Results 71 to 80 of about 32,053 (206)
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, Volume 2, Issue 1, Page 106-129, March 2026.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Virion structure and genome delivery mechanism of sacbrood honeybee virus [PDF]
, 2018 Infection by sacbrood virus (SBV) from the family Iflaviridae is lethal to honey bee larvae but only rarely causes the collapse of honey bee colonies. Despite the negative effect of SBV on honey bees, the structure of its particles and mechanism of its ...
Füzik, Tibor +6 more
core +1 more source
VirusesBoth hepatitis B virus (HBV), an hepadnavirus with a DNA genome, and hepatitis A virus (HAV), a picornavirus, require the TRAMP-like host ZCCHC14-TENT4 complex for efficient replication.
You Li +9 more
doaj +1 more source
Pathogens, 2020 The diseases with watery droppings (diarrhea and/or polyuria) can be considered some of the most severe health problems in domestic pigeons of various ages.
Ewa Łukaszuk, Tomasz Stenzel
doaj +1 more source
Picornavirus RNA Recombination Counteracts Error Catastrophe [PDF]
Journal of Virology, 2019 Positive-strand RNA viruses produce vast amounts of progeny in very short periods of time via template-dependent RNA replication mechanisms. Template-dependent RNA replication, while efficient, can be disadvantageous due to error-prone viral polymerases. The accumulation of mutations in viral RNA genomes leads to error catastrophe.
Brian J, Kempf +3 more
openaire +2 more sources
Virus‐Dependent Geographic Structure of Co‐Circulating Viruses in a Single Bat Species
Molecular Ecology, Volume 35, Issue 5, March 2026.ABSTRACT Understanding the spatial spread of viruses within wildlife populations is often a key component of disease management efforts. Viral spread is likely constrained by host ecology, but inter‐virus differences in infection strategy might allow some viruses to overcome these constraints, leading to divergent population structures within a common ...
Avery L. Holmes +8 more
wiley +1 more source
Picornavirus 2C proteins: structure-function relationships and interactions with host factors
Frontiers in Cellular and Infection MicrobiologyPicornaviruses, which are positive-stranded, non-enveloped RNA viruses, are known to infect people and animals with a broad spectrum of diseases. Among the nonstructural proteins in picornaviruses, 2C proteins are highly conserved and exhibit multiple ...
Chunhui Yin +14 more
doaj +1 more source
Viruses, 2020 Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive.
Ian Hewson +2 more
doaj +1 more source
Current Protocols, Volume 6, Issue 2, February 2026.Abstract Elevated arterial pressure is a key contributor to cardiovascular disease, yet experimental models that isolate the effects of pressure from confounding systemic factors remain limited. We describe a reproducible surgical protocol to induce mid‐thoracic aortic coarctation in mice, generating a stable and quantifiable arterial pressure gradient
D. Adam Lauver +6 more
wiley +1 more source
Translation of viral mRNA without active eIF2: The case of picornaviruses [PDF]
, 2016 Previous work by several laboratories has established that translation of picornavirus RNA requires active eIF2α for translation in cell free systems or after transfection in culture cells.
Carrasco Llamas, Luis +3 more
core +1 more source