Results 171 to 180 of about 519,516 (301)

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

A High-Fiber Plant-Based Diet in Myeloma Precursor Disorders - Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model. [PDF]

Cancer Discov
Shah UA, Cogrossi LL, Garces JJ, Policastro A, Castro F, Derkach A, Fei T, DeWolf S, Grioni M, Sisti S, Blaslov J, Adintori PA, Hosszu KK, McAvoy D, Baichoo M, Cross JR, Paredes J, Anuraj A, Raj SS, Pohl C, Zordan P, Zinsmeyer V, Jesus Faustino Ramos RJ, Lorenzoni M, Gipson B, Maclachlan KH, Gradissimo A, Boiocchi L, Aleynick N, Marchigiani C, Pagani S, Salehi E, Koche RP, Chaligne R, Block T, Korde N, Tan CR, Hultcrantz M, Hassoun H, Shah GL, Scordo M, Lahoud OB, Chung DJ, Landau HJ, Peled JU, Clementi N, Chesi M, Bergsagel PL, Mailankody S, Pollak MN, D'Souza A, Landgren O, Chimonas S, Giralt SA, Usmani SZ, Iyengar NM, Lesokhin AM, van den Brink MRM, Bellone M.   +58 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Association of sleep and plant-based diet with cognitive function in older adults-Based on a national cohort study. [PDF]

Asia Pac J Clin Nutr
Bian L, Chen X, Li X.
europepmc   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Comparative analysis of dietary intake between vegetarian and omnivorous strength training practitioners: Protein consumption disparity

Revista Brasileira de Nutrição Esportiva
The interaction between a vegetarian diet and strength training remains an area lacking substantial information. However, it is recognized that both vegetarian and omnivorous practitioners require adequate energy and nutrient intake to optimize ...
Randerson André Fernandes de Souza, João Gabriel Costa Sanches, Fernanda de Souza Teixeira, Peterson Adriano Freire Freire, Wilson César de Abreu   +4 more
doaj  

Plant-based diet and mortality in adults with cardiovascular-kidney-metabolic syndrome: evidence from NHANES with mediation by leukocyte telomere length. [PDF]

Ren Fail
Xiao Z, Chen F, Yin Y, You B, Wang Y, Sun B.   +5 more
europepmc   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Long-term Air Pollution Exposure, Plant-based Diet and Asthma Exacerbations in the Nurses' Health Study II. [PDF]

Ann Am Thorac Soc
Wang JG, Li W, Liu B, Varraso R, Wharton R, Ponce J, Hart JE, Camargo CA, Hanson C, Bose S.   +9 more
europepmc   +1 more source