Results 31 to 40 of about 8,270 (191)
Untersuchungen zur Topologie der Glycosylphosphatidylinositol-Biosynthese in Toxoplasma gondii [PDF]
, 2004 Toxoplasma gondii ist ein obligat intrazellulär lebendes, parasitisches Protozoon mit großer medizinischer Bedeutung vor allem in zwei Fällen: Zum einen bei Erstinfektion während einer Schwangerschaft, hier kann es zur Schädigung des Fötus kommen, zum ...
Kimmel, Jürgen +1 more
core +1 more source
Lipid Polarization during Cytokinesis
Cells, 2022 The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets.
Govind Kunduri +2 more
doaj +1 more source
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer [PDF]
, 2009 Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase ...
Gupta, Piyush +4 more
core +1 more source
Journal of Lipid Research, 1989 A quick and efficient thin-layer chromatographic procedure is described for the separation of phosphatidylinositol-4,5-bisphosphate, phosphatidylinositol-4-monophosphate, phosphatidylinositol, phosphatidylcholine, phosphatidic acid, and ...
J D Medh, P H Weigel
doaj +1 more source
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology [PDF]
, 2019 Introduction: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD.
Arnold, Matthias +10 more
core +2 more sources
Foods, 2022 Rosa roxburghii fruit is an underutilized functional food abundant in polyphenols. Polyphenols have been proved to have antidiabetic effects. This study investigates the effects of Rosa roxburghii fruit polyphenols extract (RPE) on plasma metabolites and
Hui Wang +8 more
doaj +1 more source
Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in vitro and in vivo against several species of Leishmania, the etiological agent of leishmaniasis.
Cristiana T. Trinconi +7 more
doaj +1 more source
Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma. [PDF]
, 2018 Lipidomics - the global assessment of lipids - can be performed using a variety of mass spectrometry (MS)-based approaches. However, choosing the optimal approach in terms of lipid coverage, robustness and throughput can be a challenging task.
Brunet, Anne +6 more
core +3 more sources
Effects of 3D Geometries on Cellular Gradient Sensing and Polarization
, 2016 During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is ...
Andasari, Vivi +4 more
core +1 more source
Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]
, 1994 . Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard +3 more
core +3 more sources