Results 1 to 10 of about 2,910 (123)

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization [PDF]

Biomolecules, 2023
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase.
Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno   +11 more
doaj   +5 more sources

Prognostic microRNAs associated with phosphoserine aminotransferase 1 in gastric cancer as markers of bone metastasis [PDF]

Frontiers in Genetics, 2022
This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The relationship between the clinical manifestations of gastric cancer in patients and phosphoserine aminotransferase 1 (PSAT1) was analyzed using correlation ...
Jingwei Ma, Meng Zhu, Xiaofeng Ye, Bo Wu, Tao Wang, Muyuan Ma, Tao Li, Ning Zhang   +7 more
doaj   +4 more sources

Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship [PDF]

BMC Research Notes, 2010
Background Presence of phosphorylated Serine biosynthesis pathway upstream to the de novo cysteine biosynthesis pathway makes PSAT a crucial enzyme. Besides this, phoshoserine produced by the enzyme can also be taken up directly by cysteine synthase as a
Bhakuni Vinod, Nozaki Tomoyoshi, Ali Vahab, Mishra Vibhor   +3 more
doaj   +5 more sources

Overexpression of Phosphoserine Aminotransferase (PSAT)-Enhanced Cadmium Resistance and Accumulation in Duckweed (Lemna turionifera 5511) [PDF]

Plants
Cadmium (Cd) hampers plant growth and harms photosynthesis. Glutamate (Glu) responds to Cd stress and activates the Ca2+ signaling pathway in duckweed, emphasizing Glu’s significant role in Cd stress.
Xu Ma, Yumeng Jiang, Ziyang Qu, Yunwen Yang, Wenqiao Wang, Yuman He, Yiqi Yu, Ximeng Luo, Yuanyuan Liu, Wenqian Han, Qiqi Di, Lin Yang, Yong Wang   +12 more
doaj   +4 more sources

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

Scientific Reports, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Tommaso De Marchi, Mieke A. Timmermans, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, Nicolai Grebenchtchikov, Fred C. G. J. Sweep, Jan G. Smits, Viktor Magdolen, Carolien H. M. van Deurzen, John A. Foekens, Arzu Umar, John W. Martens   +12 more
doaj   +8 more sources

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells [PDF]

Molecular Cancer, 2008
Background Colorectal cancer (CRC) is one of the most common causes of cancer death throughout the world. In this work our aim was to study the role of the phosphoserine aminotransferase PSAT1 in colorectal cancer development.
Conseiller Emmanuel, Fraslon Caroline, Robert Bruno, Bec Nicole, Denis Vincent, Bascoul-Mollevi Caroline, Copois Virginie, Vié Nadia, Molina Franck, Larroque Christian, Martineau Pierre, Del Rio Maguy, Gongora Céline   +12 more
doaj   +5 more sources

Molecular Structure of Phosphoserine Aminotransferase from Saccharomyces cerevisiae. [PDF]

Int J Mol Sci, 2023
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate-dependent enzyme involved in the second step of the phosphorylated pathway of serine biosynthesis. PSAT catalyzes the transamination of 3-phosphohydroxypyruvate to 3-phosphoserine using L-glutamate as the amino donor.
Jang J, Chang JH.
europepmc   +3 more sources

The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia-reperfusion injury. [PDF]

J Cell Commun Signal, 2023
Hepatic ischemia-reperfusion (I/R) injury is a severe clinical syndrome, causing a profound medical and socioeconomic burden worldwide. This study aimed to explore underlying biomarkers and treatment targets in the progression of hepatic I/R injury. We screened gene expression profiles of the hepatic I/R injury from the Gene Expression Omnibus (GEO ...
Deng Y, Luo H.
europepmc   +3 more sources

L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase. [PDF]

Protein Sci, 2023
AbstractOrganisms from all kingdoms of life synthesize L‐serine (L‐Ser) from 3‐phosphoglycerate through the phosphorylated pathway, a three‐step diversion of glycolysis. Phosphoserine aminotransferase (PSAT) catalyzes the intermediate step, the pyridoxal 5′‐phosphate‐dependent transamination of 3‐phosphohydroxypyruvate and L‐glutamate to O ...
Marchesani F, Zangelmi E, Murtas G, Costanzi E, Ullah R, Peracchi A, Bruno S, Pollegioni L, Mozzarelli A, Storici P, Campanini B.   +10 more
europepmc   +6 more sources

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis [PDF]

Frontiers in Plant Science, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula, Milosz Ruszkowski, Zbigniew Dauter   +2 more
doaj   +2 more sources