Results 31 to 40 of about 77,486 (386)

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

eLife, 2017
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites.
Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen   +15 more
doaj   +1 more source

The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells. [PDF]

PLoS ONE, 2013
The ether-lipid precursor sn-1-O-hexadecylglycerol (HG) can be used to compensate for early metabolic defects in ether-lipid biosynthesis. To investigate a possible metabolic link between ether-linked phospholipids and the rest of the cellular lipidome ...
Jonas Bergan, Tore Skotland, Tuulia Sylvänne, Helena Simolin, Kim Ekroos, Kirsten Sandvig   +5 more
doaj   +1 more source

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

Antioxidants, 2021
Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C ...
Pan Li, Zehua Wang, Sin Man Lam, Guanghou Shui   +3 more
doaj   +1 more source

High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer

British Journal of Cancer, 2019
Background The fatty acid (FA) composition of phosphatidylinositols (PIs) is tightly regulated in mammalian tissue since its disruption impairs normal cellular functions.
M. Kawashima, M. Tokiwa, T. Nishimura, Yukiko Kawata, M. Sugimoto, T. Kataoka, T. Sakurai, K. Iwaisako, E. Suzuki, M. Hagiwara, A. Harris, M. Toi   +11 more
semanticscholar   +1 more source

T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols

Journal of Biological Chemistry, 2019
T-cell receptor (TCR) signaling strength is a dominant factor regulating T-cell differentiation, thymic development, and cytokine signaling. The molecular mechanisms by which TCR signal strength is transduced to downstream signaling networks remains ill ...
William F. Hawse, R. Cattley
semanticscholar   +1 more source

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

eLife, 2018
Gradients of PtdIns4P between organelle membranes and the endoplasmic reticulum (ER) are thought to drive counter-transport of other lipids via non-vesicular traffic.
James P Zewe, Rachel C Wills, Sahana Sangappa, Brady D Goulden, Gerald RV Hammond   +4 more
doaj   +1 more source

Recognition of polyunsaturated acyl chains by enzymes acting on membrane lipids [PDF]

, 2012
Polyunsaturated acyl chains play an important role in human biology. These lipids cannot be synthesized de novo and they are selectively distributed to certain organs and are found predominantly only in certain lipid classes. Their selective distribution
Epand, Richard M.
core   +1 more source

Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology [PDF]

, 2019
Introduction: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD.
Arnold, Matthias, Baillie, Rebecca, Barupal, Dinesh Kumar, Consortium, Alzheimer Disease Metabolomics, Fan, Sili, Fiehn, Oliver, Initiative, Alzheimer's Disease Neuroimaging, Kaddurah‐Daouk, Rima, Meikle, Peter J, Nho, Kwangsik, Saykin, Andrew J   +10 more
core   +2 more sources

Increased Concentration of Polyvalent Phospholipids in the Adsorption Domain of a Charged Protein [PDF]

Biophys. J. 86, 2165 (2004), 2003
We studied the adsorption of a charged protein onto an oppositely charged membrane, composed of mobile phospholipids of differing valence, using a statistical-thermodynamical approach. A two-block model was employed, one block corresponding to the protein-affected region on the membrane, referred to as the adsorption domain, and the other to the ...
arxiv   +1 more source

Lipidomics of human umbilical cord serum : identification of unique sterol sulfates [PDF]

, 2017
Aim: There are currently limited lipidomics data for human umbilical cord blood. Therefore, the lipidomes of cord sera from six newborns and sera from six nonpregnant females were compared.
Knip, Jan Mikael, Siljander, Heli Tuija Annika, Wood, Paul   +2 more
core   +1 more source