Results 31 to 40 of about 6,090 (193)
Relationship Between Serum Concentrations of the Growth Factor Pleiotrophin and Pleiotrophin-Positive Tumors [PDF]
JNCI: Journal of the National Cancer Institute, 1998 Growth factors produced by tumor cells are essential for tumor expansion and may be useful in monitoring tumor progression or therapeutic efficacy if the factors are released into the circulation. In this study, we measured serum levels of pleiotrophin, a secreted heparin-binding growth and angiogenesis factor, in mice bearing human tumor xenografts to
B, Souttou +7 more
openaire +2 more sources
A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ
Molecular Cancer, 2010 Background Pleiotrophin, also known as HARP (Heparin Affin Regulatory Peptide) is a growth factor expressed in various tissues and cell lines. Pleiotrophin participates in multiple biological actions including the induction of cellular proliferation ...
Diamantopoulou Zoi +6 more
doaj +1 more source
Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats
Molecular Neurodegeneration, 2011 Background Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients.
Pitossi Fernando J +6 more
doaj +1 more source
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]
, 2014 Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A. +6 more
core +2 more sources
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
core +1 more source
Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma
Pharmaceuticals, 2011 RNA interference (RNAi) allows the specific knockdown of tumor relevant genes. To induce RNAi, the delivery of small interfering RNAs (siRNAs) is of crucial importance. This is particularly challenging for their therapeutic applications in vivo.
Achim Aigner +3 more
doaj +1 more source
The expression and function of midkine in the vertebrate retina [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102704/1/bph12495 ...
Cameron DA +8 more
core +1 more source
Domain Structure of Pleiotrophin Required for Transformation [PDF]
Journal of Biological Chemistry, 1999 The pleiotrophin (PTN) gene (Ptn) is a potent proto-oncogene that is highly expressed in many primary human tumors and constitutively expressed in cell lines derived from these tumors. The product of the Ptn gene is a secreted 136-amino acid heparin binding cytokine with distinct lysine-rich clusters within both the N- and C-terminal domains.
N, Zhang, R, Zhong, T F, Deuel
openaire +2 more sources
ALK activation, ligands and therapeutic targets in glioblastoma and other cancers
Frontiers in Oncology, 2012 The intracellular anaplastic lymphoma kinase (ALK) fragment shows striking homology with members of the insulin receptor family and was initially identified as an oncogenic fusion protein resulting from a translocation in lymphoma and more recently in a ...
Anton eWellstein
doaj +1 more source
International Journal of the Cardiovascular Academy, 2023 Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI)
Serdar Gökhan Nurkoç +4 more
doaj +1 more source