Pleiotrophin drives a prometastatic immune niche in breast cancer
Journal of Experimental Medicine, 2023 Metastatic cancer cells thrive in secondary organs by producing PTN and activating the NF-κB pathway. This leads to increased cytokine production, neutrophil recruitment, and T cell dysfunction.
Debolina Ganguly +13 more
semanticscholar +1 more source
Domain Structure of Pleiotrophin Required for Transformation [PDF]
Journal of Biological Chemistry, 1999 The pleiotrophin (PTN) gene (Ptn) is a potent proto-oncogene that is highly expressed in many primary human tumors and constitutively expressed in cell lines derived from these tumors. The product of the Ptn gene is a secreted 136-amino acid heparin binding cytokine with distinct lysine-rich clusters within both the N- and C-terminal domains.
N, Zhang, R, Zhong, T F, Deuel
openaire +2 more sources
The expression and function of midkine in the vertebrate retina [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102704/1/bph12495 ...
Cameron DA +8 more
core +1 more source
ALK activation, ligands and therapeutic targets in glioblastoma and other cancers
Frontiers in Oncology, 2012 The intracellular anaplastic lymphoma kinase (ALK) fragment shows striking homology with members of the insulin receptor family and was initially identified as an oncogenic fusion protein resulting from a translocation in lymphoma and more recently in a ...
Anton eWellstein
doaj +1 more source
International Journal of the Cardiovascular Academy, 2023 Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI)
Serdar Gökhan Nurkoç +4 more
doaj +1 more source
Pleiotrophin Activates cMet- and mTORC1-Dependent Protein Synthesis through PTPRZ1-The Role of ανβ3 Integrin. [PDF]
Int J Mol SciPleiotrophin (PTN) is a secreted factor that regulates endothelial cell migration through protein tyrosine phosphatase receptor zeta 1 (PTPRZ1) and αvβ3 integrin. Genetic deletion of Ptprz1 results in enhanced endothelial cell proliferation and migration,
Mourkogianni E +5 more
europepmc +2 more sources
ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland [PDF]
, 2013 Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Fulda, Simone +3 more
core +2 more sources
Antibody Characterization Report for Pleiotrophin
, 2022 Head-to-head comparison of available commercial antibodies against Pleiotrophin by immunoblot (Western blot) and immunoprecipitation on culture media. Work reported in this report was supported in part by the Emory-Sage-SGC TREAT-AD center established by the National Institutes of Aging under award number U54AG065187.
Ayoubi, Riham +3 more
openaire +1 more source
Loss of parafollicular cells during gravitational changes (microgravity, hypergravity) and the secret effect of pleiotrophin. [PDF]
PLoS ONE, 2012 It is generally known that bone loss is one of the most important complications for astronauts who are exposed to long-term microgravity in space. Changes in blood flow, systemic hormones, and locally produced factors were indicated as important elements
Elisabetta Albi +8 more
doaj +1 more source
Chondroitin sulfates and their binding molecules in the central nervous system [PDF]
, 2017 Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a ...
Djerbal, L, Kwok, JCF, Lortat-Jacob, H
core +3 more sources