Results 11 to 20 of about 24,519 (327)

Search for Antiviral Preparations in Series of New Derivatives of N-Substituted Piperidines [PDF]

Molecules
Cyanohydrin synthesis, as the simplest preparative method for introducing a carboxyl group into a piperidine molecule, has been used to obtain potentially biologically active piperidinecarboxylic acids, which have alkyl and arylalkyl radicals at the ...
Gulmira S. Akhmetova, Ulzhalgas B. Issayeva, Kaldybay D. Praliyev, Ilya S. Korotetskiy, Tulegen M. Seilkhanov, Samir A. Ross, Manas T. Omyrzakov, Ubaidilla M. Datkhayev, Khaidar S. Tassibekov, Lyudmila N. Ivanova, Natalya V. Zubenko   +10 more
doaj   +2 more sources

N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study

Future Journal of Pharmaceutical Sciences, 2018
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described.
Khairia M. Youssef, Iten M. Fawzy, Hussein I. El-Subbagh   +2 more
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Facile and Practical Synthesis of Substituted Piperidine‐2,6‐Diones Under Transition‐Metal Free Condition [PDF]

ChemistryOpen
Yuehua Liu, Zhang‐Qin Xue, Kaiwen Yang, Hao‐Wen Yin, Bo Yang, Rui Zhang, Hao Zhong, Zhushuang Bai   +7 more
openalex   +2 more sources

Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022
Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova, Aida Seitaliyeva, Elmira Satbayeva, Daniya Serdalieva, Talgat Nurgozhin   +4 more
doaj   +1 more source

CeO2/CuO@N-GQDs@NH2 nanocomposite as a reusable and efficient catalyst for the synthesis of piperidines [PDF]

Nanochemistry Research, 2020
An efficient pseudo six-component synthesis of bis-spiropiperidinesis presented by one-pot condensation of formaldehyde, aromatic amine and dimedone or N,N-dimethyl-barbituric acid using CeO2/CuO@N-GQDs@NH2 nanocomposite at room temperature. The catalyst
Hossein Shahbazi-Alavi, Javad Safaei-Ghomi, Mozhgan Esfandiari   +2 more
doaj   +1 more source

Synthesis and Characterization of Novel Methyl (3)5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates

Molecules, 2021
Series of methyl 3- and 5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates were developed and regioselectively synthesized as novel heterocyclic amino acids in their N-Boc protected ester form for achiral and chiral building blocks.
Gita Matulevičiūtė, Eglė Arbačiauskienė, Neringa Kleizienė, Vilija Kederienė, Greta Ragaitė, Miglė Dagilienė, Aurimas Bieliauskas, Vaida Milišiūnaitė, Frank A. Sløk, Algirdas Šačkus   +9 more
doaj   +1 more source

Designing chemical systems for precision deuteration of medicinal building blocks [PDF]

Nature Communications
Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use.
Jonathan D. Dabbs, Caleb C. Taylor, Martin S. Holdren, Sarah E. Brewster, Brian T. Quillin, Alvin Q. Meng, Diane A. Dickie, Brooks H. Pate, W. Dean Harman   +8 more
doaj   +2 more sources

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +1 more source

Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents

Molecules, 2022
The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives of ciprofloxacin using commercially available 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4 ...
Alexei Lukin, Mikhail Chudinov, Tatiana Vedekhina, Elizaveta Rogacheva, Lyudmila Kraeva, Olga Bakulina, Mikhail Krasavin   +6 more
doaj   +1 more source

Crystal structure of a tetranuclear CuII complex with an O,N,N′-donor Schiff base ligand: hexa-μ2-acetato-bis(2-{[(2,2,6,6-tetramethylpiperidin-4-yl)imino]methyl}phenolato-κ3O,N,N′)tetracopper(II)

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compound, [Cu4(CH3COO)6(C16H23N2O)2], lies across a twofold rotation axis. The asymmetric unit contains two independent CuII ions. The symmetry-unique terminal CuII ion is O,N,N′-coordinated by a 2-{[(2,2,6,6-tetramethylpiperidin-4-yl)imino ...
Guohui Huang, Xiaoxuan Liu
doaj   +1 more source