Susannah D, Barbee, Jose, Alberola-Ila
openaire   +2 more sources

The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics

Scientific Reports, 2023
Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabolism ...
Dhanushan Wijayaratna, Kasun Ratnayake, Sithurandi Ubeysinghe, Dinesh Kankanamge, Mithila Tennakoon, Ajith Karunarathne   +5 more
doaj   +1 more source

Editorial: Membrane lipids in T cell functions [PDF]

, 2018
Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core   +1 more source

Phosphatidylinositol 3-Kinase [PDF]

Circulation Research, 2002
The pathogenesis of essential hypertension is multifactorial. Although the cause of elevated arterial pressure is unknown in most cases, the fundamental hemodynamic abnormality in hypertension is increased peripheral resistance primarily due to changes in vascular structure and function.1 These changes include arterial wall thickening and abnormal ...
Masataka, Sata, Ryozo, Nagai
openaire   +2 more sources

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]

, 2020
According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel, Diaconu, Camelia Cristina, Greabu, Maria, Miricescu, Daniela, Rusu, Ioana Ruxandra, Spinu, Dan, Stanescu, Ana Maria Alexandra, Stefani, Constantin, Totan, Alexandra   +8 more
core   +3 more sources

Phosphatidylinositol 3-Kinase: The Oncoprotein [PDF]

, 2010
The catalytic and regulatory subunits of class I phosphoinositide 3-kinase (PI3K) have oncogenic potential. The catalytic subunit p110α and the regulatory subunit p85 undergo cancer-specific gain-of-function mutations that lead to enhanced enzymatic activity, ability to signal constitutively, and oncogenicity.
Peter K, Vogt, Jonathan R, Hart, Marco, Gymnopoulos, Hao, Jiang, Sohye, Kang, Andreas G, Bader, Li, Zhao, Adam, Denley   +7 more
openaire   +2 more sources