Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair.
Xueqin Huang +11 more
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Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies [PDF]
Haematologica, 2014 The phosphoinositide 3-kinase pathway represents an important anticancer target because it has been implicated in cancer cell growth, survival, and motility. Recent studies show that PI3K may also play a role in the development of resistance to currently
Elias Jabbour +3 more
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Phosphoinositide 3-kinase inhibitors in lymphoma. [PDF]
Curr Opin Oncol, 2014 The phosphoinositide 3-kinase (PI3K) pathway, with downstream targets including Akt and mammalian target of rapamycin, has been implicated in numerous human cancers, including hematologic malignancies and lymphomas. The development and refinement of PI3K inhibitors directed toward this pathway show promising clinical efficacy.
Curran E, Smith SM.
europepmc +4 more sources
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance Mutations in the PI3K pathway are highly prevalent in cancers, and isoform-specific and pan-PI3K inhibitors have entered clinical trials in both solid and hematologic malignancies. The PI3K δ-specific inhibitor idelalisib (in combination with rituximab) was recently approved for the treatment of chronic lymphocytic leukemia ...
Juvekar A +15 more
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Selective phosphoinositide 3-kinase inhibitors and implication in diabetic retinopathy as pharmacological tools [PDF]
Frontiers in PharmacologyPhosphoinositide 3-kinases (PI3Ks) are ubiquitous enzymes, that regulate different cellular functions, most involved in pathogenesis and progression of several oncological diseases.
Carmela Bonaccorso +10 more
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Identification of Novel Thiazolo[5,4-b]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors [PDF]
Molecules, 2020 A series of novel 2-pyridyl, 4-morpholinyl substituted thiazolo[5,4-b]pyridine analogues have been designed and synthesized in this paper. These thiazolo[5,4-b]pyridines were efficiently prepared in seven steps from commercially available substances in ...
Liang Xia +7 more
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Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. [PDF]
PLoS ONE, 2014 Phosphoinositide 3-kinases (PI3Ks) are promising targets for therapeutic development in cancer. The class I PI3K isoform p110α has received considerable attention in oncology because the gene encoding p110α (PIK3CA) is frequently mutated in human cancer.
Sung Su Yea +6 more
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Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. [PDF]
PLoS ONE, 2012 Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers.Our approach was to perform structural modification and optimization based on previously ...
Peng Wu +7 more
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Phosphoinositide 3-kinase inhibitors are effective therapeutic drugs for the treatment of hepatocellular carcinoma? [PDF]
Clinical and Molecular Hepatology, 2020 Jeong Su Park, Soo Han Bae
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Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]
, 2013 PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Catapano, AL +8 more
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