Results 31 to 40 of about 425,150 (316)
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization [PDF]
, 2015 Signalling triggered by adhesion to the extracellular matrix plays a key role in the spatial orientation of epithelial polarity and formation of lumens in glandular tissues.
Awad, Aline +10 more
core +1 more source
Phosphoinositide 3-kinase p110γ in immunity [PDF]
IUBMB Life, 2011 The rapid and accurate response of leukocytes to environmental cues is critical for a proper inflammatory reaction to foreign particles or invading microbes. In the last decade, the signal transduction enzyme phosphoinositide 3-kinase γ (PI3Kγ) has emerged as a critical modulator of leukocyte responses, with its effects spanning from recruitment to the
COSTA, Carlotta +2 more
openaire +3 more sources
Frontiers in Pediatrics, 2018 Activated phosphoionositide-3 kinase delta syndrome (APDS) is a rare disorder caused by activating mutations in phosphoionositide 3-kinase delta (PI3Kδ).
Michele N. Pham +2 more
doaj +1 more source
PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
Clinical and Translational Medicine, 2020 Background Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivity in chronic airway diseases ...
Jing Bi +10 more
doaj +1 more source
Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]
, 2018 The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk +2 more
core +2 more sources
Circulation, 2018 Background: Anthracyclines, such as doxorubicin (DOX), are potent anticancer agents for the treatment of solid tumors and hematologic malignancies. However, their clinical use is hampered by cardiotoxicity.
Mingchuan Li +32 more
semanticscholar +1 more source
Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE)
The Scientific World Journal, 2010 GTP-binding proteins are the molecular switches of numerous cellular functions, including migration, proliferation, and differentiation. In the past 10 years, we have characterized a novel class of GTPases called phosphoinositide-3 kinase enhancer (PIKE)
Chi Bun Chan, Keqiang Ye
doaj +1 more source
Tumor Biology, 2017 In this study, we investigated the underlying mechanism of the phosphoinositide 3-kinase/Akt– and Wnt/β-catenin-mediated promotion of epithelial-to-mesenchymal transition by epigenetic regulation of histone acetylation in gastric cancer.
Yue Song +5 more
doaj +1 more source
3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib
Communications Biology, 2023 Osimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate potential resistance mechanisms.
Ismail M. Meraz +20 more
doaj +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources