Results 11 to 20 of about 7,167 (241)
Pleiotrophin Expression and Actions in Pancreatic β-Cells [PDF]
Frontiers in Endocrinology, 2022 Pleiotrophin (PTN) is a heparin-binding cytokine that is widely expressed during early development and increases in maternal circulation during pregnancy.Aged PTN-deficient mice exhibit insulin resistance, suggesting a role in metabolic control.
Julio Sevillano +11 more
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miR-338-3p promotes radiation recall like dermatitis by suppressing pleiotrophin via the PI3K/Akt/Bcl2 pathway [PDF]
Molecular BiomedicineRadiation recall dermatitis (RRD) is a rare but severe inflammatory reaction induced by certain drugs in previously irradiated skin, which can markedly impair quality of life and disrupt cancer treatment.
Yu Min +7 more
doaj +3 more sources
Pleiotrophin-Loaded Mesoporous Silica Nanoparticles as a Possible Treatment for Osteoporosis
Pharmaceutics, 2023 Osteoporosis is the most common type of bone disease. Conventional treatments are based on the use of antiresorptive drugs and/or anabolic agents. However, these treatments have certain limitations, such as a lack of bioavailability or toxicity in non ...
Daniel Lozano +6 more
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Pleiotrophin Interaction with Synthetic Glycosaminoglycan Mimetics
Pharmaceuticals, 2022 Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo. Some structures of PTN in solution have been solved, but no precise location of the binding site has been reported yet.
Jonathan R. Miles +3 more
doaj +4 more sources
Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex
Cells, 2023 During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species.
Margarita Belem Santana-Bejarano +7 more
doaj +2 more sources
Cell Reports, 2023 Summary: Cognitive impairment has been associated with an age-related decline in adult hippocampal neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging hippocampus remains to be elucidated.
Haoyang Li +12 more
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Pleiotrophin: Activity and mechanism.
Advances in Clinical Chemistry, 2020 Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide glycosaminoglycan (GAG). Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also ...
Xu Wang
semanticscholar +4 more sources
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer. [PDF]
PLoS ONE, 2016 BACKGROUND:Thyroid nodules are common, and approximately 5% of these nodules are malignant. Pleiotrophin (PTN) is a heparin-binding growth factor which is overexpressed in many cancers.
Youn Hee Jee +9 more
doaj +4 more sources
Behavioral and neuroanatomical abnormalities in pleiotrophin knockout mice. [PDF]
PLoS ONE, 2014 Pleiotrophin (PTN) is an extracellular matrix-associated protein with neurotrophic and neuroprotective effects that is involved in a variety of neurodevelopmental processes.
Jason W Krellman +4 more
doaj +3 more sources
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation
Frontiers in Immunology, 2022 Astrocytes are the most abundant glial cells in the central nervous system (CNS) with the capacity to sense and react to injury and inflammatory events. While it has been widely documented that astrocytes can exert tissue-degenerative functions, less is ...
Mathias Linnerbauer +6 more
doaj +2 more sources