Results 21 to 30 of about 7,167 (241)

Heparin-Modified Collagen Gels for Controlled Release of Pleiotrophin: Potential for Vascular Applications

Frontiers in Bioengineering and Biotechnology, 2019
A fast re-endothelialization, along with the inhibition of neointima hyperplasia, are crucial to reduce the failure of vascular bypass grafts. Implants modifications with molecules capable of speeding up the re-endothelialization process have been ...
Francesco Copes, Francesco Copes, Pascale Chevallier, Caroline Loy, Daniele Pezzoli, Francesca Boccafoschi, Francesca Boccafoschi, Diego Mantovani   +7 more
doaj   +3 more sources

The effects of pleiotrophin in proliferative diabetic retinopathy. [PDF]

PLoS ONE, 2015
Pleiotrophin (PTN), a secreted, multifunctional cytokine, is involved in angiogenic, fibrotic and neurodegenerative diseases. However, little is known about its effects on diabetic retinopathy, a neurovascular disease.
Xuemei Zhu, Yujing Bai, Wenzhen Yu, Chungting Pan, Enzhong Jin, Dan Song, Qiong Xu, Yuou Yao, Lvzhen Huang, Yong Tao, Xiaoxin Li, Mingwei Zhao   +11 more
doaj   +4 more sources

Bone turnover in wild type and pleiotrophin-transgenic mice housed for three months in the International Space Station (ISS).

PLoS ONE, 2012
Bone is a complex dynamic tissue undergoing a continuous remodeling process. Gravity is a physical force playing a role in the remodeling and contributing to the maintenance of bone integrity.
Sara Tavella, Alessandra Ruggiu, Alessandra Giuliani, Francesco Brun, Barbara Canciani, Adrian Manescu, Katia Marozzi, Michele Cilli, Delfina Costa, Yi Liu, Federica Piccardi, Roberta Tasso, Giuliana Tromba, Franco Rustichelli, Ranieri Cancedda   +14 more
doaj   +3 more sources

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling

The Journal of Clinical Investigation, 2022
Dysfunction of protein trafficking has been intensively associated with neurological diseases, including neurodegeneration, but whether and how protein transport contributes to oligodendrocyte (OL) maturation and myelin repair in white matter injury ...
Zhixiong Liu, Minbiao Yan, Wanying Lei, Rencai Jiang, Wenxiu Dai, Jialin Chen, Chaomeng Wang, Li Li, Mei Wu, Ximing Nian, Daopeng Li, Di Sun, Xiaoqi Lv, Chaoying Wang, Changchuan Xie, Luming Yao, Caiming Wu, Jin Hu, Naian Xiao, Wei Mo, Zhanxiang Wang, Liang Zhang   +21 more
doaj   +2 more sources

Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus

Neurobiology of Disease
Obesity and metabolic disorders, such as metabolic syndrome (MetS) facilitate the development of neurodegenerative diseases and cognitive decline. Persistent neuroinflammation plays an important role in this process. Pleiotrophin (PTN) is a cytokine that
Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón   +7 more
doaj   +2 more sources

Pleiotrophin/Midkine Pathway Is Dysregulated in a TDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis (ALS). [PDF]

Neuropathology
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Martínez-Alesón P, Benito-Casado C, Fernández-Martos CM, Polanco Mora MJ.   +3 more
europepmc   +2 more sources

PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior [PDF]

Nature Communications
Mania is a complex psychiatric disease characterized by hyperactivity, elevated mood and reduced anxiety. Despite extensive studies on the mechanism of the manic episodes, the molecular targets that control manic pathogenesis remain largely unclear. Here,
Hongwon Kim, Byounggook Cho, Hyung Kyu Kim, Soi Kang, Saemin An, Daeyeol Kwon, Hee Young Kim, Jongpil Kim   +7 more
doaj   +2 more sources

Regulation of Pleiotrophin and PTPRZ1 Expression by Hypoxia to Restrict Hypoxia-Induced Cell Migration. [PDF]

Cancers (Basel)
Simple Summary Hypoxia regulates gene expression to support tumor cell invasion and angiogenesis. Hypoxia-inducible transcription factors (HIFs) play a major role in the hypoxia effects through interactions with other transcription factors, such as AP-1.
Poimenidi E, Droggiti E, Karavasili K, Kotsirilou D, Mourkogianni E, Koolwijk P, Papadimitriou E.   +6 more
europepmc   +2 more sources

The roles of pleiotrophin in brain injuries: a narrative review of the literature. [PDF]

Ann Med
Background Pleiotrophin (PTN), a secreted multifunctional growth factor, is highly expressed in the developing brain. Recently, many studies have indicated that PTN participates in the development of brain and plays a neuroprotection after brain injury ...
Lei Y, Zhou R, Mao Q, Qiu X, Mu D.
europepmc   +2 more sources

Pleiotrophin fights Brd2 for neuronal differentiation

Neural Regeneration Research, 2015
Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucía, Spain, grant number P12-CTS-2064.
Pablo Garcia-Gutierrez, Mario Garcia-Dominguez   +1 more
doaj   +4 more sources