Development of Phosphoinositide-3 Kinase Pathway Inhibitors for Advanced Cancer [PDF]
Current Oncology Reports, 2010 The phosphoinositide-3 kinase (PI3K) pathway plays a critical role in cancer cell growth and survival. PI3K is activated in human cancers by elevated receptor tyrosine kinase activity, RAS mutation, as well as by mutation, amplification, and deletion of genes encoding components of the pathway.
J. Cleary, G. Shapiro
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Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. [PDF]
PLoS ONE, 2012 Development of small-molecule inhibitors targeting phosphoinositide 3-kinase (PI3K) has been an appealing strategy for the treatment of various types of cancers.Our approach was to perform structural modification and optimization based on previously ...
Peng Wu +7 more
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Antithrombotic phosphoinositide 3‐kinase β inhibitors in humans: a ‘shear’ delight! [PDF]
Journal of Thrombosis and Haemostasis, 2012 Jackson SP, Schoenwaelder SM. Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a ‘shear’ delight!J Thromb Haemost 2012; 10: 2123–6.See also Nylander S, Kull B, Bjorkman JA, Ulvinge J-C, Oakes N, Emanuelsson BM, Andersson M, Skarby T, Inghardt T, Fjellstrom O, Gustafsson D.
Shaun P. Jackson, S. Schoenwaelder
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Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors [PDF]
Molecular Cancer Research, 2009 Phosphoinositide 3-kinase (PI3K)/protein kinase B/Akt and Ras/mitogen-activated protein kinase pathways are often constitutively activated in melanoma and have thus been considered as promising drug targets.
Romina Marone +10 more
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Phosphoinositide Signaling and Actin Polymerization Are Critical for Tip Growth in the Marine Red Alga Pyropia yezoensis [PDF]
PlantsIn the marine red alga Pyropia yezoensis, filamentous phases of the life cycle, e.g., the conchocelis (sporophyte) and conchosporangium (conchosporophyte), proliferate by tip growth.
Ryunosuke Irie, Koji Mikami
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Phosphoinositide 3-kinase inhibitors are effective therapeutic drugs for the treatment of hepatocellular carcinoma? [PDF]
Clinical and Molecular Hepatology, 2020 Jeong Su Park, Soo Han Bae
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Vascular malformations: from genetics to therapeutics [PDF]
EMBO Molecular MedicineVascular malformations (VMs) are congenital disorders characterized by structurally abnormal blood and lymphatic vessels. Advances in genetics have revealed that most sporadic VMs result from post-zygotic variants in genes involved in key endothelial ...
Gabriel Morin +2 more
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Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors
Frontiers in Pharmacology, 2022 Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging to the protein kinase A, G, and C (AGC) family. Upon initiation of the phosphoinositide 3-kinase (PI3K) signaling pathway, mammalian target of rapamycin complex 2 ...
Hyunsoo Jang +3 more
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Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Nature Communications, 2023 Generative Deep Learning holds promise for mining the unexplored “chemical universe” for new drugs. Here, the authors demonstrate the de novo design of phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors for the PI3K/Akt pathway in human tumor cells.
Michael Moret +8 more
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An updated review on activated PI3 kinase delta syndrome (APDS)
Genes and Diseases, 2020 Activated Phosphoinositide 3-kinase δ syndrome (APDS) is a newly recognised primary immunodeficiency disease. It has currently been a hot topic of clinical research and new data are emerging regarding its pathogenesis, clinical manifestations and ...
Ankita Singh +4 more
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