Results 31 to 40 of about 79,046 (379)

Lipidomics of human umbilical cord serum : identification of unique sterol sulfates [PDF]

open access: yes, 2017
Aim: There are currently limited lipidomics data for human umbilical cord blood. Therefore, the lipidomes of cord sera from six newborns and sera from six nonpregnant females were compared.
Knip, Jan Mikael   +2 more
core   +1 more source

T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols

open access: yesJournal of Biological Chemistry, 2019
T-cell receptor (TCR) signaling strength is a dominant factor regulating T-cell differentiation, thymic development, and cytokine signaling. The molecular mechanisms by which TCR signal strength is transduced to downstream signaling networks remains ill ...
William F. Hawse, R. Cattley
semanticscholar   +1 more source

Differential distribution of orthophosphate-32P and glycerol-14C among molecular species of phosphatidylinositols of rat liver in vivo

open access: yesJournal of Lipid Research, 1971
The incorporation of orthophosphate-32P and glycerol-2-14C into the various species of rat liver phosphatidylinositols as a function of time was determined in vivo. 32P was administered intraperitoneally and glycerol-14C was given intravenously.
B.J. HOLUB, A. KUKSIS
doaj   +1 more source

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

open access: yeseLife, 2018
Gradients of PtdIns4P between organelle membranes and the endoplasmic reticulum (ER) are thought to drive counter-transport of other lipids via non-vesicular traffic.
James P Zewe   +4 more
doaj   +1 more source

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer [PDF]

open access: yes, 2009
Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase ...
Gupta, Piyush   +4 more
core   +1 more source

Untersuchungen zur Topologie der Glycosylphosphatidylinositol-Biosynthese in Toxoplasma gondii [PDF]

open access: yes, 2004
Toxoplasma gondii ist ein obligat intrazellulär lebendes, parasitisches Protozoon mit großer medizinischer Bedeutung vor allem in zwei Fällen: Zum einen bei Erstinfektion während einer Schwangerschaft, hier kann es zur Schädigung des Fötus kommen, zum ...
Kimmel, Jürgen   +1 more
core   +1 more source

Lipid Polarization during Cytokinesis

open access: yesCells, 2022
The plasma membrane of eukaryotic cells is composed of a large number of lipid species that are laterally segregated into functional domains as well as asymmetrically distributed between the outer and inner leaflets.
Govind Kunduri   +2 more
doaj   +1 more source

Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma. [PDF]

open access: yes, 2018
Lipidomics - the global assessment of lipids - can be performed using a variety of mass spectrometry (MS)-based approaches. However, choosing the optimal approach in terms of lipid coverage, robustness and throughput can be a challenging task.
Brunet, Anne   +6 more
core   +3 more sources

Separation of phosphatidylinositols and other phospholipids by two-step one-dimensional thin-layer chromatography.

open access: yesJournal of Lipid Research, 1989
A quick and efficient thin-layer chromatographic procedure is described for the separation of phosphatidylinositol-4,5-bisphosphate, phosphatidylinositol-4-monophosphate, phosphatidylinositol, phosphatidylcholine, phosphatidic acid, and ...
J D Medh, P H Weigel
doaj   +1 more source

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

open access: yesFoods, 2022
Rosa roxburghii fruit is an underutilized functional food abundant in polyphenols. Polyphenols have been proved to have antidiabetic effects. This study investigates the effects of Rosa roxburghii fruit polyphenols extract (RPE) on plasma metabolites and
Hui Wang   +8 more
doaj   +1 more source

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