Results 181 to 190 of about 207,129 (257)

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.
ABSTRACT Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders. This commonality has led researchers to study the potential association, positive or negative, between blood cancers and allergy, but the results remain unclear.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
wiley   +1 more source

The Plasminogen Activation System in the Central Nervous System: Implications for Epilepsy and Neuropsychiatric Disorders. [PDF]

Int J Mol Sci
Suleymanova E, Karan A.
europepmc   +1 more source

Clotting and other plasma factors in septicemia [PDF]

, 1980
Fritz, Hans, Jochum, Marianne, Peeters, Hubert, Schießler, Hans, Witte, J.   +4 more
core  

Restricting Synaptotagmin‐3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re‐Programming

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Restriction of Syt3 internalization by peptide 3Y conferred robust neuroprotection against cerebral ischemia/reperfusion injury. Mechanistically, 3Y suppressed neuronal apoptosis fundamentally, and additionally, these salvaged neurons orchestrated and remodulated the transformation of surrounding microglia toward an anti‐inflammatory and ...
Hua Xu, Hongbo Mi, Rong Cheng, Tiantian Gui, Fangzhou Hu, Yi Yang, Jian Cheng, Qun Xue   +7 more
wiley   +1 more source

Congenital Holoprocencephaly, Hydrocephalus, and Dandy-Walker Malformation Due to Plasminogen Deficiency. [PDF]

Cureus
Antonakopoulos N, Perdikaris P, Styliara I, Tzela P, Adonakis G.   +4 more
europepmc   +1 more source

IL‐17A Promotes NETs Formation via the PKCζ–ERK–ROS–PAD4 Pathway in a Mouse Model of Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Our study demonstrates that IL‐17A promotes NET formation by upregulating PAD4 through the PKCζ–ERK–ROS pathway, thereby exacerbating ischemic brain injury. IL‐17A regulates NET formation through this newly identified molecular pathway, and targeting this pathway may offer a novel therapeutic strategy for stroke.
Chang Liu, Qi Chen, Weijia Chen, Xinyue Han, Xiaowen Qiao, Jun Guo, Wei Su, Qingqing Dai   +7 more
wiley   +1 more source

Thrombolytic proteins profiling: High-throughput activity, selectivity, and resistance assays. [PDF]

FEBS Open Bio
Toul M, Strunga A, Damborsky J, Prokop Z.   +3 more
europepmc   +1 more source

Inflammation in Idiopathic Intracranial Hypertension: An Immunometabolic Mechanistic Framework and Clinical Implications

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Systemic metabolic dysfunction and comorbidities may act as upstream modulators converging on inflammatory activation, which is closely intertwined with excessive CSF production and impaired clearance, potentially contributing to sustained ICP elevation.
Guangyu Han, Jiahao Song, Shuling Wan, Xunming Ji, Da Zhou, Ran Meng   +5 more
wiley   +1 more source

The interaction of fibrinolysis and the complement system in patients with acute pulmonary embolism, treated with ultrasound-assisted catheter-directed thrombolysis. [PDF]

Thromb J
Draxler DF, Barrett CD, Brodard J, Maginot ER, Chalkou K, Ho H, Keragala CB, Heg D, Kremer Hovinga JA, Moore EE, Medcalf RL, Angelillo-Scherrer A, Stortecky S.   +12 more
europepmc   +1 more source

GALNT3 Inhibits the Progression of Cerebral Ischemia–Reperfusion Injury by Stabilizing TREM2 via O‐GalNAc Glycosylation

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
The neuroprotective effect of GALNT3 against CIRI and the underlying mechanisms. GALNT3 directly interacts with and catalyzes the mucin‐type O‐GalNAcylation of TREM2 predominantly at serine 147, which enhances TREM2 protein stability. This GALNT3‐TREM2 axis suppresses the release of pro‐inflammatory cytokines, oxidative stress, and activation of M1 ...
Xinyi Fei, Jinghui Yang, Rui Zhang, Yu Zhang, Shan Yu   +4 more
wiley   +1 more source