Results 71 to 80 of about 7,167 (241)

Memory impairment due to recurrent vascular insults in mice was rescued by pleiotrophin

Alzheimer's & Dementia, 2023
Small vessel infarcts, ischemic attacks, microbleeds are considered a common cause of vascular dementia appears as white matter hyperintensities (WMH) in MRI of many patients.
Mayank Gupta, Ankita Talukdar, Rehab Hussain, L. Diwakar   +3 more
semanticscholar   +1 more source

A dual role for pleiotrophin in modulating inflammation and myelination in the presence of chondroitin sulfate proteoglycans after nervous system injury

Frontiers in Cellular Neuroscience
Chondroitin sulfate proteoglycans (CSPGs), key components of the extracellular matrix and the glial scar that forms around central nervous system (CNS) injuries, are recognized for hindering neuronal regeneration. We previously demonstrated the potential
Somnath J Gupta, M. Churchward, Katherine G. Todd, I. Winship   +3 more
semanticscholar   +1 more source

Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome

bioRxiv, 2023
Neuronal dendrite patterning and synapse formation are tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors during development, but little is known about how ...
Ashley N. Brandebura, Quinn N. Asbell, M. K. B. Micael, Nicola J. Allen   +3 more
semanticscholar   +1 more source

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development

Frontiers in Pharmacology, 2019
Inflammation is a common factor of pathologies such as obesity, type 2 diabetes or neurodegenerative diseases. Chronic inflammation is considered part of the pathogenic mechanisms of different disorders associated with aging.
Gonzalo Herradon, M. Pilar Ramos-Alvarez, Esther Gramage   +2 more
doaj   +1 more source

Expression of VEGF and pleiotrophin in deer antler [PDF]

The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006
AbstractDeer antlers represent a unique model of mammalian regeneration in that they cast and fully regenerate every year. The deer antler thus provides a fascinating model of both rapid angiogenesis and chondrogenesis and the opportunity to investigate unique growth regulatory processes. One such phenomenon is the presence of vascularized cartilage in
Dawn E, Clark, Eric A, Lord, James M, Suttie   +2 more
openaire   +2 more sources

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration [PDF]

, 2018
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and ανβ3 integrin.
A Bogush, A Hernandez, A Polykratis, AH Hawasli, C González-Castillo, C Heiss, C Marinaccio, C Mikelis, DH Ausprunk, E Contreras-Vallejos, E Lampropoulou, E Papadimitriou, E Papadimitriou, E Szabat, E Řezníčková, G Herradón, H Merk, H Pariser, H Yanagisawa, HJ Yeh, J Herzog, J Liebl, J Liebl, J Liebl, J Yao, JK Jin, K Meng, K Shah, K Shah, KO Lai, KP Sarker, L He, LJ Zhang, M Koutsioumpa, M Koutsioumpa, M Koutsioumpa, M Nikolic, MA Fousteris, MH Lee, MJ Xavier, MM Mandl, MR Hellmich, MR Sharma, N Franceschi De, N Mitsios, N Olmo del, ND Amin, S Tsirmoula, S Zhang, SB Weitensteiner, SS Sun, T Skillbäck, V Lalioti, Y Gao   +53 more
core   +2 more sources

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species [PDF]

, 2015
Pleiotrophin (PTN) is a heparin-binding growth factor that induces cell migration through binding to its receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and integrin alpha v beta 3 (ανβ3).
Abdulnour, Antoine, Bir, Bryan, Dhar-Mascareno, Dupont, Evangelia Papadimitriou, Goitre, Griguer, Güleç, Hatziapostolou, Hatziapostolou, Heissig, Heumüller, Holmström, Kalyanaraman, Kim, Kojima, Komaki, Kou, Koutsioumpa, Lange, Li, Linder, Lisanti, Lu, Margarita Lamprou, Maria Hatziapostolou, Mikelis, Naik, Nelly Kieffer, Nomura, Omori, Pantazaka, Papadimitriou, Polykratis, Polytarchou, Polytarchou, Polytarchou, Polytarchou, Prajda, Prajda, Ray, Romagnoli, Sabán-Ruiz, Samra, Schröder, Sies, Silver, Sotiria Tsirmoula, Terman, Tsirmoula, Ushio-Fukai, Wang, Wilkinson-Berka, Wind, Yokoi, Zhang   +57 more
core   +1 more source

A Subpopulation of Luminal Progenitors Secretes Pleiotrophin to Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer

Cancer Research
Nonmalignant luminal progenitor cells expressing pleiotrophin promote angiogenesis by activating NRP1 and induce a prometastatic tumor microenvironment in inflammatory breast cancer, providing potential therapeutic targets for this aggressive breast ...
Mengmeng Zhang, Kaiwen Zhou, Zilin Wang, Ting Liu, Laura E Stevens, F. Lynce, Wendy Y. Chen, Sui Peng, Yubin Xie, Duanyang Zhai, Qianjun Chen, Yawei Shi, Huijuan Shi, Zhongyu Yuan, Xiaoping Li, Juan Xu, Zhenhai Cai, Jianping Guo, N. Shao, Ying Lin   +19 more
semanticscholar   +1 more source