Association of serum pleiotrophin levels with acute coronary syndrome
International Journal of the Cardiovascular Academy, 2022 Background and Aim: Pleiotrophin (PTN) is known as a multifunctional cytokine and a neurite outgrowth-promoting factor and appears as an angiogenic response to numerous processes such as ischemic injury affecting a region of the heart and the brain.
Funda Basyigit +4 more
doaj +1 more source
Biomedicines, 2023 Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ.
María Rodríguez-Zapata +12 more
doaj +1 more source
Pleiotrophin Overexpression Reduces Adolescent Ethanol Consumption and Modulates Ethanol-Induced Glial Responses and Changes in the Perineuronal Nets in the Mouse Hippocampus. [PDF]
CNS Neurosci TherTo investigate whether pleiotrophin (PTN) overexpression influences ethanol consumption during adolescence and its effects on glial responses, neurogenesis, and perineuronal nets (PNNs) in the mouse hippocampus.
Galán-Llario M +7 more
europepmc +2 more sources
Prognostic evaluation of oral squamous cell carcinoma based on pleiotrophin, urokinase plasminogen activator, and glycoprotein nonmetastatic melanoma protein B expression. [PDF]
Medicine (Baltimore), 2023 This study investigated the expression of pleiotrophin (PTN), urokinase plasminogen activator (uPA), and glycoprotein nonmetastatic melanoma protein B (GPNMB) in oral squamous cell carcinoma (OSCC) tissues and their correlation with prognosis.
Ma Y, Liu Y, Meng H.
europepmc +2 more sources
Pleiotrophin Expression during Odontogenesis [PDF]
Journal of Histochemistry & Cytochemistry, 2012 Pleiotrophin (PTN) is an extracellular matrix–associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. There is limited information currently available about PTN expression during odontoblast differentiation and tooth formation, and thus the authors ...
Heidi, Erlandsen +8 more
openaire +2 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on PTN (pleiotrophin), with data on DNA, on the protein encoded, and where the gene is implicated.
Pantazaka, E, Papadimitriou, E
openaire +2 more sources
Neuroinflammation and Its Resolution: From Molecular Mechanisms to Therapeutic Perspectives [PDF]
, 2020 Neuroinflammation, the complex immune response of the central nervous system (CNS), when sustained, is a common denominator in the etiology and course of all major neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric ...
Berwian +11 more
core +2 more sources
Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
doaj +1 more source
Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice. [PDF]
Int J Mol SciPleiotrophin (PTN) is crucial for embryonic development and pancreas organogenesis as it regulates metainflammation, metabolic homeostasis, thermogenesis, and glucose tolerance. Pleiotrophin deletion is associated with a lipodystrophic phenotype in which
Ballesteros-Pla C +11 more
europepmc +2 more sources
Pleiotrophin regulates microglia-mediated neuroinflammation [PDF]
Journal of Neuroinflammation, 2017 Pleiotrophin (PTN) is a cytokine found highly upregulated in the brain in different disorders characterized by overt neuroinflammation such as neurodegenerative diseases, drug addiction, traumatic injury, and ischemia. In the present work, we have explored whether PTN modulates neuroinflammation and if Toll-like receptor 4 (TLR4), crucial in the ...
Fernández-Calle, Rosalía +8 more
openaire +2 more sources