Virulence, 2021 PE_PGRS proteins of Mycobacterium tuberculosis (Mtb) constitute a large family of complex modular proteins whose role is still unclear. Among those, we have previously shown, using the heterologous expression in Mycobacterium smegmatis, that PE_PGRS3 ...
Flavio De Maio +12 more
doaj +2 more sources
PLoS ONE, 2021 Quantification of endogenous biomarkers in clinical studies requires careful evaluation of a number of assay performance parameters. Comparisons of absolute values from several clinical studies can enable retrospective analyses further elucidating the ...
Yue Huang +5 more
doaj +2 more sources
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans [PDF]
Journal of Hepatology, 2016 Non peer ...
Arola, Johanna +7 more
core +2 more sources
Cell Communication and Signaling, 2021 Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells.
Smita Eknath Desale +1 more
doaj +2 more sources
The biosynthesis of phosphatidylinositol in human platelets [PDF]
Journal of Clinical Investigation, 1970 Homogenates of human platelets can mediate the synthesis of phosphatidylinositol from myoinositol and cytidine diphosphate diglyceride. The cytidine diphosphate diglyceride: myoinositol, phosphatidyl transferase activity is particulate-bound, and the highest specific activity is found in the membrane fraction.
William J. Williams +2 more
openaire +4 more sources
Resolution of intact phosphatidylinositols by argentation thin-layer chromatography
Journal of Lipid Research, 1971 An argentation thin-layer chromatographic method is described for the separation of intact phosphatidylinositols on the basis of the degree of unsaturation of their component fatty acids.
B.J. Holub, A. Kuksis
doaj +2 more sources
Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates [PDF]
Cell Communication and Signaling, 2006 BACKGROUND: Reversible interactions between the components of cellular signaling pathways allow for the formation and dissociation of multimolecular complexes with spatial and temporal resolution and, thus, are an important means of integrating multiple ...
Buckley, Colin T +2 more
core +5 more sources
Editorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes [PDF]
Frontiers in Pharmacology, 2015 The voltage-sensing phosphatase (VSP) has changed the way we think about both cellular electrical activity and PIPs (phosphatidylinositol phosphates). Originally discovered in 1999 (Chen et al., 1999), these proteins were not recognized as electrically ...
Kohout, Susy C. +1 more
core +6 more sources
The Genetic Background of Abnormalities in Metabolic Pathways of Phosphoinositides and Their Linkage with the Myotubular Myopathies, Neurodegenerative Disorders, and Carcinogenesis. [PDF]
Biomolecules, 2023 Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation ...
Derkaczew M +5 more
europepmc +2 more sources
Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study. [PDF]
PLoS OneThere is a phenotype of obese individuals termed metabolically healthy obese that present a reduced cardiometabolic risk. This phenotype offers a valuable model for investigating the mechanisms connecting obesity and metabolic alterations such as Type 2 ...
Bertran L +5 more
europepmc +2 more sources