Results 61 to 70 of about 2,949 (161)

Evolutionary and functional relationships between plant and microbial C1 metabolism in terrestrial ecosystems

New Phytologist, Volume 248, Issue 3, Page 1132-1153, November 2025.
Summary One‐carbon (C1) metabolism, centered on the universal methyl donor S‐adenosyl methionine (SAM), plays critical roles in biosynthesis, redox regulation, and stress responses across plants and microbes. A recently proposed photosynthetic C1 pathway links SAM methyl groups directly to RuBisCO‐mediated CO2 assimilation and integrates with nitrogen ...
Kolby J. Jardine, Linnea K. Honeker, Zhaoxin Zhang, Steve Kwatcho Kengdo, Yuguo Yang, Joseph Roscioli, William J. Riley   +6 more
wiley   +1 more source

Investigation Of Phosphoserine Aminotransferase 1 And Its Role In Breast Cancer Progression

The FASEB Journal, 2018
Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival. Metastasis is known to be responsible for 90% of cancer related deaths, and is especially prevalent in triple negative breast cancer (TNBC); while endocrine resistance can ...
Brian Clem, Stephanie Metcalf, Traci Kruer, Carolyn Klinge   +3 more
openaire   +1 more source

Seizures and electroencephalographic findings in inborn errors of metabolism: Clues to differential diagnosis in the neonatal period, infancy, childhood and adolescence, and review of the literature

Epileptic Disorders, Volume 27, Issue 5, Page 745-802, October 2025.
Abstract Although inborn errors of metabolism (IEM) are a rare cause of epilepsy, seizures are a common presentation in these disorders. Seizures in IEM are frequently refractory to conventional anti‐seizure medication and might warrant initiation of specific treatments based on vitamins or dietary modifications or provision of alternative substrates ...
D. Kapoor, S. Sharma, A. Kaminska, R. Nabbout, N. Chemaly, M. Schiff, P. De Lonlay, M. Eisermann   +7 more
wiley   +1 more source

Nf1 loss promotes Kras‐driven lung adenocarcinoma and results in Psat1‐mediated glutamate dependence

EMBO Molecular Medicine, 2019
Mutations to KRAS are recurrent in lung adenocarcinomas (LUAD) and are daunting to treat due to the difficulties in KRAS oncoprotein inhibition. A possible resolution to this problem may lie with co‐mutations to other genes that also occur in KRAS‐driven
Xiaojing Wang, Shengping Min, Hongli Liu, Nan Wu, Xincheng Liu, Tao Wang, Wei Li, Yuanbing Shen, Hongtao Wang, Zhongqing Qian, Huanbai Xu, Chengling Zhao, Yuqing Chen   +12 more
doaj   +1 more source

Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study

Epilepsia, Volume 66, Issue 10, Page 3769-3784, October 2025.
Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen, Annelii Ny, Daniëlle Copmans, Jana Tits, Kenichi Kamata, Eva Gielis, Kevin Longin, Jo Sourbron, Peravina Thergarajan, Tracie Huey‐Lin Tan, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mastura Monif, Bridgette D. Semple, Christine Germeys, Benedetta Frizzi, Virginia Minniti, Sebastian Perrone, Carole L. Linster, Ilaria Elia, Ludo Van Den Bosch, Bruno P. A. Cammue, Arnout Voet, Lieven Lagae, Peter de Witte   +25 more
wiley   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

Engineering and finetuning expression of SerC for balanced metabolic flux in vitamin B6 production

Synthetic and Systems Biotechnology
Vitamin B6 plays a crucial role in cellular metabolism and stress response, making it an essential component for growth in all known organisms. However, achieving efficient biosynthesis of vitamin B6 faces the challenge of maintaining a balanced ...
Kai Chen, Linxia Liu, Jinlong Li, Zhizhong Tian, Hongxing Jin, Dawei Zhang   +5 more
doaj   +1 more source

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background Cancer metabolism is a field focused on the unique alterations in metabolic pathways that occur in cancer cells, distinguishing them from the metabolic processes in normal cells. Methods An extensive review of the current literature on the metabolic adaptation of cancer cells was carried out in the current study. Results The rapidly
Jilsy M. J. Punnasseril, Abdul Auwal, Vinod Gopalan, Alfred King‐Yin Lam, Farhadul Islam   +4 more
wiley   +1 more source

Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance

MedComm, Volume 6, Issue 9, September 2025.
Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu, Weijie Yan, Lingfeng Tong, Jie Yang, Shengfang Ge, Jiayan Fan, Renbing Jia, Xuyang Wen   +7 more
wiley   +1 more source

Comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells.

PLoS ONE, 2013
Classical tooth development theory suggests that dental papilla cells (DPCs) are the precursor cells of odontoblasts, which are responsible for dentin development.
Lijuan Guo, Jie Li, Xiangchen Qiao, Mei Yu, Wei Tang, Hang Wang, Weihua Guo, Weidong Tian   +7 more
doaj   +1 more source