Results 41 to 50 of about 64,161 (243)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Plant-based diet index among male footballers and their non-athlete controls. Is it associated with oxidative stress biomarkers?

, 2023
Abstract Background Since well-chosen nutrition exerts a vital role in modulating oxidative status, in addition plant-based diets represent a growing trend among athletes, our purpose was to determine plant-based diet index (PDI) score among male footballers and their non-athlete controls, as well as its association with oxidative biomarkers ...
Mahsa Zare, Mehran Nouri, Sahar Zare, Kimia Leilami, Parvin Sarbakhsh, Mohammad Hasan Eftekhari, Bahram Pourghassem Gargari   +6 more
openaire   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Interaction of genetic risk score (GRS) and Plant-Based diet on atherogenic factors and body fat distribution indices among women with overweight and obesity: a cross-sectional study

Scientific Reports
The association between plant-based diets, obesity, cardiovascular disease (CVD), and genetic predisposition is still not fully understood. This study explored how plant-based diets interact with genetic susceptibility to atherosclerosis and body fat in ...
Mahya Mehri Hajmir, Atieh Mirzababaei, Faezeh Abaj, Yasaman Aali, Mahsa Samadi, Khadijeh Mirzaei   +5 more
doaj   +1 more source

Association of changes in plant-based diet consumption with all-cause mortality among older adults in China: a prospective study from 2008 to 2019

The Journal of Nutrition, Health and Aging
Objectives: To examine the association of changes in plant-based diet consumption with all-cause mortality among older adults in China. Design: Cohort study. Setting: This cohort study of 11 years used data from the Chinese Longitudinal Healthy Longevity
Shen Huang, Yiling Lou, Shiqi Wang, Qiqi You, Qingqing Jiang, Shiyi Cao   +5 more
doaj   +1 more source

Analyzing dietary exposure to critical nutrients on a plant-based diet using the food- and total nutrient index

Nutrition Journal
Abstract Background Unfortified plant-based diets are devoid of vitamin B12, and supply low intakes of iodine, zinc, selenium, and calcium. To disentangle the complex interplay between nutritional adequacy and nutrient intakes from supplements and foods in plant-based diets, data from a Germany-based cross-sectional ...
Maximilian Andreas Storz, Frieda Stübing, Luciana Hannibal, Roman Huber   +3 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Association between the quality of plant‐based diets and risk of frailty

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background The Mediterranean diet and other dietary patterns rich in fruits and vegetables have been linked to lower risk of frailty in older adults. However, not all plant‐based diets are necessarily healthful, and no previous study has evaluated the ...
Mercedes Sotos‐Prieto, Ellen A. Struijk, Teresa T. Fung, Fernando Rodríguez‐Artalejo, Walter C. Willett, Frank B. Hu, Esther Lopez‐Garcia   +6 more
doaj   +1 more source