Results 21 to 30 of about 2,949 (161)

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

Endocrine Regulations, 2023
Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells

环境与职业医学, 2022
BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI, Jinmei HAN, Hongqian HUANG, Na WANG, Aihua ZHANG, Xue HAN   +5 more
doaj   +1 more source

Phosphoserine Aminotransferase in Soybean Root Nodules [PDF]

Plant Physiology, 1986
Phosphoserine aminotransferase activity was detected in the plant and bacteroid fractions from soybean (Glycine max) root nodules. Both total and specific activities increased in the plant fraction during nodule development. Serine-pyruvate aminotransferase activity was not detectable in the plant or bacteroid fractions of these nodules.
P H, Reynolds, D G, Blevins
openaire   +2 more sources

[179] Phosphoserine aminotransferase (sheep brain)

Archives of Biochemistry and Biophysics, 1971
Publisher Summary This chapter focuses on Phosphoserine Aminotransferase (Sheep Brain). The chapter begins with a discussion of Assay method. Phosphohydroxypyruvate is prepared by hydrolysis of the hydroxypyruvic acid phosphate dimethylketal according to the procedure of Ballou.
Helga Hirsch-Kolb, David M. Greenberg
  +7 more sources

Phosphoserine Aminotransferase, the Second Step-Catalyzing Enzyme for Serine Biosynthesis [PDF]

IUBMB: Life, 1999
AbstractAs a step toward analyzing the serine biosynthetic pathway in mammals, we have studied the properties of phosphoserine aminotransferase, the second step‐catalyzing enzyme. The Km values for 3‐phosphohydroxypyruvate and L‐phosphoserine are 5 and 35 mu M, respectively, and those for glutamate and alpha‐ketoglutarate are 1.2 and 0.8 mM ...
M J, Basurko, M, Marche, M, Darriet, A, Cassaigne   +3 more
openaire   +2 more sources

A phosphoserine phosphatase variant present in the brain of Alzheimer's disease patients favors nuclear mistargeting. [PDF]

FEBS J
l‐serine levels in the human brain are maintained by the phosphorylated pathway, a three‐step process catalyzed by phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase (PSP). These enzymes assemble in a metabolon called the serinosome. The double R27S/D32G PSP variant was identified in the brain of
Sacchi S, Buoli Comani V, Arisi I, Marchesani F, Rabattoni V, De Bei O, Motta Z, Peracchi A, Bruno S, Pollegioni L, Campanini B.   +10 more
europepmc   +2 more sources

Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion

Frontiers in Plant Science, 2018
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
doaj   +1 more source

Targeting the Serine Pathway: A Promising Approach against Tuberculosis?

Pharmaceuticals, 2019
Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging.
Marie Haufroid, Johan Wouters
doaj   +1 more source

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Shuxuan Zhu, Xiaoyu Wang, Lei Liu, Guosheng Ren   +3 more
doaj   +1 more source

Studies on Phosphoserine Aminotransferase of Sheep Brain

Journal of Biological Chemistry, 1967
Abstract Phosphoserine aminotransferase has been purified about 500-fold from sheep brain extracts by ammonium sulfate precipitation and Sephadex and diethylaminoethyl cellulose chromatography. On ultracentrifugation, the enzyme migrated in a single peak with a sedimentation constant of 4.2 S.
H, Hirsch, D M, Greenberg
openaire   +2 more sources