Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species [PDF]
, 2015 Pleiotrophin (PTN) is a heparin-binding growth factor that induces cell migration through binding to its receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and integrin alpha v beta 3 (ανβ3).
Abdulnour +57 more
core +1 more source
The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells [PDF]
, 2016 The angiogenic inducer CCN1 (Cysteine-rich 61, CYR61) is differentially activated in metastatic breast carcinomas. However, little is known about the precise mechanisms that underlie the pro-metastatic actions of CCN1. Here, we investigated the impact of
Espinoza, Ingrid +3 more
core +1 more source
Pleiotrophin mediates hematopoietic regeneration via activation of RAS [PDF]
Journal of Clinical Investigation, 2014 Hematopoietic stem cells (HSCs) are highly susceptible to ionizing radiation-mediated death via induction of ROS, DNA double-strand breaks, and apoptotic pathways. The development of therapeutics capable of mitigating ionizing radiation-induced hematopoietic toxicity could benefit both victims of acute radiation sickness and patients undergoing ...
Himburg, Heather A +8 more
openaire +4 more sources
Pleiotrophin promotes perineural invasion in pancreatic cancer
World Journal of Gastroenterology, 2013 Perineural invasion (PNI) in pancreatic cancer is an important cause of local recurrence, but little is known about its mechanism. Pleiotrophin (PTN) is an important neurotrophic factor. It is of interest that our recent experimental data showed its involvement in PNI of pancreatic cancer.
Jun, Yao +3 more
openaire +2 more sources
Pleiotrophin commits human bone marrow mesenchymal stromal cells towards hypertrophy during chondrogenesis. [PDF]
PLoS ONE, 2014 Pleiotrophin (PTN) is a growth factor present in the extracellular matrix of the growth plate during bone development and in the callus during bone healing.
Thibault Bouderlique +8 more
doaj +1 more source
Dissecting the spermatogonial stem cell niche using spatial transcriptomics
Cell Reports, 2023 Summary: Spermatogonial stem cells (SSCs) in the testis support the lifelong production of sperm. SSCs reside within specialized microenvironments called “niches,” which are essential for SSC self-renewal and differentiation.
Shreya Rajachandran +11 more
doaj +1 more source
The role of pleiotrophin and β-catenin in fetal lung development
Respiratory Research, 2010 Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins.
Weng Tingting, Liu Lin
doaj +1 more source
Midkine mediates intercellular crosstalk between drug-resistant and drug sensitive neuroblastoma cells in vitro and in vivo [PDF]
, 2013 Resistance to cytotoxic agents has long been known to be a major limitation in the treatment of human cancers. Although many mechanisms of drug resistance have been identified, chemotherapies targeting known mechanisms have failed to lead to effective ...
Chou, Pauline M +9 more
core +3 more sources
Endogenous pleiotrophin and midkine regulate LPS-induced glial responses [PDF]
Neuroscience Letters, 2018 Pleiotrophin (PTN) and Midkine (MK) are two growth factors that modulate neuroinflammation. PTN overexpression in the brain prevents LPS-induced astrocytosis in mice but potentiates microglial activation. The modest astrocytic response caused by a low dose of LPS (0.5mg/kg) is blocked in the striatum of MK-/- mice whereas microglial response is ...
Rosalía, Fernández-Calle +6 more
openaire +2 more sources
Targeting Receptor-Type Protein Tyrosine Phosphatases with Biotherapeutics: Is Outside-in Better than Inside-Out? [PDF]
, 2018 Protein tyrosine phosphatases (PTPs), of the receptor and non-receptor classes, are key signaling molecules that play critical roles in cellular regulation underlying diverse physiological events.
Alastair Barr +4 more
core +2 more sources