Results 21 to 30 of about 6,090 (193)
Biomedicines, 2023 Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ.
María Rodríguez-Zapata +12 more
doaj +1 more source
Pleiotrophin-Loaded Mesoporous Silica Nanoparticles as a Possible Treatment for Osteoporosis
Pharmaceutics, 2023 Osteoporosis is the most common type of bone disease. Conventional treatments are based on the use of antiresorptive drugs and/or anabolic agents. However, these treatments have certain limitations, such as a lack of bioavailability or toxicity in non ...
Daniel Lozano +6 more
doaj +1 more source
Pleiotrophin Expression during Odontogenesis [PDF]
Journal of Histochemistry & Cytochemistry, 2012 Pleiotrophin (PTN) is an extracellular matrix–associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. There is limited information currently available about PTN expression during odontoblast differentiation and tooth formation, and thus the authors ...
Heidi, Erlandsen +8 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on PTN (pleiotrophin), with data on DNA, on the protein encoded, and where the gene is implicated.
Pantazaka, E, Papadimitriou, E
openaire +2 more sources
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
doaj +1 more source
Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex
Cells, 2023 During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species.
Margarita Belem Santana-Bejarano +7 more
doaj +1 more source
Pleiotrophin regulates microglia-mediated neuroinflammation [PDF]
Journal of Neuroinflammation, 2017 Pleiotrophin (PTN) is a cytokine found highly upregulated in the brain in different disorders characterized by overt neuroinflammation such as neurodegenerative diseases, drug addiction, traumatic injury, and ischemia. In the present work, we have explored whether PTN modulates neuroinflammation and if Toll-like receptor 4 (TLR4), crucial in the ...
Fernández-Calle, Rosalía +8 more
openaire +2 more sources
Cells, 2020 Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration.
Yu-Hee Kim +7 more
doaj +1 more source
Frontiers in Neurology, 2021 Heparin-binding growth-associated molecule (pleiotrophin) is a neurite outgrowth-promoting secretory protein that lines developing fiber tracts in juvenile CNS (central nervous system).
Natalia Kulesskaya +6 more
doaj +1 more source
Neuroinflammation and Its Resolution: From Molecular Mechanisms to Therapeutic Perspectives [PDF]
, 2020 Neuroinflammation, the complex immune response of the central nervous system (CNS), when sustained, is a common denominator in the etiology and course of all major neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric ...
Berwian +11 more
core +2 more sources