Results 51 to 60 of about 2,949 (161)
In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins
ChemBioChem, Volume 26, Issue 22, November 17, 2025.This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Jan Hendrik Illies +2 more
wiley +1 more source
Nitrogen Scavengers: History, Clinical Considerations and Future Prospects
Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.ABSTRACT Nitrogen scavengers play a critical role in treating acute and chronic hyperammonemia, especially in urea cycle disorders (UCDs), where impaired ammonia detoxification leads to toxic nitrogen accumulation. These agents complement low‐protein diets and urea cycle intermediates.
Sven Klassa, Johannes Häberle
wiley +1 more source
Marine Drugs, 2019 The acceleration of the process of understanding the pharmacological application of new marine bioactive compounds requires identifying the compound protein targets leading the molecular mechanisms in a living cell.
Ana Carrasco del Amor +4 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Purpose: Current evidence suggests that phosphoserine aminotransferase 1 (PSAT1) is overexpressed in various tumors. Herein, we investigate the significance of PSAT1 in non-small cell lung cancer (NSCLC) and its correlation with immune infiltration ...
Hongmu Li +8 more
doaj +1 more source
Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.Dietary supplementation with fish oil calcium salt improved laying performance, yolk fatty acid profile and egg quality traits during the peak production period. Higher inclusion levels significantly increased n‐3 PUFA content without negative effects on bird health, while moderate levels (0.75%) optimized performance and productivity.
Hamze Ghaderi‐Chaparabad +4 more
wiley +1 more source
Scientific Reports, 2020 Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells. We
Madelaine C. Brearley +4 more
doaj +1 more source
Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2436-2450, November 2025.Using a free‐choice ethanol model, we show that mice switched from a high‐sugar/butter diet to AIN93G standard diet consume and prefer more alcohol than mice maintained on AIN93G. 16S profiling and inferred metabolome revealed reduced amino acid metabolism, increased secondary bile acid pathways, and lower microbiota‐derived SCFAs and selected amino ...
Mírian Velten Mendes +7 more
wiley +1 more source
Biochemistry and Biophysics Reports, 2019 Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is ...
Madelaine C. Brearley +5 more
doaj +1 more source
Scientific Reports, 2023 Phosphoserine aminotransferase 1 (PSAT1) has been associated with the occurrence and development of various carcinomas; however, its function in uterine corpus endometrial carcinoma (UCEC) is unknown.
Min Wang, Song Yue, Zhu Yang
doaj +1 more source
Crystallization and preliminary X‐ray analysis of phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus [PDF]
Protein Science, 1996 AbstractRecombinant phosphoserine aminotransferase (EC 2.6.1.52) from Bacillus circulans subsp. alkalophilus was crystallized at room temperature from 0.1 M sodium acetate buffer, pH 4.6, and 2% PEG 20000, using macroseeding techniques. The crystals diffract X‐rays to at least 2.0 Å nominal resolution.
M, Moser +5 more
openaire +2 more sources