Results 11 to 20 of about 46,002 (241)

Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines

Journal of the American Chemical Society, 2021
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally ...
Vanessa Harawa, T. Thorpe, J. Marshall, Jack J. Sangster, A. Gilio, L. Pirvu, Rachel S. Heath, Antonio Angelastro, J. Finnigan, S. Charnock, Jordan W Nafie, G. Grogan, R. Whitehead, N. Turner   +13 more
semanticscholar   +1 more source

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +1 more source

Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents

Molecules, 2022
The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives of ciprofloxacin using commercially available 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4 ...
Alexei Lukin, Mikhail Chudinov, Tatiana Vedekhina, Elizaveta Rogacheva, Lyudmila Kraeva, Olga Bakulina, Mikhail Krasavin   +6 more
doaj   +1 more source

Highly Diastereoselective Functionalization of Piperidines by Photoredox Catalyzed α-Amino C-H Arylation and Epimerization.

Journal of the American Chemical Society, 2020
We report a photoredox catalyzed α-amino C-H arylation reaction of highly substituted piperidine derivatives with electron deficient cyano(hetero)arenes.
Morgan M. Walker, Brian Koronkiewicz, Shuming Chen, K. N. Houk, J. M. Mayer, J. Ellman   +5 more
semanticscholar   +1 more source

Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation

ACS Catalysis, 2020
Fluorinated piperidines are desirable motifs for pharmaceutical and agrochemical research. Nevertheless, general synthetic access remains out of reach.
Tobias Wagener, A. Heusler, Zackaria Nairoukh, K. Bergander, C. Daniliuc, F. Glorius   +5 more
semanticscholar   +1 more source

Crystal structure of a tetranuclear CuII complex with an O,N,N′-donor Schiff base ligand: hexa-μ2-acetato-bis(2-{[(2,2,6,6-tetramethylpiperidin-4-yl)imino]methyl}phenolato-κ3O,N,N′)tetracopper(II)

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compound, [Cu4(CH3COO)6(C16H23N2O)2], lies across a twofold rotation axis. The asymmetric unit contains two independent CuII ions. The symmetry-unique terminal CuII ion is O,N,N′-coordinated by a 2-{[(2,2,6,6-tetramethylpiperidin-4-yl)imino ...
Guohui Huang, Xiaoxuan Liu
doaj   +1 more source

The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines.

Organic and biomolecular chemistry, 2020
Intramolecular endo-aza-Michael additions are categorised in various ways. Firstly whether they are single or double reactions, secondly whether they are endo- or exo-activated (or both), thirdly whether the Michael acceptor is an alkene or an alkyne ...
R. Bates, Weiting Ko, Viktor Barát
semanticscholar   +1 more source

Scope and Limitations of γ-Valerolactone (GVL) as a Green Solvent to be Used with Base for Fmoc Removal in Solid Phase Peptide Synthesis

Molecules, 2019
GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group.
Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio   +3 more
doaj   +1 more source

Epidemiological Study of Multidrug Resistant and Efficiency of Piperidine Compounds against Hospital Acquired Opportunistic Pathogens in Tamil Nadu, India

Journal of Pure and Applied Microbiology, 2020
The pathogens attained through nosocomial infection exhibit a higher degree of antibiotic resistance due to constant exposure to drug therapy. There is a need to develop alternate therapeutics for treating these resistant pathogens.
Rajendran Venkatasubramani, Thirumoorthy Viswanathan   +1 more
doaj   +1 more source

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts

Frontiers in Chemistry, 2019
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate ...
Alaa Zidan, Alaa Zidan, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Ali Khalil Ali, Laurent El Kaïm   +5 more
doaj   +1 more source