Results 91 to 100 of about 6,090 (193)

Genetic deletion of pleiotrophin leads to disruption of spinal nociceptive transmission: Evidence for pleiotrophin modulation of morphine-induced analgesia

European Journal of Pharmacology, 2010
Pleiotrophin (PTN) is a growth factor that exhibits neurotrophic actions and is upregulated at sites of nerve injury. Upregulation of PTN levels in injured dorsal root ganglion correlates with decreased mechanical allodynia and faster recovery from Chronic Constriction Injury of the rat sciatic nerve.
Gramage, Esther, Herradón Gil-Gallardo, Gonzalo   +1 more
openaire   +3 more sources

Wave front migration of endothelial cells in a bone-implant interface [PDF]

, 2011
The neo-vascularization of the host site is crucial for the primary fixation and the long-term stability of the bone-implant interface. Our aim was to investigate the progression of endothelial cell population in the first weeks of healing. We proposed a
Khalil, Georges, Lorthois, Sylvie, Mansat, Pierre, Marcoux, Manuel, Swider, Pascal   +4 more
core   +3 more sources

Pleiotrophin Regulates the Retention and Self-Renewal of Hematopoietic Stem Cells in the Bone Marrow Vascular Niche

Cell Reports, 2012
The mechanisms through which the bone marrow (BM) microenvironment regulates hematopoietic stem cell (HSC) fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN) in regulating HSC function in the
Heather A. Himburg, Jeffrey R. Harris, Takahiro Ito, Pamela Daher, J. Lauren Russell, Mamle Quarmyne, Phuong L. Doan, Katherine Helms, Mai Nakamura, Emma Fixsen, Gonzalo Herradon, Tannishtha Reya, Nelson J. Chao, Sheila Harroch, John P. Chute   +14 more
doaj   +1 more source

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs [PDF]

, 2016
fusion between the EML4 (echinoderm microtubule-associated protein-like) and ALK (anaplastic lymphoma kinase) genes was identified in non-small cell lung cancer (NSCLC) in 2007 and there has been rapid progress in applying this knowledge to the benefit ...
Bayliss, R, Choi, J, Fennell, DA, Fry, AM, Richards, MW   +4 more
core   +2 more sources

miR-137 Inhibits Proliferation and Metastasis of Hypertrophic Scar Fibroblasts via Targeting Pleiotrophin

Cellular Physiology and Biochemistry, 2018
Background/Aims: There are few effective treatment options for hypertrophic scars. MircoRNAs are a class of small, noncoding RNAs involved in multiple biological functions.
Qian Zhang, Bingyu Guo, Qiang Hui, Peng Chang, Kai Tao   +4 more
doaj   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source

Simulated Microgravity Regulates Gene Transcript Profiles of 2T3 Preosteoblasts: Comparison of the Random Positioning Machine and the Rotating Wall Vessel Bioreactor [PDF]

Microgravity of spaceflight induces bone loss due in part to decreased bone formation by osteoblasts. We have previously examined the microgravity-induced changes in gene expression profiles in 2T3 preosteoblasts using the Random Positioning Machine (RPM)
Hanjoong, Jo, Liu, Wenbin, Patel, Mamta J., Risin, Diana, Risin, Semyon A., Sykes, Michelle C., Ward, Nancy E.   +6 more
core   +1 more source

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

Neurobiology of Disease
Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. Pleiotrophin (PTN) is a cytokine that
Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón   +7 more
doaj   +1 more source

Mea6/cTAGE5 cooperates with TRAPPC12 to regulate PTN secretion and white matter development

iScience
Summary: Mutations of TRAPPC12 are associated with progressive childhood encephalopathy including abnormal white matter. However, the underlying pathogenesis is still unclear.
Tiantian Ma, Yaqing Wang, Laikang Yu, Jinghua Liu, Tao Wang, Pengyu Sun, Yinghang Feng, Dan Zhang, Lei Shi, Kangmin He, Li Zhao, Zhiheng Xu   +11 more
doaj   +1 more source

Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis [PDF]

, 2014
Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration. Objective: To study the correlation between MK serum levels and concentration of inflammatory cytokines ...
Ashtari, Fereshteh., Dehghani, Leila., Gharagozloo, Marjan., Hasheminia, Seyed Javad., Jamshidian, Azam., Montazeri, Saeed., Shaygannejad, Vahid., Tahani, Soheil., Vesal, Sahar.   +8 more
core   +1 more source