Results 21 to 30 of about 79,046 (379)
BIOSYNTHESIS OF PHOSPHATIDYLINOSITOL [PDF]
Annals of the New York Academy of Sciences, 1970 Interest in our laboratory in the inositol lipids derives from the presence of relatively high amounts of phosphatidylinositol phosphate (PhIP) and phosphatidylinositol diphosphate (PhIPP) in excitable tissue. It was with this relationship in mind that we embarked on a study of biosynthetic pathways of inositol lipids several years ago. A first step in
Agranoff, Bernard W. +2 more
openaire +3 more sources
Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
eLife, 2017 Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.
Alexander M Walter +15 more
doaj +1 more source
Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
, 2009 The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria +2 more
core +1 more source
Ion Mobility–Mass Spectrometry Approach for the Comparison of Sheep and Goat Milk Lipidomes
Applied Sciences, 2023 In this work, we report an analytical procedure to investigate the lipid compositions of sheep and goat milk. This approach is based on an ion mobility–high-resolution mass spectrometric method to facilitate the identification of complex lipid species ...
Cristina Manis +5 more
doaj +1 more source
Mammalian Phosphatidylinositol 4‐Kinases [PDF]
IUBMB Life, 2003 AbstractThree phosphatidylinositol 4‐kinase isoforms, PI4K 230, 92 and 55 have been cloned and sequenced allowing a much wider characterization than the previously employed enzymological typing into type II and III enzymes. PI4K 230 and 92 contain a highly conserved catalytic core, PI4K55 one with a much lower degree of similarity.
Ludwig M G, Heilmeyer +4 more
openaire +2 more sources
The kinetics of folding of the NSH2 domain from p85 [PDF]
, 2019 SH2 domains are protein domains that mediate protein-protein interaction through the recognition and binding of specific sequences containing phosphorylated tyrosines.
Gianni, Stefano +3 more
core +2 more sources
Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]
, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP +3 more
core +1 more source
Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. [PDF]
, 2016 ObjectiveTo determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis
Boyle, David +6 more
core +2 more sources
British Journal of Cancer, 2019 Background The fatty acid (FA) composition of phosphatidylinositols (PIs) is tightly regulated in mammalian tissue since its disruption impairs normal cellular functions.
M. Kawashima +11 more
semanticscholar +1 more source
Antioxidants, 2021 Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C ...
Pan Li +3 more
doaj +1 more source