Results 171 to 180 of about 207,129 (257)

Lipoprotein(a) and Cardiovascular Disease: From Genetic Risk Factor to Therapeutic Target. [PDF]

Cells
Yun HR, Singh MK, Han S, Ranbhise JS, Ha J, Kim SS, Kang I.   +6 more
europepmc   +1 more source

Plasminogen Activator [PDF]

, 2020
openaire   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Tranexamic acid inhibits group A streptococci-mediated fibrinolysis <i>in vitro</i> and modulates host immune cells <i>in vivo</i>. [PDF]

Front Immunol
Possehl M, Vasudevan P, Schenk S, Maletzki C, David R, Kreikemeyer B, Oehmcke-Hecht S.   +6 more
europepmc   +1 more source

Thrombectomy versus Medical Management for Pediatric Acute Ischemic Stroke Due to Isolated M2 Occlusion: A Multicenter Cohort Study

Annals of Neurology, Volume 99, Issue 3, Page 684-691, March 2026.
Objective Endovascular thrombectomy (EVT) is increasingly used for pediatric large vessel occlusion (LVO) stroke, however, its role in isolated M2 occlusions remains underexplored. This study compared clinical outcomes in children with isolated M2 occlusion treated with EVT versus best medical therapy (BMT). Methods This multicenter cohort study pooled
Peter B. Sporns, Kartik D. Bhatia, Prakash Muthusami, Carmen Parra‐Farinas, Christine K. Fox, Adam A. Dmytriw, Basile Kerleroux, Sarah Lee, Jens Fiehler, Christian Lehmann, Franja Dugar, Todd Abruzzo, Lisa Pabst, Stuart Fraser, Lisa R. Sun, Grégoire Boulouis, Tanja Burkard, Olivier Naggara, Manoelle Kossorotoff, André Kemmling, Martin Olivieri, Mesha Martinez, Marios Psychogios, Thi Dan Linh Nguyen‐Kim, Moritz Wildgruber   +24 more
wiley   +1 more source

Urokinase Plasminogen Activator Deficiency Delays the Development of Obesity and Metabolic Sequelae. [PDF]

Arterioscler Thromb Vasc Biol
Hur WS, Patel YN, Abrahams SR, Wei Z, Hanes HE, Jameson AT, Negrón OA, Pedersen NB, Giacomazzo MSY, Bladbjerg EM, Wolberg AS, Luyendyk JP, Flick MJ.   +12 more
europepmc   +1 more source

Tenecteplase Versus Alteplase for First‐Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy

Annals of Neurology, Volume 99, Issue 3, Page 692-704, March 2026.
Objective The first‐pass effect (FPE), defined as excellent reperfusion after a single attempt, is associated with improved outcomes in large vessel occlusion stroke. We evaluated whether intravenous tenecteplase (TNK) compared with alteplase (TPA) increases the likelihood of FPE in basilar artery occlusion (BAO).
Dylan N. Wolman, Rahul R. Karamchandani, Sina Hemmer, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Clemens M. Schirmer, Alexandra R. Paul, Bradley N. Bohnstedt, Raul G. Nogueira, Philipp Hendrix   +38 more
wiley   +1 more source

Successful Use of Recombinant Tissue Plasminogen Activator in an Extremely Low Birth Weight Premature Infant for the Resolution of Multiple Thrombi. [PDF]

AJP Rep
Mody K, Wade C, Micetic B, Vernon M, Wade N.   +4 more
europepmc   +1 more source

Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?

Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.
Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin, Leonardo Palazzo, Agnes B. Fogo, Mark Haas, David R. W. Jayne, Liz Lightstone, Brad H. Rovin, Surya V. Seshan, Augusto Vaglio, Ioannis Parodis, Ingeborg M. Bajema, for the Lupus Nephritis Classification Steering Committee   +11 more
wiley   +1 more source

Novel compound heterozygous mutations in plasminogen (p.Gly568Arg/p.Ala620Thr) impair protein structure and function in type II deficiency: mechanistic insights into a hereditary thrombogenic disorder. [PDF]

Orphanet J Rare Dis
Lu Y, Wang F, Yu D, Xie H, Jin Y, Wang M, Yang L.   +6 more
europepmc   +1 more source