Results 51 to 60 of about 6,090 (193)
Proteoglycans and neuronal migration in the cerebral cortex during development and disease [PDF]
, 2015 Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki Maeda
core +2 more sources
Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]
, 2017 Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G +2 more
core +3 more sources
Frontiers in Pharmacology, 2019 Inflammation is a common factor of pathologies such as obesity, type 2 diabetes or neurodegenerative diseases. Chronic inflammation is considered part of the pathogenic mechanisms of different disorders associated with aging.
Gonzalo Herradon +2 more
doaj +1 more source
Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration [PDF]
, 2018 Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and ανβ3 integrin.
A Bogush +53 more
core +2 more sources
Expression of VEGF and pleiotrophin in deer antler [PDF]
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006 AbstractDeer antlers represent a unique model of mammalian regeneration in that they cast and fully regenerate every year. The deer antler thus provides a fascinating model of both rapid angiogenesis and chondrogenesis and the opportunity to investigate unique growth regulatory processes. One such phenomenon is the presence of vascularized cartilage in
Dawn E, Clark +2 more
openaire +2 more sources
Frontiers in Bioengineering and Biotechnology, 2019 A fast re-endothelialization, along with the inhibition of neointima hyperplasia, are crucial to reduce the failure of vascular bypass grafts. Implants modifications with molecules capable of speeding up the re-endothelialization process have been ...
Francesco Copes +7 more
doaj +1 more source
Pleiotrophin: Activity and mechanism
, 2020 Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide glycosaminoglycan (GAG). Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also been linked to a plethora of other physiological events including cancer metastasis, angiogenesis ...
openaire +3 more sources
Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma [PDF]
, 2016 Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored.
Fillerová, Regina +9 more
core +1 more source
The effect of pleiotrophin signaling on adipogenesis
FEBS Letters, 2007 Pleiotrophin (PTN) plays diverse roles in cell growth and differentiation. In this investigation, we demonstrate that PTN plays a negative role in adipogensis and that glycogen synthase kinase 3β (GSK‐3β) and β‐catenin are involved in the regulation of PTN‐mediated preadipocyte differentiation.
Gu, Dayong +7 more
openaire +2 more sources
The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. [PDF]
PLoS ONE, 2014 Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2.
Fredrik Hugosson +5 more
doaj +1 more source