Results 21 to 30 of about 77,486 (386)

Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis

ACS Infectious Diseases, 2022
One-fourth of the global human population is estimated to be infected with strains of the Mycobacterium tuberculosis complex (MTBC), the causative agent of tuberculosis (TB). Using lipidomic approaches, we show that tuberculostearic acid (TSA)-containing
Julius Brandenburg, J. Heyckendorf, Franziska Marwitz, Nicole Zehethofer, Lara Linnemann, N. Gisch, H. Karaköse, M. Reimann, K. Kranzer, B. Kalsdorf, Patricia M Sánchez-Carballo, Michael Weinkauf, Verena Scholz, S. Malm, S. Homolka, K. Gaede, C. Herzmann, U. Schaible, Christoph Hölscher, N. Reiling, D. Schwudke   +20 more
semanticscholar   +1 more source

Branched-chain amino acids and specific phosphatidylinositols are plasma metabolite pairs associated with menstrual pain severity. [PDF]

Sci Rep
Menstrual pain affects women’s quality of life and productivity, yet objective molecular markers for its severity have not been established owing to the variability in blood levels and chemical properties of potential markers such as plasma steroid ...
Sato A, Yuyama K, Ichiba Y, Kakizawa Y, Sugiura Y.   +4 more
europepmc   +2 more sources

Identification of Key Phospholipids That Bind and Activate Atypical PKCs

Biomedicines, 2021
PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with ...
Suresh Velnati, Sara Centonze, Federico Girivetto, Daniela Capello, Ricardo M. Biondi, Alessandra Bertoni, Roberto Cantello, Beatrice Ragnoli, Mario Malerba, Andrea Graziani, Gianluca Baldanzi   +10 more
doaj   +1 more source

Oleic Acid-Containing Phosphatidylinositol Is a Blood Biomarker Candidate for SPG28

Biomedicines, 2023
Hereditary spastic paraplegia is a genetic neurological disorder characterized by spasticity of the lower limbs, and spastic paraplegia type 28 is one of its subtypes.
Takuya Morikawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kosei Moriyama, Gohsuke Hattori, Ryuta Fujioka, Shiroh Miura, Hiroki Shibata   +8 more
doaj   +1 more source

Regulation of Necroptosis by Phospholipids and Sphingolipids

Cells, 2020
Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage ...
Xuewei Zhang, Masaya Matsuda, Nobuo Yaegashi, Takeshi Nabe, Kazuyuki Kitatani   +4 more
doaj   +1 more source

Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates

Scientific Reports, 2021
Lipidome-wide metabolites may be useful biomarkers of pregnancy outcomes. We sought to characterize maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters.
Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Vélez-Vega, Akram N. Alshawabkeh, José F. Cordero, John D. Meeker   +8 more
doaj   +1 more source

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index. [PDF]

Metabolites
Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood.
Naja K, Anwardeen N, Albagha O, Elrayess MA.   +3 more
europepmc   +2 more sources

Worms, Fat, and Death: Caenorhabditis elegans Lipid Metabolites Regulate Cell Death

Metabolites, 2021
Caenorhabditis elegans is well-known as the model organism used to elucidate the genetic pathways underlying the first described form of regulated cell death, apoptosis. Since then, C.
Marcos A. Perez, Jennifer L. Watts
doaj   +1 more source

Mechanical properties of anionic asymmetric bilayers from atomistic simulations [PDF]

, 2021
Mechanotransduction, the biological response to mechanical stress, is often initiated by the activation of mechanosensitive (MS) proteins upon mechanically induced deformations of the cell membrane. A current challenge to fully understand this process is to predict how lipid bilayers deform upon application of mechanical stress.
arxiv   +1 more source

Ion Mobility–Mass Spectrometry Approach for the Comparison of Sheep and Goat Milk Lipidomes

Applied Sciences, 2023
In this work, we report an analytical procedure to investigate the lipid compositions of sheep and goat milk. This approach is based on an ion mobility–high-resolution mass spectrometric method to facilitate the identification of complex lipid species ...
Cristina Manis, Paola Scano, Viviana Garau, Margherita Addis, Ignazio Ibba, Pierluigi Caboni   +5 more
doaj   +1 more source