Results 41 to 50 of about 2,949 (161)

Post‐translational regulation of human D‐3‐phosphoglycerate dehydrogenase in Alzheimer's disease

Protein Science, Volume 35, Issue 3, March 2026.
Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Elena Zerbini, Daniele Riva, Elisa Maffioli, Gabriella Tedeschi, Silvia Sacchi, Loredano Pollegioni   +5 more
wiley   +1 more source

Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome

Frontiers in Molecular Biosciences, 2021
Background: Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder associated with premutation CGG-repeat expansions (55–200 repeats) in the 5′ non-coding portion of the fragile X mental retardation 1 (FMR1) gene.
Katharine Nichole Holm, Anthony W. Herren, Sandra L. Taylor, Jamie L. Randol, Kyoungmi Kim, Kyoungmi Kim, Glenda Espinal, Verónica Martínez-Cerdeño, Verónica Martínez-Cerdeño, Isaac N. Pessah, Isaac N. Pessah, Randi J. Hagerman, Randi J. Hagerman, Paul J. Hagerman, Paul J. Hagerman   +14 more
doaj   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, Volume 9, Issue 1, Page 115-127, January 2026.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma

Cellular Physiology and Biochemistry, 2016
Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu, Yiping Jia, Yan Cao, Shaoqiu Wu, Haosheng Jiang, Xianjun Sun, Jun Ma, Xiang Yin, Aiwu Mao, Mingyi Shang   +9 more
doaj   +1 more source

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3‐dependent PDGFB signaling

Cancer Communications, Volume 45, Issue 12, Page 1706-1733, December 2025.
Abstract Background Metastasis is the leading cause of cancer‐related mortality, with circulating tumor cell (CTC) clusters serving as highly efficient precursors of distant metastasis. Survival of CTC clusters in the bloodstream is the primary contributor to tumor metastasis.
Rui Tang, Yan Sun, Ao Deng, Jiahe Liu, Peijin Dai, Jing Chen, Chaoqun Deng, Hui Liu, Yuhang Hai, Yanran Tong, Yan‐e Du, Manran Liu, Haojun Luo   +12 more
wiley   +1 more source

Hydrocortisone interacts with endoplasmic reticulum stress in hypoxic regulation of phosphoserine aminotransferase 1 gene expression differently in normal human astrocytes and glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum (ER) stress and hypoxia are key factors for the effective growth of malignant tumors, including glioblastoma. The phosphoserine aminotransferase 1 (PSAT1) is an ER stress-responsive enzyme responsible for serine synthesis
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khikhlo Yevgen P., Sliusar Myroslava Y., Halkin Oleh V., Luzina Olha Y., Danilovsryi Serhiy V., Viletska Yuliia M., Minchenko Dmytro O.   +8 more
doaj   +1 more source

Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

BMC Evolutionary Biology, 2017
Background An important feature of eukaryotic evolution is metabolic compartmentalization, in which certain pathways are restricted to the cytosol or specific organelles. Glycolysis in eukaryotes is described as a cytosolic process.
Melania Abrahamian, Meenakshi Kagda, Audrey M. V. Ah-Fong, Howard S. Judelson   +3 more
doaj   +1 more source

An integrated pan-cancer analysis of PSAT1: A potential biomarker for survival and immunotherapy

Frontiers in Genetics, 2022
Phosphoserine aminotransferase 1 (PSAT1) may be an oncogene that plays an important role in various cancer types. However, there are still many gaps in the expression of PSAT1 gene and its biological impact in different types of tumors.
Mingtao Feng, Huanhuan Cui, Wenjing Tu, Liangdong Li, Yang Gao, Lei Chen, Deheng Li, Xin Chen, Fengfeng Xu, Changshuai Zhou, Yiqun Cao   +10 more
doaj   +1 more source

High serine:glyoxylate aminotransferase activity lowers leaf daytime serine levels, inducing the phosphoserine pathway in Arabidopsis [PDF]

Journal of Experimental Botany, 2016
Serine:glyoxylate aminotransferase (SGAT) converts glyoxylate and serine to glycine and hydroxypyruvate during photorespiration. Besides this, SGAT operates with several other substrates including asparagine. The impact of this enzymatic promiscuity on plant metabolism, particularly photorespiration and serine biosynthesis, is poorly understood.
Modde, K., Timm, S., Florian, A., Michl, K., Fernie, A., Bauwe, a.   +5 more
openaire   +3 more sources