Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus [PDF]
Frontiers in Cellular Neuroscience, 2015 Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development.
Daniel Ortuño-Sahagún, Mercè Pallàs
exaly +5 more sources
Pleiotrophin and metabolic disorders: insights into its role in metabolism [PDF]
Frontiers in Endocrinology, 2023 Pleiotrophin (PTN) is a cytokine which has been for long studied at the level of the central nervous system, however few studies focus on its role in the peripheral organs. The main aim of this review is to summarize the state of the art of what is known
Cristina Ballesteros-Pla +5 more
doaj +2 more sources
Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome [PDF]
Cell ReportsSummary: Neuronal dendrite patterning and synapse formation are tightly regulated during development to promote proper connectivity. Here, we identify downregulation of pleiotrophin, a secreted molecule enriched in astrocytes, as a major contributor to ...
Ashley N. Brandebura +6 more
doaj +2 more sources
Direct Relationship Between Heparin Binding to Midkine and Pleiotrophin and the Development of Acute Deep Vein Thrombosis [PDF]
BiomedicinesBackground/Objectives: The underlying molecular mechanisms of deep vein thrombosis (DVT), which continues to be a major global public health concern, remain unclear.
Suna Aydin +7 more
doaj +2 more sources
Expression analysis of macrodactyly identifies pleiotrophin upregulation. [PDF]
PLoS ONE, 2012 Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological features are preserved. Not
Frank H Lau +7 more
doaj +6 more sources
Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions [PDF]
Frontiers in GeneticsMicroglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors.
María Aránzazu Penedo +9 more
doaj +2 more sources
Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice [PDF]
Frontiers in PharmacologyAlzheimer’s disease (AD) is a major neurodegenerative disorder that courses with chronic neuroinflammation. Pleiotrophin (PTN) is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ which is upregulated in different ...
Teresa Fontán-Baselga +9 more
doaj +2 more sources
Nature Communications, 2017 Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in ...
Yi-Fang Ping, Wenchao Zhou, Zhi Huang
exaly +2 more sources
Targeting the PTN/PTPRZ1-ROS Pathway to Promote Bone Regeneration [PDF]
BiomedicinesBackground: Osteoporosis is a global health problem that significantly decreases patients’ quality of life and causes tremendous medical burdens. Therefore, exploring effective targeting strategies for osteoporosis treatment is crucial.
Kai Zhao +6 more
doaj +2 more sources
Beyond Amyloid: Targeting Co-Aggregating Proteins and Targeted Degradation Strategies in Alzheimer’s Disease [PDF]
BiomedicinesAlzheimer’s disease (AD) involves a constellation of molecular processes that extend well beyond amyloid-β (Aβ) accumulation. Recent anti-amyloid antibodies provide limited clinical benefits, highlighting the need for additional strategies due to their ...
Martina Monaco +2 more
doaj +2 more sources