Results 241 to 250 of about 519,516 (301)

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Interaction of genetic risk score (GRS) and Plant-Based diet on atherogenic factors and body fat distribution indices among women with overweight and obesity: a cross-sectional study. [PDF]

Sci Rep
Hajmir MM, Mirzababaei A, Abaj F, Aali Y, Samadi M, Mirzaei K.   +5 more
europepmc   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Plant-Based Diet Indices with Greenhouse Gas Emissions and Risk of Cardiometabolic Diseases and All-Cause Mortality: Longitudinal China Cohort Study. [PDF]

Nutrients
Lv Y, Wu M, Liu W, Liu K, Wang Y, Cui Z, Ma Q, Meng H.   +7 more
europepmc   +1 more source

Modulating the gut microbiota in Crohn's disease: a pilot study on the impact of a plant-based diet with DNA-based monitoring. [PDF]

Front Nutr
Østergaard SK, Cetin Z, Rasmussen HH, Lærke HN, Holst M, Lauridsen C, Nielsen JL.   +6 more
europepmc   +1 more source

Letter to the editor on: "Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort". [PDF]

J Nutr Health Aging
Qiu L.
europepmc   +1 more source

Effects of plant-based diet on metabolic parameters, liver and kidney steatosis: a prospective interventional open-label study. [PDF]

Br J Nutr
Guler Senturk B, Gurses B, Soyturk C, Copur S, Incir S, Siriopol D, Hasbal NB, Akyildiz M, van Raalte DH, Kanbay M.   +9 more
europepmc   +1 more source

Quantitative Genetics of Feed-Efficiency-Related Traits for the Pacific Whiteleg Shrimp Penaeus vannamei in a Plant-Based Diet Environment. [PDF]

Biology (Basel)
Dai P, Zhu X, Luan S, Sui J, Meng X, Cao J, Tan J, Kong J.   +7 more
europepmc   +1 more source