Results 11 to 20 of about 6,090 (193)
Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics
Pharmaceuticals, 2022 Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.
Jonathan R. Miles +3 more
doaj +4 more sources
Pleiotrophin Expression and Actions in Pancreatic β-Cells [PDF]
Frontiers in Endocrinology, 2022 Pleiotrophin (PTN) is a heparin-binding cytokine that is widely expressed during early development and increases in maternal circulation during pregnancy.Aged PTN-deficient mice exhibit insulin resistance, suggesting a role in metabolic control.
Julio Sevillano +11 more
doaj +3 more sources
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer. [PDF]
PLoS ONE, 2016 BACKGROUND:Thyroid nodules are common, and approximately 5% of these nodules are malignant. Pleiotrophin (PTN) is a heparin-binding growth factor which is overexpressed in many cancers.
Youn Hee Jee +9 more
doaj +4 more sources
Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice. [PDF]
PLoS ONE, 2014 Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and neuroprotective effects that is involved in a variety of neurodevelopmental processes.
Jason W Krellman +4 more
doaj +3 more sources
The effects of pleiotrophin in proliferative diabetic retinopathy. [PDF]
PLoS ONE, 2015 Pleiotrophin (PTN), a secreted, multifunctional cytokine, is involved in angiogenic, fibrotic and neurodegenerative diseases. However, little is known about its effects on diabetic retinopathy, a neurovascular disease.
Xuemei Zhu +11 more
doaj +4 more sources
PLoS ONE, 2012 Bone is a complex dynamic tissue undergoing a continuous remodeling process. Gravity is a physical force playing a role in the remodeling and contributing to the maintenance of bone integrity.
Sara Tavella +2 more
exaly +3 more sources
PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior [PDF]
Nature CommunicationsMania is a complex psychiatric disease characterized by hyperactivity, elevated mood and reduced anxiety. Despite extensive studies on the mechanism of the manic episodes, the molecular targets that control manic pathogenesis remain largely unclear. Here,
Hongwon Kim +7 more
doaj +2 more sources
Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer [PDF]
, 2010 Lung cancer is the leading cause of cancer deaths, because ~84% of cases are diagnosed at an advanced stage. Worldwide in 2008, ~1.5 million people were diagnosed and ~1.3 million died – a survival rate unchanged since 1960.
Alex Stewart +14 more
core +23 more sources
Pleiotrophin fights Brd2 for neuronal differentiation
Neural Regeneration Research, 2015 Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucía, Spain, grant number P12-CTS-2064.
Pablo Garcia-Gutierrez +1 more
doaj +4 more sources
Association of serum pleiotrophin levels with acute coronary syndrome
International Journal of the Cardiovascular Academy, 2022 Background and Aim: Pleiotrophin (PTN) is known as a multifunctional cytokine and a neurite outgrowth-promoting factor and appears as an angiogenic response to numerous processes such as ischemic injury affecting a region of the heart and the brain.
Funda Basyigit +4 more
doaj +1 more source